A5101969858- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Head and Neck Cancer Studies
- PI3K/AKT/mTOR signaling in cancer
- Cancer Treatment and Pharmacology
- Cancer-related gene regulation
- CRISPR and Genetic Engineering
- Angiogenesis and VEGF in Cancer
- Esophageal Cancer Research and Treatment
- RNA Research and Splicing
- Circular RNAs in diseases
- EEG and Brain-Computer Interfaces
- Sleep and Work-Related Fatigue
- Single-cell and spatial transcriptomics
- Cancer Mechanisms and Therapy
- Salivary Gland Tumors Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
Guangzhou Medical University
2011-2025
Children's Hospital of Chongqing Medical University
2022-2023
Chongqing Medical University
2022-2023
Guangdong Medical College
2023
Fuyang Second People's Hospital
2023
Southern Medical University
2019-2022
Qingdao University
2022
Affiliated Hospital of Qingdao University
2022
China International Science and Technology Cooperation
2022
Kaiping Central Hospital
2000-2020
Esophageal squamous cell carcinomas (ESCC) have become a severe threat to health and the current treatments for ESCC are frequently not effective. Recent epidemiological studies suggest that anti-hyperglycemic agent metformin may reduce risk of developing cancer, including ESCC, among diabetic patients. However, antitumor effects on mechanisms underlying its cycle regulation remain elusive. The findings reported herein show anti-proliferative action lines is partially mediated by AMPK....
AMP-activated protein kinase (AMPK) is a central metabolic sensor and plays an important role in regulating glucose, lipid cholesterol metabolism. Therefore, AMPK key therapeutic target diabetes. Recent pilot studies have suggested that diabetes drugs may reduce the risk of cancer by affecting pathway. However, association between proliferation hepatocellular carcinoma (HCC) unknown. In this study, we investigated relationship activity HCC cell lines, nude mice human clinic samples. We first...
The spatial proximity of CD8+ T cells to tumor critically influences the efficacy neoadjuvant therapy (NAT) in breast cancer (BC). In this study, we evaluated whether presence and other immune near predicts treatment outcomes across various BC subtypes. We analyzed pre- post-NAT biopsies from 104 patients using multiplex immunofluorescence (mIF) immunohistochemistry (IHC) assess distribution markers, including cells, CD68+ macrophages, FoxP3+ regulatory cells. Our findings revealed that a...
Abstract Background Increased expression of transcriptional coactivator p300 has been observed in a variety human cancers. However, the status protein/mRNA nasopharyngeal carcinoma (NPC) tissues and its clinicopathologic/prognostic implication are poorly understood. Methods In our study, mRNA protein levels was explored by reverse transcription-polymerase chain reaction (RT-PCR), Western blotting (WB) immunohistochemistry (IHC) mucosal NPC tissues. The data were analyzed receiver operating...
Glutathione S-transferase mu 3 (GSTM3) has been proven to be downregulated in renal cell carcinoma (RCC). We aimed characterise the role of GSTM3 and its genetic predisposition on occurrence postoperative prognosis RCC.The effect RCC aggressiveness was examined using transfection silencing methods. expression tissues by immunohistochemistry. The associations rs1332018 (A-63C) rs7483 (V224I) polymorphisms with risk were 400 patients 802 healthy controls. factors contributing disease-specific...
Abstract To the best of our knowledge, this is first study established a nomogram to predict survival probability in Asian patients with LSCC. A risk prediction for LSCC, incorporating easily assessable clinicopathologic factors, generates more precise estimations when compared TNM stage alone, but still need additional data before being used clinical application. Background: Due wide variation tumor behavior, laryngeal squamous cell carcinoma (LSCC) received curative-intent surgery an...
Background This study aimed to explore the potentially predictive role and dynamic changes of immune checkpoints on T cell subsets in patients with breast cancer receiving neoadjuvant chemotherapies. Methods Fluorescent multiplex immunohistochemistry (mIHC) was used stain CD4, CD8, PD1, TIM3, cytokeratins simultaneously paired samples before after therapies (NAT) a prospective cohort ( n = 50). Singleplex IHC conducted for CD3 100 cases inclusion extra retrospective 50 cases. Cell levels...
Previous studies have suggested that metformin, a biguanide family member widely used as an oral antidiabetic drug, may inhibit proliferation and induce apoptosis in certain types of cancer cell. However, the molecular mechanisms underlying metformin‑associated anticancer effects, particular antimetastatic remain to be fully understood. The present study assessed efficacy metformin inhibiting migration invasion esophageal carcinoma cell line EC109, evaluated effect on protein kinase B (AKT)...
Tau is a member of microtubule-associated proteins (MAPs) and expressed in normal breast epithelium cancer cells. expression levels early were correlated with the responsiveness taxane-containing chemotherapy. However, it unknown whether contributes to progression. Herein, recurrent metastatic (RMBC) its predictive significance palliative chemotherapy investigated. Immunohistochemical (IHC) staining was conducted detect protein biopsies from 285 patients RMBC, correlation between sensitivity...
Bacterial outer membrane vesicles (OMVs) are spherical microbubbles that contain biological content and produced by gram-negative bacteria. The use of OMVs as adjuvants for cancer immunotherapy or drug carriers targeted therapies has attracted the interest many scholars. However, it is unclear whether can exert direct antitumor effects inhibit pediatric tumors. Here, we explore potential Escherichia coli-derived to directly suppress neuroblastoma. Our results demonstrate in vitro vivo, no...
BACKGROUND: Over expression of galectin-3 (gal-3) has been associated with tumor invasion and distant metastases, but few reports investigated the relation between gal-3 prognosis in stage II colon cancer. OBJECTIVE: We studied expressions gal-3, E-cadherin, vimentin st age cancer to identify predictive factors clinical outcome. METHODS: Clinical laboratory data from 117 consecutive patients during 2008-2010 were collected analyzed retrospectively. Expressions tissue by immunohistochemistry....
Background . Long noncoding RNAs (lncRNAs), which have little or no ability to encode proteins, attracted special attention due their potential role in cancer disease. We aimed establish a lncRNA signature and nomogram incorporating the genomic clinicopathologic factors improve accuracy of survival prediction for laryngeal squamous cell carcinoma (LSCC). Methods A LSCC RNA-sequencing (RNA-seq) dataset matched information were downloaded from The Cancer Genome Atlas (TCGA). Using univariable...
How to accurately recognize the mental state of pilots is a focus in civil aviation safety. The closely related their cognitive ability piloting. Whether meets standard flight However, pilot's working unique, which increases difficulty analyzing state. In this work, we proposed Convolutional Neural Network (CNN) that merges attention classify through electroencephalography (EEG). Considering individual differences EEG, semi-supervised learning based on improved K-Means used model training...
Our study aims to develop a lncRNA-based classifier and nomogram incorporating the genomic signature clinicopathologic factors help improve accuracy of recurrence prediction for hepatocellular carcinoma (HCC) patients.The lncRNA profiling data 374 HCC patients 50 normal healthy controls were downloaded from The Cancer Genome Atlas (TCGA). Using univariable Cox regression least absolute shrinkage selection operator (LASSO) analysis, we developed 15-lncRNA-based compared our existing...
Immune characteristics were reported correlated to benefit neoadjuvant chemotherapy (NAC) in breast cancer, yet integration of comprehensive genomic alterations and T-cell receptors (TCR) predict efficacy NAC needs further investigation. This study simultaneously analyzed TMB (Tumor Mutation Burden), TCRs, TILs (tumor infiltrating lymphocyte) cancers receiving was conducted a prospective cohort (n = 22). The next-generation sequencing technology-based analysis TCR repertoire paired cancer...
Background: This study sought to test the effectiveness of EVOSKIN®Palm and sole moisturizing cream (PSMC) in preventing treating hand-foot syndrome (HFS) during capecitabine chemotherapy.Methods: Stage II/III colorectal cancer patients receiving adjuvant chemotherapy were randomly allocated receive either EVOSKINPSMC or physiological saline treatments for their hands feet. Treatment was initiated along with continued till end chemotherapy. Participants' skin responses evaluated every...
Paragonimiasis has previously been reported in many zones of China, which is the infestation trematode genus Paragonimus. The aim this study was to investigate presence and epidemiology paragonimiasis Jinhua next Fujian, China. differences Paragonimus westmani isolates from other areas world were also analyzed. Freshwater crabs snails streams located each villages dissected for isolation ofParagonimus metacercariae. data further analyzed by using geographic information systems (GIS). We...
Abstract p53 plays a pivotal role in maintaining the genomic stability of mouse embryonic stem cells (mESCs) through transcriptionally activating and repressing target genes. However, how recognizes its repressed targets remains largely unknown. Herein, we demonstrate that Sall4 negatively regulates DNA damage induced apoptosis (DIA) mESCs mediating recruitment to enhancers ESC-associated genes by from promoters p53-activated Upon damage, is an anti-apoptotic without altering activation....
Abstract Long non-coding RNAs (lncRNAs) which have little or no protein-coding capacity, due to their potential roles in the cancer disease, caught a particular interest. Our study aims develop an lncRNAs-based classifier and nomogram incorporating lncRNAs clinicopathologic factors help improve accuracy of recurrence prediction for head neck squamous cell carcinoma (HNSCC) patients. The HNSCC profiling data corresponding information were downloaded from TANRIC database cBioPortal. Using...
<title>Abstract</title> <bold>Background:</bold> In breast cancer, the spatial relationship between immune and tumor cells is increasingly recognized as critical in determining efficacy of neoadjuvant therapy (NAT). This study investigated how distribution cells, particularly CD8<sup>+</sup> T relative to affects treatment outcomes. <bold>Methods:</bold> Biopsies from 104 cancer patients were examined, both pre- post-NAT, using multiplex immunohistochemistry (mIHC). focused on density...
Introduction: The rising incidence of type 2 diabetes has seriously affected international public health. search for more drugs that can effectively treat become a cutting-edge trend in research. Coenzyme Q10 (CoQ10) attracted much attention the last decade due to its wide range biological activities. Many researchers have explored clinical effects CoQ10 patients with diabetes. However, low bio-availability high lipophilicity. Therefore, we structurally optimized an attempt exploit potential...