A5100379134- Plant biochemistry and biosynthesis
- Sesquiterpenes and Asteraceae Studies
- Molecular Sensors and Ion Detection
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Advanced biosensing and bioanalysis techniques
- Insect Resistance and Genetics
- Electrochemical Analysis and Applications
- DNA Repair Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Insect Pest Control Strategies
- Luminescence and Fluorescent Materials
- Ginseng Biological Effects and Applications
- Carbohydrate Chemistry and Synthesis
- Carcinogens and Genotoxicity Assessment
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- Inflammasome and immune disorders
- Genetics and Neurodevelopmental Disorders
- Parvovirus B19 Infection Studies
- RNA modifications and cancer
- Neurological Disease Mechanisms and Treatments
- Analytical Chemistry and Sensors
- Cancer Research and Treatments
Xinjiang Agricultural University
2024-2025
Zhengzhou People's Hospital
2024-2025
Tianjin University of Traditional Chinese Medicine
2025
University of Tübingen
2017-2024
First Hospital of Jilin University
2024
Henan University of Technology
2022-2024
Jilin University
2024
Shaanxi University of Chinese Medicine
2022-2024
Affiliated Hospital of Hangzhou Normal University
2024
Nagoya University
2023
A water-soluble fluorescent sensor, 1, based on the quinoline platform, demonstrates femtomolar sensitivity for zinc ion with a 14-fold enhanced quantum yield upon chelation to and also exhibits high selectivity over other physiological relevant divalent metals in presence of EDTA. X-ray crystal structure complex reveals that an acetic carboxylic group participates coordination, which significantly enhances affinity 1 ion.
Although cadmium has been recognized as a highly toxic heavy metal and poses many detrimental effects on human health, the Cd2+-uptake nosogenesis mechanisms are still insufficiently understood, mainly because of lack facile analytical methods for monitoring changes in environmental intracellular Cd2+ concentrations with high spatial temporal reliability. To this end, we present design, synthesis, photophysical properties sensor, DQCd1 based fluorophore...
In aqueous solution, sensor DQAg can selectively detect Ag+ based on inhibition of the resonance, demonstrating a large hypsochromic shift 84 nm and remarkable changes in ratio (F481 nm/F565 nm) emission intensity (R/R0 up to 26-fold). Furthermore, resultant Ag–DQAg also displays ratiometric highly selective response iodide anion over other anions due liberation from complex by precipitating AgI.
In recent decades, the antihyperglycemic biguanide metformin has been used extensively in treatment of type 2 diabetes, despite continuing uncertainty over its direct target. this article, using two independent approaches, we demonstrate that cellular actions are disrupted by interference with metal-binding properties, which have known for a century but little studied biologists. We copper sequestration opposes not only on AMP-activated protein kinase (AMPK)-dependent signaling, also S6...
Zinc-finger E-box binding homeobox 1 (Zeb1) is a key regulator of epithelial-mesenchymal transition and cancer metastasis. Mutation ZEB1 associated with human diseases defective brain development. Here we show that downregulation Zeb1 expression in embryonic cortical neural progenitor cells (NPCs) necessary for proper neuronal differentiation migration. Overexpression during differentiation, when its normally declines, blocks NPC lineage progression disrupts multipolar-to-bipolar...
Arsenic pollution in groundwater remains a serious public health concern around the world. Recent years, arsenic-related neurological and psychiatric disorders have been reported increasingly. However, exact mechanisms of it elusive. In this study, arsenic exposure through drinking water resulted depression-/anxiety-like behaviors mice accompanied by oxidative stress NOD-like receptor thermal protein domain associated 3 (NLRP3) inflammasome activation prefrontal cortex (PFC) hippocampus, two...
Interferon regulatory factor 2 (IRF2) participates in the differentiation of immune T cells. Bone marrow mesenchymal stem cell (BM-MSC)-derived exosomes can secret mRNA, miRNAs, and proteins to regulate tumor microenvironment. The present study focused on miRNA/IRF2 axis regulating Th1/Th2 ratio apoptosis acute myeloid leukemia (AML). flow cytometry analysis was performed examine AML vivo vitro. contents γ (IFN-γ) Interleukin-4 (IL-4) were measured using enzyme-linked immunosorbent assay....
Abstract We to measure the serum levels of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in patients diagnosed with connective tissue disease (CTD)-associated pulmonary arterial hypertension (PAH) (CTD-PAH) analyze their clinical implications. Thirty who were CTD-PAH via right heart catheterization (RHC) enrolled observation group. Additionally, twenty CTD without PAH (CTD-non-PAH) CTD-non-PAH group, healthy participants control Additional data on...
Abstract In the past 20 years, peptide‐based antibiotics, such as vancomycin, teicoplanin, and daptomycin, have often been considered second‐line antibiotics. However, in recent an increasing number of reports on vancomycin resistance pathogens appeared, which forces researchers to find novel lead structures for potent new Herein, we report total synthesis a defined endo‐type B PPAP library their antibiotic activity against multiresistant S. aureus various vancomycin‐resistant Enterococci ....
Matricaria recutita (German chamomile) and Chamaemelum nobile (Roman belong to the botanical family Asteraceae. These two herbs are not only morphologically distinguishable, but their secondary metabolites - especially essential oils present in flowers also different, terpenoids. The aim of this project was preliminarily identify regulatory mechanisms terpenoid biosynthetic pathways that differ between German Roman chamomile by performing comparative transcriptomic metabolomic analyses.We...
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and a major cause death. However, molecular mechanisms underlying CRC initiation, growth metastasis are poorly understood. Dragon (RGMb), member repulsive guidance molecule (RGM) family, has been recently identified as co-receptor for bone morphogenetic protein (BMP) signaling, but role in development undefined. Here, we show that expression was increased colon tissues compared to control CAC mouse model human patients....
The transmembrane protein, ADAM10 (a disintegrin and metalloprotease 10), has key physiologic functions-for example, during embryonic development in the brain. During transit through secretory pathway, immature (proADAM10) is converted into its proteolytically active, mature form (mADAM10). Increasing or decreasing abundance and/or activity of mADAM10 considered to be a therapeutic approach for treatment such diseases as Alzheimer's disease cancer. Yet biochemical detection characterization...
Diamondback moth, Plutella xylostella (L.; Lepidoptera: Plutellidae), is an important pest of crucifers worldwide. The extensive use diamide insecticides has led to P. resistance and this presents a serious threat vegetable production. We selected chlorantraniliprole (Rf) flubendiamide (Rh) strains with ratios 684.54-fold 677.25-fold, respectively. Rf Rh underwent 46 36 generations lab-selection for resistance, Low cross cyantraniliprole was found. Cross chlorfenapyr, tebufenozid, indoxacarb...
Recently, a series of endo-type B polycyclic polyprenylated acylphloroglucinols (PPAP) derivatives with high antimicrobial activities were chemically synthesized. One the derivatives, PPAP 23, which showed activity and low cytotoxicity, was chosen for further investigation its bactericidal profiles mode action. 23 better efficacy in killing methicillin resistant S. aureus (MRSA) decreasing metabolic 5-day-old biofilm cells than vancomycin. Moreover, did not appear to develop resistance...