A5060745448- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Animal Virus Infections Studies
- COVID-19 and healthcare impacts
- Autopsy Techniques and Outcomes
- Virus-based gene therapy research
- Healthcare cost, quality, practices
- Chronic Myeloid Leukemia Treatments
- Extracellular vesicles in disease
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Health Literacy and Information Accessibility
- Chronic Kidney Disease and Diabetes
- Hematopoietic Stem Cell Transplantation
- Global Cancer Incidence and Screening
- Central Venous Catheters and Hemodialysis
- Meningioma and schwannoma management
- Single-cell and spatial transcriptomics
- Data-Driven Disease Surveillance
- COVID-19 diagnosis using AI
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
North West London Pathology
2020-2025
Imperial College London
2018-2025
Imperial College Healthcare NHS Trust
2019-2024
Charing Cross Hospital
2021-2024
The Francis Crick Institute
2024
Access to Wholistic and Productive Living Institute
2023
Genomics England
2020
RELX Group (United States)
2020
Maidstone and Tunbridge Wells NHS Trust
2019
Yukon Health and Social Services
2019
SummaryBackgroundSevere COVID-19 has a high mortality rate. Comprehensive pathological descriptions of are scarce and limited in scope. We aimed to describe the histopathological findings viral tropism patients who died severe COVID-19.MethodsIn this case series, were considered eligible if they older than 18 years, with premortem diagnosis acute respiratory syndrome coronavirus 2 infection listed clinically as direct cause death. Between March 1 April 30, 2020, full post-mortem examinations...
Summary SARS-CoV-2 enters cells via its spike glycoprotein which must be cleaved sequentially at the S1/S2, then S2’ cleavage sites (CS) to mediate membrane fusion. has a unique polybasic insertion S1/S2 CS, we demonstrate can by furin. Using lentiviral pseudotypes and cell-culture adapted virus with deletion, show that is selected for in lung primary human airway epithelial cultures but against Vero E6, cell line used passaging SARS-CoV-2. We find this selective advantage depends on...
The most common cause of death due to COVID-19 remains respiratory failure. Yet, our understanding the precise cellular and molecular changes underlying lung alveolar damage is limited. Here, we integrate single cell transcriptomic data donor tissue with spatial stratifying histopathological stages diffuse damage. We identify in composition across progressive damage, including waves molecularly distinct macrophages depletion epithelial endothelial populations. Predicted markers pathological...
SARS-CoV-2, the causative agent of COVID-19, typically manifests as a respiratory illness, although extrapulmonary involvement, such in gastrointestinal tract and nervous system, well frequent thrombotic events, are increasingly recognised. How this maps onto SARS-CoV-2 organ tropism at histological level, however, remains unclear. Here, we perform comprehensive validation monoclonal antibody against nucleocapsid protein (NP) followed by systematic multisystem immunohistochemistry analysis...
Many countries have experienced increases in invasive meningococcal disease (IMD) due to a serogroup W Neisseria meningitidis (MenW) strain of the multilocus sequence type (ST)-11 clonal complex (CC). MenW ST-11 was first reported Ontario, Canada, 2014. By 2016, this caused IMD five provinces and responsible for 18.8% cases Canada.To provide an update on Canada including characteristics, specimen source isolates, age, sex geographic distribution cases.N. from culture-positive are routinely...
Thrombotic accumulation is associated with surface interactions between blood proteins and vascular access devices. Catheter occlusion results from this process, a costly, common, occurrence peripherally inserted central catheters (PICCs). Hydrophilic catheter materials exhibit antithrombotic properties. This retrospective study evaluates the of PICCs constructed poly(vinyl alcohol)-based hydrogel composite known as hydrophilic biomaterial (HBM), compared to thermoplastic polyurethane (TPU)...
Hospital (consented) autopsy rates have dropped precipitously in recent decades. Online medical information is now a common resource used by the general public. Given clinician reluctance to request hospital postmortem examinations, we assessed whether healthcare users access high quality, readable online.A cross-sectional analysis of 400 webpages. Readability was determined using Flesch-Kincaid score, grade level and Coleman-Liau Index. Authorship, DISCERN score Journal American Medical...
This study examines the histological findings of tracheal tissue samples obtained from COVID-19 positive mechanically ventilated patients, to assess degree inflammation/ulceration present.Retrospective single-centre observational cohort study. All patients admitted Adult Intensive Care Unit (AICU) with infection, requiring mechanical ventilation and surgical tracheostomy between 1 April May 2020, were included (Group 1). Tracheal windows excised at underwent analysis. Comparison was made...
Post-mortem examinations continue to play a crucial role in understanding the epidemiology and pathogenesis of infectious diseases. However, perceived infection risk can preclude traditional, invasive, complete diagnostic autopsy. examination is especially important emerging diseases with potentially unknown risks, but rapid acquisition good quality tissue samples needed as part scientific public health response. Needle biopsy post-mortem minimally rapid, closed-body autopsy technique that...
<title>Abstract</title> Accumulating evidence suggests dysregulated immune checkpoint (IC) signaling can exacerbate COVID-19 severity, but the role of these molecules in pathogenesis fatal COVID-19-related diffuse alveolar damage (DAD) remains elusive. Understanding how IC proteins influence acute lung injury due to provide insights into potential therapeutic strategies modulate responses and improve patient outcomes. Here, a single-center autopsy cohort, we determined cellular localization...
Since the introduction of imatinib, first oral tyrosine kinase inhibitor (TKI) targeting Philadelphia Chromosome, prognosis in chronic myelogenous leukaemia (CML) has dramatically improved.1 Although there have been multiple reports demonstrating a T/Natural Killer (NK) cell monoclonal lymphocytosis with use dasatinib and some studies showing small increased risk second malignancies TKIs CML, an association between nilotinib rare haematological not established.2–6 Herein, we report case...