A5100695476- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Molecular Biology Techniques and Applications
- Vector-borne infectious diseases
- Cancer-related molecular mechanisms research
- Plant Pathogens and Fungal Diseases
- MicroRNA in disease regulation
- Microbial infections and disease research
- Gut microbiota and health
- Pharmaceutical and Antibiotic Environmental Impacts
- Physiological and biochemical adaptations
- Antibiotics Pharmacokinetics and Efficacy
- Probiotics and Fermented Foods
- Single-cell and spatial transcriptomics
- Virus-based gene therapy research
- Fungal and yeast genetics research
- Plant and Fungal Interactions Research
- Microbial Natural Products and Biosynthesis
- Antibiotic Resistance in Bacteria
- Antifungal resistance and susceptibility
- Turtle Biology and Conservation
- Genetic and phenotypic traits in livestock
- Escherichia coli research studies
- Animal health and immunology
- Clostridium difficile and Clostridium perfringens research
Chengdu Research Base of Giant Panda Breeding
2016-2025
State Forestry and Grassland Administration
2022-2025
Xiamen University
2025
First Affiliated Hospital of Dalian Medical University
2022
Anhui Science and Technology University
2022
Anhui University of Science and Technology
2022
Dalian Medical University
2022
Sichuan Agricultural University
2011-2017
Sichuan University
2016
The physiological role of miRNAs is widely understood to include fine-tuning the post-transcriptional regulation a wide array biological processes. Extensive studies have indicated that exosomal in bodily fluids various organisms can be transferred between living cells for delivery gene silencing signals. Here, we illustrated expression characteristics giant panda breast milk during distinct lactation periods and highlighted enrichment immune- development-related endogenous colostral mature...
Abstract Background In this study, we sequenced and phylogenetic analyses of the VP2 genes from twelve canine parvovirus (CPV) strains obtained eleven domestic dogs a giant panda ( Ailuropoda melanoleuca ) in China. A novel was detected Results Nucleotide analysis capsid protein gene classified CPV as new CPV-2a type. Substitution Gln for Arg at conserved 370 residue presents an unusual variation amino acid sequence is further evidence continuing evolution virus. Conclusions These findings...
A female giant panda presented with a large, hard mass on the right cheek, which was investigated at Dujiangyan Base of China Conservation and Research Center for Giant Panda computed tomography (CT) scans biopsy oral mass, as well venous blood sampling. Hematological tests revealed elevated levels tumor marker CA724, along infectious disease, anemia, hepatic damage, renal failure. Imaging studies identified soft tissue in cheek area. Macroscopic pathological changes, histopathological...
The performance of the donor–acceptor polymer PDPP-TEG-2Tz in organic electrochemical transistors was investigated using various anions.
The independent dietary shift from carnivore to herbivore with over 90% being bamboo in the giant and red pandas is of great interests biologists. Although previous studies have shown convergent evolution at both morphological molecular level, gut microbiota these remains largely unknown. goal this study was determine whether converged due same diet, or diverged. We characterized fecal two species by pyrosequencing 16S V1-V3 hypervariable regions using 454 GS FLX Titanium platform. also...
Reintroduction is a key approach in the conservation of endangered species. In recent decades, many reintroduction projects have been conducted for purposes, but rate success has low. Given important role gut microbiota health and diseases, we questioned whether would play crucial giant panda's wild-training process. The wild procedure when captive-born babies live with their mothers wilderness enclosure learn survival skills from mothers. During process, baby pandas undergo tests regular...
Sperm cryopreservation and artificial insemination are important methods for giant panda breeding preservation of extant genetic diversity. Lower conception rates limit the use with frozen-thawed sperm, due to lack understanding cryodamaging or cryoinjuring mechanisms in cryopreservation. Long non-coding RNAs (lncRNAs) involved regulating spermatogenesis. However, their roles during remain largely unexplored. Therefore, this study aimed identify differentially expressed lncRNAs mRNAs...
Although Escherichia coli typically colonizes the intestinal tract and vagina of giant pandas, it has caused enteric systemic disease in pandas greatly impacts health survival this endangered species. In order to understand distribution characteristics E. from 67 fecal 30 vaginal isolates 21 were characterized for O serogroups, phylogenetic groups, antimicrobial susceptibilities, pulsed-field gel electrophoresis (PFGE) profiles. addition, these tested presence extraintestinal pathogenic...
Post-thawed sperm quality parameters vary across different species after cryopreservation. To date, the molecular mechanism of cryoinjury, freeze-tolerance and other influential factors are largely unknown. In this study, significantly dysregulated microRNAs (miRNAs) mRNAs in boar giant panda with cryo-resistance capacity were evaluated. From result miRNA profile fresh frozen-thawed sperm, a total 899 mature, novel miRNAs identified, 284 found to be (195 up-regulated 89 down-regulated)....
Abstract Background Canine distemper virus (CDV) infects a variety of carnivores, including wild and domestic Canidae. In this study, we sequenced phylogenetic analyses the hemagglutinin (H) genes from eight canine isolates obtained seven raccoon dogs ( Nyctereutes procyonoides ) giant panda Ailuropoda melanoleuca in China. Results Phylogenetic analysis partial gene sequences showed close clustering for geographic lineages, clearly distinct vaccine strains other wild-type foreign CDV...
Vision plays a crucial role in the survival of animals, and visual system has particularly selectively evolved response to environment, ecological niche, species habitats vertebrate species. To date, horizontal streak retinal ganglion cell (RGC) distribution pattern is observed across mammal Here, we report that giant panda's vertically oriented streak, combined with current evidence animal's forward-placed eyes, ocular structure, neural topographic patterns, presents emergence well-adapted...
In the giant panda, adaptation to a high-fiber environment is first step for adequate functioning of intestinal bacteria, as high cellulose content gut due panda's vegetarian appetite results in harsh environment. As an excellent producer several enzymes and vitamins, Bacillus subtilis imparts various advantages animals. our previous study, we determined that strains B. isolated from pandas exhibited good decomposition ability, hypothesized this bacterial species can survive adapt well To...
The giant panda (Ailuropoda melanoleuca) is a vulnerable species and charismatic member of zoological collections worldwide. Despite its importance as representative for global wildlife conservation efforts, no studies to date have described normal cell morphology or cytoplasmic constituents by traditional techniques such cytochemical staining evaluation ultrastructural features. objective this study was accurately identify characterize the leukocytes platelets clinically healthy pandas...
Recently, an increasing number of microsatellites or simple sequence repeats (SSRs) have been found and characterized from transcriptomes. Such SSRs can be employed as putative functional markers to easily tag corresponding genes, which play important role in biomedical studies genetic analysis. However, the transcriptome-derived for giant panda (Ailuropoda melanoleuca) are not yet available. In this work, we identified 20 tetranucleotide microsatellite loci a transcript database generated...
Gene differential expression studies can serve to explore and understand the laws characteristics of animal life activities, difference in gene between different tissues has been well demonstrated studied. However, for world-famous rare protected species giant panda (Ailuropoda melanoleuca), only transcriptome blood spleen reported separately. Here, order differences panda, profiles heart, liver, spleen, lung, kidney from five captive pandas were constructed with Illumina HiSeq 2500...
Medullary thyroid carcinoma (MTC) is a malignant neuroendocrine tumor with high recurrence rate. Amyloid plaques formed from the misfolding of calcitonin are key characteristics MTC. Herein, we conducted first-in-human pilot clinical study by applying β-amyloid-specific radiotracer, [18F]AV-45, to positron emission tomography (PET)/computed (CT) imaging The presence amyloid in tissue sections five MTC patients was confirmed hematoxylin and eosin (H&E) Congo Red staining. [18F]AV-45...
Captive populations provide a precious genetic resource for endangered animals and source of individuals reintroduction to depleted habitats. Therefore, accuracy in determining paternity is vital importance managing captive selecting representative known characteristics release. In this study, we established fast effective method conduct testing giant pandas the Wolong population. This technique uses two highly polymorphic microsatellites initially, subsequent use five less markers then...
Ovarian cancer is diagnosed clinically by detecting ovarian cancer-related factors and markers. Here, we report a case of giant panda tumor metastasis with combination clinical histopathological diagnosis. Histopathological studies revealed severe lesions cells in the ovaries, lungs, spleen, kidneys perianal tissue. Immunohistochemistry staining showed that markers B7-H4, CA125, HE4 were highly expressed kidneys, ovaries Tumor marker tests detected significantly high levels AFP serum....
The blood-sucking tick Haemaphysalis hystricis is a common ectoparasite of the giant panda and represents significant threat to both wild captive populations. Herein, complete mitogenome H. was sequenced using Illumina sequencing technology. sequence 14,715 bp in size encoded 37 genes including 13 protein-coding genes, 22 transfer RNAs, two ribosomal RNAs. Phylogeny revealed that isolates hystricis, regardless host origins locations, grouped together had closer relationship with longicornis...