A5101714070- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Peptidase Inhibition and Analysis
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Tuberculosis Research and Epidemiology
- Antimicrobial Resistance in Staphylococcus
- Gastric Cancer Management and Outcomes
- Parvovirus B19 Infection Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Asthma and respiratory diseases
- Antibiotic Resistance in Bacteria
- Viral Infections and Vectors
- Immune cells in cancer
- vaccines and immunoinformatics approaches
- interferon and immune responses
- Reproductive tract infections research
- Reproductive System and Pregnancy
- Barrier Structure and Function Studies
- Clostridium difficile and Clostridium perfringens research
- Streptococcal Infections and Treatments
- RNA modifications and cancer
Lanzhou Institute of Husbandry and Pharmaceutical Sciences
2023-2024
Beijing VDJBio (China)
2024
Taizhou University
2022
Memorial University of Newfoundland
2021
McMaster University
2014-2016
Institute for Postgraduate Medical Education
2014
People's Liberation Army 411 Hospital
2011
Chinese People's Liberation Army
2011
University of Manitoba
2006
Abstract Background The FAST study identified claudin-18 (CLDN18.2) as a promising novel therapeutic target for gastric cancer (GC). However, the tumor immune microenvironment and clinicopathological features of CLDN18.2-positive GC are unclear, making it difficult to develop optimize CLDN18.2-targeted treatments. Methods This included 80 patients, 60 whom received anti-PD-1/PD-L1 treatment. CD4/CD8/CD20/CD66b/CD68/CD163/PD-1/PD-L1/TIM-3/LAG-3/FoxP3/CTLA-4/HLA-DR/STING, CLDN18.2 were labeled...
The spatial proximity of CD8+ T cells to tumor critically influences the efficacy neoadjuvant therapy (NAT) in breast cancer (BC). In this study, we evaluated whether presence and other immune near predicts treatment outcomes across various BC subtypes. We analyzed pre- post-NAT biopsies from 104 patients using multiplex immunofluorescence (mIF) immunohistochemistry (IHC) assess distribution markers, including cells, CD68+ macrophages, FoxP3+ regulatory cells. Our findings revealed that a...
Abstract Our previous study has shown that the adoptive transfer of dendritic cells (DCs) freshly isolated from Chlamydia-infected mice (iIDCs), unlike those control naive (iNDCs), can inhibit systemic and cutaneous eosinophilia induced by OVA exposure. In present study, we examined mechanism which iIDC inhibits allergen-specific Th2 cell differentiation in vitro vivo. The revealed iIDCs exhibited higher surface expression CD8α ICOS ligand (ICOS-L), as well IL-10 IL-12 production than iNDCs....
Abstract Chlamydial infections are serious public health concerns worldwide. In this study, we examined the role of dendritic cell (DC) subsets in inducing protective immunity against chlamydial infection using an adoptive transfer approach. We found that CD11c+CD8α+ (double-positive, DP) DC, compared with CD11c+CD8α− (single-positive, SP) DC isolated from infected mice, more potent inducers immunity. Specifically, mice pretreated DPDC upon Chlamydia trachomatis mouse pneumonitis (MoPn),...
The COVID-19 pandemic has led to the influx of immunoassays for detection antibodies towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into global market. Canadian Public Health Laboratory Network Serology Task Force undertook a nationwide evaluation twelve laboratory and 6 point-of-care based commercial serological assays SARS-CoV-2 antibodies. We determined that there was considerable variability in performance individual tests an orthogonal testing algorithm should be...
Necrotizing fasciitis, caused by Streptococcus pneumoniae , is an extremely rare and life-threatening bacterial soft tissue infection. We report a case of early necrotizing fasciitis associated with infection in 26-year-old man who was immunocompromised mixed connective disease. The patient presented acute, painful, erythematous, edematous skin lesions his right lower back, which rapidly progressed to the knee. underwent surgical exploration, diagnosis confirmed pathological evidence...
West Nile neuroinvasive disease is a severe infectious that associated with high mortality rate, especially in immunocompromised hosts. Physicians who are aware of its clinical presentations may be able to order diagnostic tests more appropriately and avoid inappropriate treatment. In the present series, cases seven patients admitted Hamilton Health Sciences (Hamilton, Ontario) summer 2012 diagnosis were retrospectively reviewed based on available medical records. According laboratory...
The ability to detect antibodies severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently under investigation with various performance characteristics and indications for use. In this article, we analyzed the of Abbott SARS-CoV-2 immunoglobulin class G (IgG), EuroImmun enzyme-linked immunosorbent assay (ELISA) IgG, ELISA A (IgA) kits evidence previous infection SARS-CoV-2. We tested 49 known disease-19 (COVID-19) patients 111 prepandemic stored serology specimens. This...
Abstract Background: Anti-programmed cell death protein 1/programmed ligand 1 (anti-PD1/PDL1) based immunotherapy is the standard first-line treatment for advanced NSCLC patients without targetable driver mutations, but PDL1 immunohistochemistry (IHC) shows limited predictive value as companion diagnostics. Recent studies have elucidated a strong relationship between efficacy and tumor immune microenvironment (TIME) using single-cell multi-omics technology. In this study, we aim to develop...
<title>Abstract</title> <bold>Background:</bold> In breast cancer, the spatial relationship between immune and tumor cells is increasingly recognized as critical in determining efficacy of neoadjuvant therapy (NAT). This study investigated how distribution cells, particularly CD8<sup>+</sup> T relative to affects treatment outcomes. <bold>Methods:</bold> Biopsies from 104 cancer patients were examined, both pre- post-NAT, using multiplex immunohistochemistry (mIHC). focused on density...
e14662 Background: Immune checkpoint inhibitor (ICI) combined with anti-angiogenic therapy is the standard first-line treatment for unresectable HCC patients. However, most patients do not derive durable benefit and will progress faster. Simultaneously, sufficient clinically validated biomarkers to stratify are lacking in HCC. Recent studies have shed a light on strong connection between immunotherapy efficacy tumor immune microenvironment (TIME) Thus, this study aims investigate TIME...
Effective subunit vaccines for tuberculosis (TB) must target antigenic components at various stages of infection. In this study, we constructed fusion proteins using secreted antigens from Mycobacterium ( M. ), specifically ESAT6, CFP10, MPT64, and Rv2645 the proliferation stage, along with latency-associated Rv1738 Rv1978. The resulting proteins, designated LT33 (ESAT6-CFP10-Rv1738) LT28 (MPT64 61-170 -Rv1978 8-60 -Rv2645 21-80 were combined an adjuvant containing...
Objective To investigate the effects of macrophage inflammatory protein-1α (MIP-1α) combined with molecule 4-1BB L on tumorigenicity hepatocellular carcinoma cells in vivo. Methods Mouse MIP-1α (mMIP-1α) expressed Hepa 1-6 were transfected m4-1BBL recombinant retrovirus, anti-histidinol clones selected and amplified. The expression m4-1BB was confirmed by flow cytometry. growth curve mMIP-1α alone or together drawn compared. C57B/L Mice randomly divided into 7 groups, 9 mice each group,...
Le répertoire des tests de diagnostic disponibles du coronavirus syndrome respiratoire aigu sévère 2 (SRAS-CoV-2) évolue rapidement. Bien que les sérologiques aient une capacité limitée concernant l’infection aiguë, leur rôle dans études épidémiologiques et la prise décision en santé publique ainsi pour l’émission recommandations est plus important. Compte tenu disponibilité mondiale vaccins, laboratoires cliniques sont sollicités assurer le dépistage anticorps l’interprétation résultats...