A5081008585- Peptidase Inhibition and Analysis
- Radiopharmaceutical Chemistry and Applications
- Effects of Radiation Exposure
- Advanced NMR Techniques and Applications
- Brain Metastases and Treatment
- Hernia repair and management
- Musculoskeletal Disorders and Rehabilitation
- Sulfur Compounds in Biology
- Porphyrin Metabolism and Disorders
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Prostate Cancer Treatment and Research
- Infant Nutrition and Health
- Functional Brain Connectivity Studies
- IgG4-Related and Inflammatory Diseases
- Lung Cancer Research Studies
- Alcohol Consumption and Health Effects
- Intestinal and Peritoneal Adhesions
- Advanced MRI Techniques and Applications
- Hearing Loss and Rehabilitation
- Intraperitoneal and Appendiceal Malignancies
- Soft tissue tumor case studies
- Immunotherapy and Immune Responses
- Kidney Stones and Urolithiasis Treatments
- Ultrasound and Hyperthermia Applications
University of South China
2017-2024
Southern Medical University
2023-2024
Nanfang Hospital
2023-2024
Hunan Children's Hospital
2023
XinHua Hospital
2019
Shanghai Mental Health Center
2017
Radiation therapy is an effective method to kill cancer cells and shrink tumors using high-energy X-ray or γ-ray. pneumonitis (RP) one of the most serious complications radiation for thoracic cancers, commonly leading respiratory distress poor prognosis. Here, we prepared curcumin-loaded mesoporous polydopamine nanoparticles (CMPN) prevention treatment RP by pulmonary delivery. Mesoporous (MPDA) were successfully synthesized with emulsion-induced interface polymerization curcumin was loaded...
Cancer remains one of the leading causes death globally and metastasis always leads to treatment failure. Here, we develop a versatile hydrogel loading photothermal agents, chemotherapeutics, immune-adjuvants eradicate orthotopic tumors inhibit by combinational therapy. Hydrogel networks were synthesized via thiol-Michael addition polydopamine (PDA) with thiolated hyaluronic acid. PDA acted as cross-linking agent endowed excellent property. Meanwhile, chemotherapeutic agent, doxorubicin...
Smoke bombs are often used in military/fire training, which can produce a large amount of zinc chloride (ZnCl2) smoke. Inhalation ZnCl2 smoke usually causes acute lung injury (ALI) that would likely develop to respiratory distress syndrome (ARDS). However, there is no effective prevention or treatment strategy for the smoke-induced ALI. Resveratrol (RES) natural polyphenol with good anti-inflammatory and anti-apoptotic activities, but its low solubility, stability, bioavailability restrict...
To explore the therapeutic effect of curcumin (Cur) and soybean oligosaccharides (SBOS) on ulcerative colitis (UC) through testing intestinal flora (UC). 80 male SD rats were selected divided into four groups with 20 in each group: normal group, sulfasalazine (SASP) model group plus soy oligosaccharide. All animals treated for 4 weeks. In fifth week decapitated. Macroscopic damage scores colonic mucosa calculated. A 4mL blood sample was taken to detect contents serum tumor necrosis factor...
Primary hyperoxalurias (PHs) are inherited metabolic disorders marked by enzymatic cascade disruption, leading to excessive oxalate production that is subsequently excreted in the urine. Calcium deposition renal tubules and interstitium triggers injury, precipitating systemic build-up subsequent secondary organ impairment. Recent explorations of novel therapeutic strategies have challenged necessitated reassessment established management frameworks. The execution diverse clinical trials...
Acute liver failure (ALF) is a devastating clinical syndrome with high mortality rate if not treated promptly. Previous studies have demonstrated the beneficial effects of hydrogen sulfide (H2S) on brain and liver. The present study aimed to investigate potential protective H2S in ALF. A mouse model ALF was established following treatment thioacetamide (TAA). Mice TAA‑induced were intraperitoneally injected 30 or 100 µmol/kg/day sodium hydrosulfide (NaHS; donor drug) for two weeks. According...
Abstract Background Inflammatory myofibroblastic tumor (IMT) is a unique, rarely metastatic composed of myofibroblasts and fibrous spindle cells with inflammatory cell infiltration that can affect any organ in the human body. By reviewing relevant literature on PubMed, we found this first case report IMT both gastric cardiac involvement. Case presentation A 57-year-old male patient was admitted to hospital complaints malaise, poor appetite, epigastric pain black stools. We mass patient’s...
Background: Hepatic fibrosis is a progressive disease, which reversible in the early stages. The current monitoring methods have notable limitations that pose challenge to detection. In this study, we evaluated utility of [ 18 F]AlF-ND-bisFAPI positron emission tomography imaging fibroblast activation protein (FAP) monitor progression liver fibrosis. Methods: Two mouse models were established by bile duct ligation and carbon tetrachloride administration, respectively. Positron was performed...
To alleviate radiation-induced lung injury and prevent the related pneumonitis pulmonary fibrosis by inhaled amifostine (AMI). 15 Gy 60Co γ-ray irradiation was performed on thoracic area of rats once to establish radiation model. AMI intraperitoneally (i.p.) injected or intratracheally (i.t.) administered 30 min pre-irradiation. The protective effects two administration manners were compared in aspects hematopoietic system, edema, histopathological examination, mechanisms explored....
Recently, we developed a bivalent prostate-specific membrane antigen (PSMA) radioligand ([
Objective: To explore the long-term effect of combined surgery for treatment congenital tibial pseudarthrosis in children. Methods: The clinical data 44 children with who underwent (tibial tissue resection, intramedullary rod fixation, Ilizarov external fixator wrapped autologous iliac bone graft) from August 2007 to October 2011 at Department Pediatric Orthopedics, Hunan Children's Hospital were collected retrospectively. There 33 males and 11 females. age time was (3.7±2.2)years (range:0.6...
Objective Taking the hippocampus as seed, to investigate characteristics of white matter in patients with major depressive disorder (MDD) and bipolar depression (BD). Methods 33 MDD BD according Fourth Edition Diagnostic Statistical Manual Mental Disorders diagnostic criteria, accompanying 33 healthy controls (HC) matching age, sex education years were analyzed. All subjects underwent MRI scanning, acquiring diffusion tensor imaging (DTI) data. Taking adopt fiber tracing by DSIstudio...
Objective To explore the characteristics of spontaneous neural activity resting-state brain function in patients with bipolar depressionby using fractional amplitude low frequency fluctuation (fALFF). Methods Resting-state functional magnetic resonance data twenty-six depression and healthy controls was finally adopted by processing. After preprocessing imaging data, (fALFF) values used to estimate activities different regions. Finally, a two sample t-test performed on mean fALFF...
Objective:The aim of this study is to investigate the use CT, magnetic resonance imaging （MRI）, functional （fMRI） and electrical evoked auditory brainstem response in children with cochlear nerve deficiency （CND） before implantation （CI） （electrically brain stem response, EABR） evaluated pathway, cortex function, function. Method:Of 6 bilateral profound sensorineural hearing loss, internal meatus stenosis was diagnosed by CT as 4 cases unilateral 1 case. In 3 cases, oblique sagittal MRI...