A5002907320- Galectins and Cancer Biology
- Macrophage Migration Inhibitory Factor
- Lung Cancer Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Advanced Radiotherapy Techniques
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Radiation Therapy and Dosimetry
- Vector-borne infectious diseases
- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Endoplasmic Reticulum Stress and Disease
- Effects of Radiation Exposure
- Cancer-related Molecular Pathways
- Medical Imaging Techniques and Applications
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- Vascular Tumors and Angiosarcomas
- interferon and immune responses
- Radiation Detection and Scintillator Technologies
Henan Cancer Hospital
2018-2025
Zhengzhou University
2018-2025
Naval Medical Research Command
2010-2024
Central Hospital of Zibo
2022-2024
Fudan University Shanghai Cancer Center
2022
Duke University
2011
National Institutes of Health
1999
Non-inflamed tumors, including immune-excluded and immune-desert are commonly resistant to anti-PD-1/PD-L1 (α-PD-1/PD-L1) therapy. Our previous study reported the potent antitumor activity of anti-TGF-β/PD-L1 bispecific antibody YM101 in tumors. However, had limited models. MSA-2 is a novel oral stimulator interferon genes (STING) agonist, which activates innate immune system may synergize with overcoming immunotherapy resistance.The dose-dependent effect on STING signaling was determined by...
Overcoming resistance to radiation is a major challenge in cancer treatment. Stearoyl-coa desaturase (SCD1) the enzyme responsible for oleic acid (OA) and palmitoleic (POA) formation. Here, we provided evidence that targeting SCD1 was capable of inducing ferroptosis immunogenic cell death (ICD), thereby improving sensitivity esophageal squamous carcinoma (ESCC). ESCC lines with high expression were treated MF-438 (SCD1 inhibitor) determine viability. Colony formation assay performed evaluate...
A novel rickettsial agent, 'Candidatus Rickettsia asembonensis' strain NMRCiiT, was isolated from cat fleas, Ctenocephalides felis, Kenya. Genotypic characterization of the new isolate based on sequence analysis five genes, rrs, gltA, ompA, ompB and sca4, indicated that this clustered with felis URRWXCal2. The degree nucleotide similarity demonstrated NMRCiiT belongs within genus fulfils criteria for classification as a representative species. name asembonensis sp. nov. is proposed, (=DSM...
Abstract While new sequencing technologies have ushered in an era where microbial genomes can be easily sequenced, the goal of routinely producing high-quality draft and finished a cost-effective fashion has still remained elusive. Due to shorter read lengths limitations library construction protocols, shotgun assembly based on these often results fragmented assemblies. Correspondingly, while assemblies obtained days, finishing take many months hence time effort only justified for...
Backgrounds/Aims: MicroRNAs (miRs) often contribute to the progression of non-small cell lung cancer (NSCLC) via regulation mRNAs that are involved in homeostasis. We conducted a study aimed at exploring roles miR-183 proliferation, epithelial-mesenchymal transition (EMT), invasion and migration human NSCLC cells targeting MTA1. Methods: adjacent normal tissues were collected from 194 patients with NSCLC. Positive expression MTA1 protein was detected by immunohistochemistry. The highest...
Concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, optimal radiotherapy regimen, particularly in terms of total dose and planned range irradiation field, remains unclear. This phase III clinical trial aimed to compare survival benefits between different radiation doses target fields.
Abstract Ultra‐high dose rate FLASH Radiotherapy (FLASH‐RT) has attracted wide attention because the well‐known effect and extremely short irradiation time. During FLASH‐RT, high radiation doses (usually thousands of times compared with conventional radiotherapy (CONV‐RT)) are delivered to tumor area. This novel technique shows a reduction normal tissue injury (20‐40%) in comparison CONV‐RT. Meanwhile, FLASH‐RT maintaining comparable killing as With progress basic research on reducing...
Abstract Objectives A novel risk stratification model based on Lung-RADS ® v2022 and CT features was constructed validated for predicting invasive pure ground-glass nodules (pGGNs) in China. Methods Five hundred twenty-six patients with 572 pulmonary GGNs were prospectively enrolled divided into training ( n = 169) validation 403) sets. Utilising the framework types of GGN-vessel relationships (GVR), a complementary established, pGGNs reclassified from categories 2, 3 4x 3, 4a, 4b,...
Osteosarcoma, ranking as the second primary cause of cancer-related death, is most common type bone cancer. Doxorubicin (DOX) used a first-line treatment for osteosarcoma; however, tumour recurrence rate remains high. Recent studies have suggested that DOX-induced migration and stemness in osteosarcoma cells might be reason drug resistance. However, underlying mechanisms remain unclear. Therefore, it urgent to explore novel effective treatments overcome resistance osteosarcoma.Osteosarcoma...
Orientia tsutsugamushi, an obligate intracellular bacterium that is auxotrophic for the aromatic amino acids and histidine, causes scrub typhus, a potentially deadly infection threatens 1 billion people. O. tsutsugamushi growth minimal during first 24 to 48 h of but its becomes logarithmic thereafter. How pathogen modulates cellular functions support poorly understood. The unfolded protein response (UPR) cytoprotective pathway relieves endoplasmic reticulum (ER) stress by promoting...
To investigate the effect of mannose on radio-sensitivity human esophageal squamous cell carcinoma (ESCC) line and its possible mechanism.The expression phosphate isomerase (MPI) in cancer lines were detected by Western blot. The inhibitory observed MTT assay. Plate clone formation assay was performed to efficacy cells. apoptosis rates tumor cells treated with and/or radiation therapy calculated flow cytometry. Furthermore, we analyzed intracellular metabolites using liquid chromatography...
Purpose: This study investigates the impact of lung function on radiation pneumonitis prediction using a dual-omics analysis method. Methods: We retrospectively collected data 126 stage III cancer patients treated with chemo-radiotherapy intensity-modulated radiotherapy, including pre-treatment planning CT images, radiotherapy dose distribution, and contours organs structures. Lung perfusion functional images were generated previously developed deep learning The whole (WL) volume was divided...
Resistance to paclitaxel poses a major obstacle in esophageal squamous cell carcinoma (ESCC) treatment. A better understanding of the mechanisms underlying resistance could help identify prognostic biomarkers and improved therapeutic strategies. In this study, we established patient-derived xenograft model acquired used RNA sequencing galectin-1, encoded by LGALS1, as key mediator resistance. Integrative analysis clinical data physiological studies indicated that serum galectin-1 levels were...
Immune escape is a frequent occurrence, which limits the duration of antitumor immune responses to radiotherapy. Here, we aimed ascertain roles and underlying mechanisms programmed death ligand 1 (PD-L1) in tolerance breast cancer (BC) We first quantified microRNA-21 (miR-21) PD-L1 expression BC tissues cells, followed by identification interactions between miR-21, PD-L1, cell protein 4 (PDCD4). miR-21 knock-in mice were used construct tumor-bearing models, then treated with anti-PD-L1...
Abstract Recently, apatinib has been shown to be effective in treating sarcoma. This study aimed assess the safety and efficacy of treatment patients with osteosarcoma after failed standard multimodal therapy compare therapeutic effects on between high-dose group low-dose group. A total 27 who received January 2016 August 2017 were retrospectively reviewed. Among patients, objective response rate (ORR) disease control (DCR) 25.93% 66.67%, respectively. The median progression-free survival...
Immunogenic cell death (ICD) is essential for the activation of immune system against cancer. We aimed to investigate efficacy endoplasmic reticulum (ER)-associated protein degradation (ERAD) inhibitors (EerI and NMS-873) in enhancing radiation-induced ICD esophageal cancer (EC). EC cells were administered with ERAD inhibitors, radiation therapy (RT), combination treatment. hallmarks including calreticulin (CALR), adenosine triphosphate (ATP), high mobility group B1 (HMGB1) detected. The...
Deep learning model has shown the feasibility of providing spatial lung perfusion information based on CT images. However, performance this method cancer patients is yet to be investigated. This study aims develop a transfer framework evaluate deep CT-to-perfusion mapping specifically patients.SPECT/CT scans 33 and 137 non-cancer were retrospectively collected from two hospitals. To adapt patients, was developed utilize features learned patients. These images processed extract...
ABSTRACT Rickettsia prowazekii is a notable intracellular pathogen, the agent of epidemic typhus, and potential biothreat agent. We present here whole-genome sequence data for four strains R. , including one from flying squirrel.
Anlotinib is a novel tyrosine kinase inhibitor with promising anti-tumor activity in patients advanced soft tissue sarcomas (STS) China. Liposomal doxorubicin monotherapy showed an encouraging effect on this disease. The aim of study was to evaluate the efficacy and safety anlotinib combined liposomal followed by maintenance metastatic STS.This multicenter, retrospective, observational study. We reviewed 27 STS from July 2018 December 2019, who were treated absence tumor progression or...