A5023789564- Bacterial Infections and Vaccines
- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Infective Endocarditis Diagnosis and Management
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Influenza Virus Research Studies
- Mycobacterium research and diagnosis
- Virus-based gene therapy research
- Microbial infections and disease research
- Otolaryngology and Infectious Diseases
- Parasitic infections in humans and animals
- Infectious Diseases and Mycology
- HIV/AIDS drug development and treatment
- Parvovirus B19 Infection Studies
- Bacteriophages and microbial interactions
- Long-Term Effects of COVID-19
- Protein purification and stability
Moncton Hospital
2025
Dr. Georges-L.-Dumont University Hospital Centre
2013-2023
Government of New Brunswick
2019-2022
Vitalité Health Network
2022
Government of Western Australia Department of Health
2019
Public Health Agency of Canada
2014-2015
Public Health Ontario
2015
Queen Elizabeth II Health Sciences Centre
2015
Centre for Global Health Research
2007
University of Ottawa
2007
With emergence of pandemic COVID-19, rapid and accurate diagnostic testing is essential. This study compared laboratory-developed tests (LDTs) used for the detection SARS-CoV-2 in Canadian hospital public health laboratories, some commercially available real-time RT-PCR assays. Overall, analytical sensitivities were equivalent between LDTs most methods.
A large-scale, whole-genome comparison of Canadian Neisseria gonorrhoeae isolates with high-level cephalosporin MICs was used to demonstrate a genomic epidemiology approach investigate strain relatedness and dynamics. Although current typing methods have been very successful in tracing short-chain transmission gonorrheal disease, investigating the temporal evolutionary relationships geographical dissemination highly clonal lineages requires enhanced resolution only available through...
Introduction. Invasive meningococcal disease (IMD) is a nationally notifiable illness in Canada due to its potential severity and transmissibility. Vaccination strategies differ by province/territory are informed changes the antigenic characteristics of circulating strains. Gap Statement. Though IMD statistics tracked at provincial/territorial level, there lack published data characterizing trends epidemiology this national level. Aim. To examine culture-confirmed during period 2015–2023....
Antimicrobial resistance profiles were determined for Neisseria gonorrhoeae strains isolated in Canada during 2010-2014. The proportion of isolates with decreased susceptibility to cephalosporins declined significantly between 2011 and 2014, whereas azithromycin increased that period. Continued surveillance antimicrobial drug susceptibilities is imperative inform treatment guidelines.
Please cite this paper as: Van Buynder et al. (2010) Protective effect of single‐dose adjuvanted pandemic influenza vaccine in children. Influenza and Other Respiratory Viruses 4(4), 171–178. Background During the first wave A/California/7/2009(H1N1) influenza, high rates hospitalization children under 5 years were seen many countries. Subsequent policies for vaccinating varied both type number doses. In Canada, 36 months to <10 received a single dose 0·25 ml GSK (Arepanrix™) equivalent...
The incidence of antimicrobial-resistant Neisseria gonorrhoeae continues to rise in Canada; however, antimicrobial resistance data are lacking for approximately 70% gonorrhea infections that diagnosed directly from clinical specimens by nucleic acid amplification tests (NAATs). We developed a molecular assay surveillance use detect mutations genes associated with decreased susceptibility cephalosporins can be applied both culture isolates and samples. Real-time PCR assays were single...
Neurosyphilis refers to infection of the central nervous system by Treponema pallidum, which may occur at any stage. has been categorized in many ways including early and late, asymptomatic versus symptomatic infectious non-infectious. Late neurosyphilis primarily affects parenchyma, occurs beyond latent syphilis, years decades after initial infection. Associated clinical syndromes include general paresis, tabes dorsalis, vision loss, hearing loss psychiatric manifestations. Unique...
We describe 3 culture-proven cases of adenovirus serotype 14 infection in New Brunswick, Canada, during the summer 2011. Strains isolated from severely ill patients were closely related to strains a genomic variant, 14p1, circulating United States and Ireland. Physicians Canada should be aware this emerging adenovirus.
We developed a real-time PCR assay to detect single nucleotide polymorphisms associated with ciprofloxacin resistance in specimens submitted for nucleic acid amplification testing (NAAT). All three polymorphism (SNP) targets produced high sensitivity and specificity values. The presence of ≥2 SNPs was sufficient predict an organism.
Bacteremia due to Cloacibacillus species is poorly described. We present three cases involving either evryensis or porcorum. The isolates were identified by 16S rRNA gene sequencing and susceptible antibiotics commonly used for anaerobic infections. clinical significance of these organisms as potential emerging pathogens discussed.
The recent emergence of a severe respiratory disease caused by enterovirus D68 prompted investigation into whether Canadian hospital and provincial laboratories can detect this virus using commercial laboratory-developed assays. This study demonstrated analytical sensitivity differences between assays for the detection D68.
The COVID-19 pandemic has led to the influx of immunoassays for detection antibodies towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into global market. Canadian Public Health Laboratory Network Serology Task Force undertook a nationwide evaluation twelve laboratory and 6 point-of-care based commercial serological assays SARS-CoV-2 antibodies. We determined that there was considerable variability in performance individual tests an orthogonal testing algorithm should be...
INTRODUCTION: Little is known about the role of herpes simplex virus (HSV) type 1 (HSV1) in epidemiology genital Canada. Data on viral cultures for two consecutive years obtained from L’Hôpital Dr GL Dumont, which performs all culture testing New Brunswick, were reviewed. It was hypothesized that HSV1 main cause Brunswick. METHODS: Samples origin sent to laboratory HSV between July 2006 and June 2008 analyzed. an unspecified or a nongenital source excluded analysis. Multiple positive samples...
Adenovirus is a commonly isolated virus in clinical samples. Life-threatening infections, although rare, are described worldwide. An epidemic spread of an adenovirus type 3 strain occurred the province New Brunswick during fall 2008 to winter 2009; it resulted three severely ill patients, with one fatality. should be considered as cause severe community-acquired viral pneumonia, especially when influenza test negative.
Many countries have experienced increases in invasive meningococcal disease (IMD) due to a serogroup W Neisseria meningitidis (MenW) strain of the multilocus sequence type (ST)-11 clonal complex (CC). MenW ST-11 was first reported Ontario, Canada, 2014. By 2016, this caused IMD five provinces and responsible for 18.8% cases Canada.To provide an update on Canada including characteristics, specimen source isolates, age, sex geographic distribution cases.N. from culture-positive are routinely...
Background: The Gonococcal Antimicrobial Surveillance Programme is a passive surveillance system that has monitored antimicrobial resistance in Neisseria gonorrhoeae Canada since the 1980s.This article summarizes demographics, resistances and NG-MAST (N.gonorrhoeae multiantigen sequence typing) for cultures collected 2020. Methods:The National Microbiology Laboratory (NML) Winnipeg received resistant N. from provincial territorial public health laboratories.Agar dilution was used to...
In June 2005, a pilot program was implemented in Canadian laboratories to monitor the performance of Abbott human immunodeficiency virus types 1 and 2 (HIV-1/2) gO enzyme immunoassay (EIA). Two different external quality control (QC) reagents "real-time" software analysis were evaluated. November higher-than-expected calibrator rate values these kits first reported at Ontario Ministry Health (Etobicoke), followed by Alberta Provincial Public Laboratory (Edmonton Calgary) others. These...
Cestodes are emerging agents of severe opportunistic infections among immunocompromised patients. We describe the first case human infection, with recently-proposed genus Versteria causing an invasive, tumor-like hepatic infection regional and distant extension in a 53-year-old female kidney transplant recipient from Atlantic Canada.
The monitoring of antimicrobial susceptibilities in Neisseria gonorrhoeae isolates and characterization N. multiantigen sequence types (NG-MAST, ST) provide important surveillance data as resistance rates continue to rise. A total 2970 were collected by Canadian provincial public health laboratories 2010, 1233 submitted the National Microbiology Laboratory for testing. NG-MAST minimum inhibitory concentration (MIC) agar dilution determined each isolate. Of isolates, 25.1% resistant...
This study examined the phylogenetic structure of serotype a Haemophilus influenzae (Hia) isolates recovered from patients in Canada. Hia 490 separate and an American Type Culture Collection (ATCC) strain were analyzed by multilocus sequence typing (MLST), with 18 different types (STs) identified. Most (85.7%) patient typed as ST-23 another 12.7% belonged to 14 STs 6, 5, or 4 MLST gene loci related (ST-23 complex). Core genome single-nucleotide variation phylogeny (SNVPhyl) on whole (WGS)...
The development of these recommendations arose in the spring 2009