A5100350982- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Drug Transport and Resistance Mechanisms
- Advancements in Transdermal Drug Delivery
- Pharmacological Effects of Natural Compounds
- Caveolin-1 and cellular processes
- biodegradable polymer synthesis and properties
- Anodic Oxide Films and Nanostructures
- Advanced ceramic materials synthesis
- RNA Interference and Gene Delivery
- Surfactants and Colloidal Systems
- Peptidase Inhibition and Analysis
- Dendrimers and Hyperbranched Polymers
- Nanoplatforms for cancer theranostics
- Advanced Computational Techniques and Applications
- Corneal surgery and disorders
- Drug Solubulity and Delivery Systems
- Drug-Induced Hepatotoxicity and Protection
- Service-Oriented Architecture and Web Services
- dental development and anomalies
- Protease and Inhibitor Mechanisms
- Ocular Surface and Contact Lens
- Natural product bioactivities and synthesis
- Nanomaterials for catalytic reactions
Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine
2025
Peking University
2015-2024
Wuhan University of Technology
2010-2024
Chinese Academy of Sciences
2013-2024
Jilin University
2024
Peking University Third Hospital
2010-2024
Hezhou University
2022-2024
Anyang Normal University
2024
Shanghai Institute of Ceramics
2020-2024
University of Chinese Academy of Sciences
2020-2024
Abstract Background Chemicals of herbal products may cause unexpected toxicity or adverse effect by the potential for alteration activity CYP450 when co-administered with other drugs. Eleutherococcus senticosus (ES), has been widely used as a traditional medicine and popular dietary supplements, often many The main bioactive constituents ES were considered to be eleutherosides including eleutheroside B (EB) E (EE). This study was investigate effects EB EE on CYP2C9, CYP2D6, CYP2E1 CYP3A4 in...
Melanosomes in black and red human hair are isolated characterized by various chemical physical techniques. Different yields of 4-amino-hydroxyphenolanaline HI hydrolysis (a marker for pheomelanin) pyrrole-2,3,5-tricarboxylic acid KMnO4/H oxidation eumelanin) indicate that the melanosomes eumelanosomes, whereas those mainly pheomelanosomes. Atomic force microscopy reveals eumelanosomes pheomelanosomes have ellipsoidal spherical shapes, respectively. Eumelanosomes maintain structural...
The purpose of this study was to evaluate the feasibility in situ thermosensitive hydrogel based on chitosan combination with disodium α-d-Glucose 1-phosphate (DGP) for ocular drug delivery system. Aqueous solution chitosan/DGP underwent sol–gel transition as temperature increased which flowing sol at room and then turned into non-flowing physiological temperature. properties gels were characterized regarding gelation time, temperature, morphology. sol-to-gel phase behaviors affected by...
Radiation therapy is an effective method to kill cancer cells and shrink tumors using high-energy X-ray or γ-ray. pneumonitis (RP) one of the most serious complications radiation for thoracic cancers, commonly leading respiratory distress poor prognosis. Here, we prepared curcumin-loaded mesoporous polydopamine nanoparticles (CMPN) prevention treatment RP by pulmonary delivery. Mesoporous (MPDA) were successfully synthesized with emulsion-induced interface polymerization curcumin was loaded...
A series of monomethoxy poly(ethylene glycol)-poly(lactide) (mPEG-PLA) diblock copolymers were synthesized, and mPEG-PLA micelle was fabricated used as a nanocarrier for solubilization delivery promising anticancer drug ethaselen. Ethaselen efficiently encapsulated into the micelles by dialysis method, solubility ethaselen in water remarkably increased up to 82 μg/mL before freeze-drying. The mean diameter ethaselen-loaded ranged from 51 98 nm with narrow size distribution depended on length...
In the absence of solvent, highly selective hydrogenation o-chloronitrobenzene and m-chloronitrobenzene, with selectivity to corresponding chloroanilines ≥99.4% complete conversion substrates, was realized over a robust Pt/Fe3O4 catalyst which prepared by adsorbing Pt nanoclusters on Fe3O4 support.
Objective Energetic adaptations induced by bariatric surgery have not been studied in adolescents or for extended periods postsurgery. Energetic, metabolic, and neuroendocrine responses to Roux‐en‐Y gastric bypass (RYGB) were investigated extremely obese adolescents. Methods At baseline at 1.5, 6, 12 months post‐baseline, 24‐h room calorimetry, body composition, fasting blood biochemistries measured 11 relative five matched controls. Results In the RYGB group, mean weight loss was 44 ± 19 kg...
Abstract Polymeric micelles prepared from a series of poly(ethylene glycol)–poly(lactide) (PEG–PLA) diblock copolymers with various PLA chain lengths were designed as drug carriers for water insoluble amphotericin B (AmB). Physicochemical properties AmB‐loaded evaluated. Micelles freeze‐dried to obtain long‐time stable formulations. The redispersibility the samples was poor when weight ratio block bigger than PEG copolymer. Various types lyoprotectants including saccharides and PEGs...
Abstract Polyion complex micelles (PIC micelles) based on methoxy poly(ethylene glycol)‐ grafted ‐chitosan (mPEG‐ g ‐Chitosan) and lactose‐conjugated PEG‐ (Lac‐PEG‐ were designed as carriers for anionic drugs. Diammonium glycyrrhizinate (DG)‐loaded conventional PIC (mPIC lactose‐modified (Lac‐PIC prepared successfully with encapsulation efficiency of 97.4% 96.7%, respectively. These uniform spherical particles a mean size 21.6 26.4 nm by transmission electron microscopy, No significant...
The purpose of this work was to explore the feasibility ethosomes for improving antiarthritic efficacy tetrandrine by topical application. It found that a weak base (pK(a) = 7.06) with pH-dependent partition coefficient. spherical-shaped were prepared pH gradient loading method. Ex vivo permeation and deposition behavior demonstrated drug flux across rat skin in 2.1- 1.7-fold higher than liposomes, respectively. Confocal laser scanning microscopy confirmed could enhance delivery terms depth...
Dual endosomal pH-sensitive micelles were designed and fabricated to deliver doxorubicin (DOX) for treating breast cancer based on a poly(2-ethyl-2-oxazoline) (PEOz)–DOX (PEOz–hyd–DOX) conjugate. PEOz–hyd–DOX was successfully synthesized by connecting DOX PEOz via an acid cleavable hydrazone linker self-assembled into nanosized micelles, which further physically encapsulated DOX. The conjugate DOX-loaded displayed faster release of at pH 5.0 than 7.4. This pH-dependent behavior might assist...