A5100732454- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Cardiac Structural Anomalies and Repair
- Advanced Radiotherapy Techniques
- MRI in cancer diagnosis
- Protease and Inhibitor Mechanisms
- Viral-associated cancers and disorders
- Sarcoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Advanced X-ray and CT Imaging
Kunming Medical University
2019-2024
Southern Medical University
2015-2024
Nanfang Hospital
2015-2024
Guangzhou Medical University
2017-2024
Shandong Tumor Hospital
2013-2024
Shandong First Medical University
2013-2024
Wuhan University of Technology
2024
Hebei Medical University
2023
Xingtai People's Hospital
2023
Jiaxing University
2023
Background Gallium 68 (68Ga)–labeled fibroblast-activation protein inhibitor (FAPI) has recently been introduced as a promising tumor imaging agent. Purpose To compare 68Ga-FAPI PET/CT with fluorine 18 (18F)–labeled fluorodeoxyglucose (FDG) in evaluating lung cancer. Materials and Methods In this prospective study conducted from September 2020 to February 2021, images participants cancer who underwent both 18F-FDG examinations were analyzed. The tracer uptakes, quantified by maximum...
Induction of cancer cell ferroptosis has been proposed as a potential treatment in several types. Tumor-associated macrophages (TAMs) play key role promoting tumor malignant progression and therapy resistance. However, the roles mechanisms TAMs regulating is still unexplored remains enigmatic. This study shows inducers shown therapeutic outcomes cervical vitro vivo. have found to suppress cells ferroptosis. Mechanistically, macrophage-derived miRNA-660-5p packaged into exosomes are...
Blood vessels in the tumor periphery have high pericyte coverage and are resistant to vascular disrupting agents (VDAs). VDA treatment resistance leads a viable peripheral rim that contributes failure disease recurrence. Here, we provide evidence support hypothesis shifting target of VDAs from vessel endothelial cells pericytes disrupts rim, circumventing resistance. Through chemical engineering, developed Z-GP-DAVLBH (from tubulin-binding desacetylvinblastine monohydrazide [DAVLBH]) as...
Staphylococcus aureus is the most common etiological pathogen of bovine mastitis. The resistant strains make disease difficult to cure. aim this study was characterize genetic nature antimicrobial resistance in S. cultured from mastitis Northwest China 2014. A total 44 were isolated for and resistance-related genes. Antimicrobial determined by disc diffusion corresponding genes detected PCR. Phenotype indicated that isolates penicillin (84.09%), erythromycin (20.45%), tetracycline (15.91%),...
Due to tumor heterogeneity and complex tumor-stromal interactions in multicellular systems, the efficiency of monospecific tracers for diagnosis therapy is currently limited. In light evidence prostate-specific membrane antigen (PSMA) overexpression cells fibroblast activation protein (FAP) upregulation stroma, heterodimer dual targeting PSMA FAP may have potential improve diagnosis. Herein, we described radiosynthesis, vitro characterization, micro-PET/CT imaging two novel 18F-labeled...
F-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET)/computed (CT) alone has limited sensitivity for the diagnosis of hepatocellular carcinoma (HCC). We hoped to improve diagnostic by combining FDG and C-choline PET/CT.A total 76 consecutive patients with HCC were prospectively enrolled. Whole-body PET/CT scan was performed all patients. In those negative scans, a regional also performed.Positive scans noted in 61.1% (48/76) HCC. Increased uptake correlated decreased tumor...
A scalable electrochemical difunctionalization of gem-difluoroalkenes to structurally versatile difluoro motifs was achieved. This methodology features reagent-free conditions, good functional group tolerance, and a relatively broad substrate scope. Meanwhile, the electrolysis protocol is easy handle, products show regio- chemoselectivity. The reaction mechanism also preliminarily studied.
Concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, optimal radiotherapy regimen, particularly in terms of total dose and planned range irradiation field, remains unclear. This phase III clinical trial aimed to compare survival benefits between different radiation doses target fields.
Extranodal natural killer (NK)/T-cell lymphoma is a rare neoplasm and limited data has reported regarding the utilization of fluorine-18, fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in this disease. The aim study was to assess role F-FDG PET/CT staging NK/T-cell lymphomas.Thirteen newly diagnosed two recurrent patients with who received were studied. lesion intense uptake suggested as positive measured using maximal standardized values. results compared...
The knowledge of mosquito species diversity and the level anthropophily exhibited by each in a region are great importance to integrated vector control. Culicine primary vectors Japanese encephalitis (JE) virus filariasis China. Anopheles sinensis plays major role maintenance Plasmodium vivax malaria transmission goal this study was compare abundance host-seeking behavior culicine An. Yongcheng city, representative P. malaria. Specifically, we wished determine relative attractiveness...
Apelin plays an important role in many types of tumors. We aimed to identify the effects miR-195 on inhibiting apelin and clarify regulating mechanism miR-195-apelin lung adenocarcinoma cells.We detected expression levels tissues cancer cell lines using Western blotting quantitative reverse transcription PCR assay, respectively. Luciferase reporter assay was used confirm target gene miR-195. The proliferation cycle cells were assessed by methyl thiazolyl tetrazolium colony formation assays,...
A direct electrolysis protocol for difluorination and azo-fluorination of gem -difluorostyrenes was achieved involving Et 3 N·3HF as fluorine source. The electrochemical reduction the benzyl C–F bond also achieved.
Based on the discordance of human epidermal growth factor receptor-2 (HER2) expression between primary and metastatic/recurrent breast cancer, HER2 molecular imaging, which had potential to systemically assess dynamically monitor expression, might improve selection patients for anti-HER2 therapy. In this study, designed ankyrin repeat protein (DARPin) G3, a novel binding with picomolar affinity HER2, was used multifunctional superparamagnetic nanoparticles modified...
To investigate the relationship between glucose metabolism and glypican-3 (GPC3) expression in hepatocellular carcinoma (HCC).Immunohistochemical staining of pathological samples for GPC3 transporter 1 (GLUT1), whole-body 18F-FDG PET/CT measuring tumour uptake were performed 55 newly diagnosed HCC patients. The maximum standard value (SUVmax) tumour-to-non-tumourous liver (T/NT) ratio used to quantify uptake. In vitro18F-FDG assay GPC3-expressing HepG2 non-GPC3-expressing RH7777 cells was...
Background This study aimed to explore the potentially predictive role and dynamic changes of immune checkpoints on T cell subsets in patients with breast cancer receiving neoadjuvant chemotherapies. Methods Fluorescent multiplex immunohistochemistry (mIHC) was used stain CD4, CD8, PD1, TIM3, cytokeratins simultaneously paired samples before after therapies (NAT) a prospective cohort ( n = 50). Singleplex IHC conducted for CD3 100 cases inclusion extra retrospective 50 cases. Cell levels...