A5101460354- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
- Cancer Cells and Metastasis
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Genomics and Chromatin Dynamics
- Esophageal Cancer Research and Treatment
- Radiopharmaceutical Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Economic and Financial Impacts of Cancer
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Surgical Treatments
- Breast Cancer Treatment Studies
- Advanced Radiotherapy Techniques
- Nanoplatforms for cancer theranostics
- Colorectal and Anal Carcinomas
- Oral health in cancer treatment
- Curcumin's Biomedical Applications
- RNA Interference and Gene Delivery
- Medical Imaging Techniques and Applications
- Cancer Research and Treatments
Guangzhou Medical University
2010-2024
Guangzhou Medical University Cancer Hospital
2010-2024
Sun Yat-sen University
2009
Sun Yat-sen University Cancer Center
2009
Background and purposeWhether concurrent chemoradiotherapy (CCRT) benefits the older (age ≥ 60 years) patients with stage II nasopharyngeal carcinoma (NPC) has not been determined. This study aimed to compare outcomes toxicities of CCRT Intensity-Modulated Radiotherapy (IMRT) alone in NPC.Materials methodsBetween January 2010 December 2017, 220 NPC were analyzed. A pair 53 matched between group RT by using propensity score matching (PSM) terms age, sex, pathological type, T N stage, ACE-27...
Abstract Background Increased expression of transcriptional coactivator p300 has been observed in a variety human cancers. However, the status protein/mRNA nasopharyngeal carcinoma (NPC) tissues and its clinicopathologic/prognostic implication are poorly understood. Methods In our study, mRNA protein levels was explored by reverse transcription-polymerase chain reaction (RT-PCR), Western blotting (WB) immunohistochemistry (IHC) mucosal NPC tissues. The data were analyzed receiver operating...
Breast cancer stem cells are an important cause of radiotherapy resistance in the clinical treatment breast patients. How to target is key improving efficacy radiotherapy. We proposed for first time that curcumin combined with glucose nanogold particles (Glu-GNPs) targeted reduce resistance, which can significantly enhance apoptosis level MCF-7 and MDA-MB-231 stem-like (BCSCs) after antiproliferation colony-forming. Under simulated hypoxic conditions, Glu-GNPs improve ROS mammospheres;...
The aim of this study was to use four-dimensional CT (4DCT) in the planning 3D conformational external beam radiation therapy (3DCRT) for patients with early stage breast cancer. A total nine Chinese women who received conservation treatment were included study. Target localization and movement (range motion) during normal respiration assessed using ultrasound 4DCT. Plans based on 3DCT 4DCT scans developed accordance RTOG0319 guidelines dose delivery comparisons made between these plans....
Objectives: Patients with early-stage distal rectal cancer, if treated radical surgery, usually suffer a poor quality of life. Definitive radiotherapy or chemoradiotherapy may be another treatment option for them. The aim this study was to evaluate the role definitive external beam in treating cancer stage cT1-2N0. Methods: We performed retrospective 231 patients who were staged as cT1-2N0 from March 2002 2015. All by chemoradiotherapy. Overall survival (OS), progression-free (PFS), and...
To evaluate the performance of different multi-modality fusion models for predicting radiation-induced oral mucositis (RIOM) following radiotherapy in patients with nasopharyngeal carcinoma (NPC). We retrospectively collected data from 198 locally advanced NPC who experienced RIOM at Affiliated Tumor Hospital Guangzhou Medical University September, 2022 to February, 2023. Based on radiation dose-volume parameters and clinical features NPC, basic classification were developed using...
Objective To investigate efficacy and tolerability of nimotuzumab in combination with three dimensional conformal radiotherapy recurrent nasopharyngeal carcinoma.Methods 32 cases carcinoma were randomly divided into control group experimental group,16 each group.Control was treated conventional concomitant fractionated radiation (60-70 Gy 2 fractions) cycles cisplatin 20 mg/m2 (d1-4) every 3 weeks.Nimotuzumab added at a dose 100 mg i.v.weekly for 6-7 weeks the beginning group.Results The...
e14520 Background: In China, more than 95% of esophageal malignancies are squamous cell carcinoma (ESCC). We hypothesized that cetuximab would be efficacious for ESCC when given together with concurrent chemoradiation. conducted a multicenter, phase II study to investigate the safety and efficacy combined chemoradiotherapy patients locally advanced ESCC. Methods: Patients aged 18-70 years stage II-III cervical, upper thoracic midthoracic nonresectable ESCC, ECOG performance status (PS) ≤ 1...
Ubiquitin specific peptidase 22 (ubiquitin-specific processing 22,USP22),a novel deubiquitinating enzyme,is one subunit of hSAGA complexes.More and more studies have proved that USP22 is a small set cancer stem cell markers,which plays key role in the pathological process various malignant tumors' formation development closely associated with poor prognosis. Key words: Ubiquitin 22; Cancer marker; Tumors' development; Poor prognosis
Objective To observe the acute toxicity and preliminary clinical efficacy of intensify modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC).And compare it with threedimensional conformal ( 3D-CRT ). Methods From May 2008 to 2009, 51patients were treated by IMRT 2.2Gy/fraction at gross tumor volume (GTV) a total dose 70.4-74.8Gy/32-34 fraction, 1.8Gy/fraction treatment Ⅰ (CTV 1) 61.2-64.8Gy/34-36 fraction 2.0Gy/fraction Ⅱ (CTV2) 50-54Gy/25-27 fraction: 59 patients volume-nx...
Objective To assess the efficacy and appropriate timing of brain radiotherapy (BRT) combined with tyrosine kinase inhibitors (TKI) for patients who developed metastases (BM) in epidermal growth factor receptor (EGFR) mutant lung adenocarcinoma without prior TKI treatment. Method Fifty diagnosed as EGFR BM treatment were selected to analyze outcomes failure patterns. Results With a median follow-up 20 months, 1-year overall survival (OS) rate these was 82.0%, estimated OS time 23...
Abstract Objective: This study was to explore the most appropriate radiomics modeling method predict progression-free survival of EGFR-TKI treatment in advanced non-small cell lung cancer with EGFR mutations. Different machine learning methods may vary considerably and selection a proper model is essential for accurate outcome prediction. Our were established 176 discrimination models constructed 22 feature 8 classifiers. The predictive performance each evaluated using AUC, ACC,sensitivity...