Lei Yan

ORCID: 0000-0002-4779-2688
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About
Contact & Profiles
Research Areas
  • Market Dynamics and Volatility
  • COVID-19 Clinical Research Studies
  • Long-Term Effects of COVID-19
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 and Mental Health
  • Monetary Policy and Economic Impact
  • Software Testing and Debugging Techniques
  • Global Energy and Sustainability Research
  • Energy, Environment, Economic Growth
  • Natural Resources and Economic Development
  • Microstructure and Mechanical Properties of Steels
  • COVID-19 and healthcare impacts
  • Vaccine Coverage and Hesitancy
  • Software System Performance and Reliability
  • Metallurgy and Material Forming
  • COVID-19 diagnosis using AI
  • Metal Alloys Wear and Properties
  • Respiratory viral infections research
  • HIV-related health complications and treatments
  • Software Engineering Research
  • Cryptography and Data Security
  • VLSI and Analog Circuit Testing
  • Medical Research and Treatments
  • Privacy-Preserving Technologies in Data
  • Metallic Glasses and Amorphous Alloys

VA Connecticut Healthcare System
2022-2025

Yale University
2018-2025

Nanjing University of Posts and Telecommunications
2024

Chongqing University
2017-2024

Chang'an University
2024

Health Services Research & Development
2023-2024

Jiangsu University of Science and Technology
2007-2024

The University of Texas Health Science Center at San Antonio
2024

Peng Cheng Laboratory
2023

Ministry of Education of the People's Republic of China
2022

ABSTRACT Background Information about the effectiveness of oral antivirals in preventing short- and long-term COVID-19-related outcomes during Omicron surge is limited. We sought to determine nirmatrelvir-ritonavir molnupiravir for outpatient treatment COVID-19. Methods conducted three retrospective target trial emulation studies comparing matched patient cohorts who received versus no treatment, Veterans Health Administration (VHA). Participants were VHA care at risk severe COVID-19 tested...

10.1101/2022.12.05.22283134 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2022-12-06

This paper presents a novel automated test case generation framework leveraging deep reinforcement learning (DRL) for chip verification. The addresses the growing complexity in modern designs where traditional verification methods must help achieve comprehensive coverage efficiently. Our approach implements custom Q-network architecture optimized processing feedback and generating vectors, incorporating an innovative reward mechanism that balances optimization with simulation efficiency....

10.60087/jklst.v4.n1.001 article EN cc-by Journal of Knowledge Learning and Science Technology ISSN 2959-6386 (online) 2025-01-25

Monovalent COVID-19 vaccines targeting the XBB.1.5 Omicron variant were introduced in September 2023. In absence of randomized controlled trials demonstrating their efficacy, information on real-world vaccine effectiveness (VE) is needed. To determine VE and extent to which it declines over time. Target trial emulation. U.S. Veterans Health Administration. Eligible recipients matched 1:1 unvaccinated persons 7 sequential biweekly with enrollment from 2 October 2023 through 3 January 2024....

10.7326/annals-24-01015 article EN Annals of Internal Medicine 2025-02-04

Importance Several pharmacotherapies have been authorized to treat nonhospitalized persons with symptomatic COVID-19. Longitudinal information on the use of these therapies is needed. Objective To analyze trends and factors associated prescription outpatient COVID-19 within Veterans Health Administration (VHA). Design, Setting, Participants This cohort study evaluated veterans in VHA care who tested positive for SARS-CoV-2 from January 2022 through 2023 using linked Community Care Medicare...

10.1001/jamanetworkopen.2023.31249 article EN cc-by-nc-nd JAMA Network Open 2023-08-31

Importance SARS-CoV-2, influenza, and respiratory syncytial virus (RSV) contribute to many hospitalizations deaths each year. Understanding relative disease severity can help inform vaccination guidance. Objective To compare of COVID-19, RSV among US veterans. Design, Setting, Participants This retrospective cohort study analyzed national Veterans Health Administration electronic health record data nonhospitalized veterans who underwent same-day testing for RSV, were diagnosed with a single...

10.1001/jamainternmed.2024.7452 article EN JAMA Internal Medicine 2025-01-27

Abstract Background Coronavirus disease 2019 (COVID-19) has been linked to the development of post–COVID-19 conditions (PCCs). We investigated whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection increases risk selected PCCs or death up 1 year after infection, separately in wild-type (WT), Alpha-transition, Delta, and Omicron eras by vaccination status. Methods used health records Veterans Health Administration emulate a hypothetical target trial SARS-CoV-2 versus...

10.1093/cid/ciaf087 article EN Clinical Infectious Diseases 2025-04-10

Nirmatrelvir-ritonavir is recommended for persons at risk severe coronavirus disease 2019 (COVID-19) but remains underutilized. Information on which eligible groups are likely to benefit from treatment needed.

10.1093/cid/ciae202 article EN public-domain Clinical Infectious Diseases 2024-06-12

10.1016/j.jcomm.2017.10.002 article EN Journal of commodity markets 2017-10-18

Importance Older adults and individuals with medical comorbidities are at increased risk for severe COVID-19. Several pharmacotherapies demonstrated to reduce the of COVID-19–related hospitalization death have been authorized use. Objective To describe factors associated receipt outpatient COVID-19 in Veterans Affairs (VA) health care system. Design, Settings, Participants This cohort study assessed veterans who tested positive SARS-CoV-2 during January February 2022. The setting was VA...

10.1001/jamanetworkopen.2022.41434 article EN cc-by-nc-nd JAMA Network Open 2022-11-11

Background Widowhood is one of the most serious issues affecting mental health older persons. China currently has tens millions widowed adult, which a huge group. It great significance to study impacts widowhood on their and put forward some measures for improvement. Method We used Family Panel Studies (CFPS) data in 2020, included 4,184 adults. Linear regression examine relationship among widowhood, health, social capital. Results Both short-term medium- long-term lead significant increase...

10.3389/fpubh.2024.1385592 article EN cc-by Frontiers in Public Health 2024-04-24
Katrina Hauschildt David Bui Diana J. Govier Tammy L. Eaton Elizabeth M. Viglianti and 95 more Catherine K. Ettman Holly McCready Valerie A. Smith Ann M. O’Hare Thomas F. Osborne Edward J. Boyko George N. Ioannou Matthew L. Maciejewski Amy S. B. Bohnert Denise M. Hynes Theodore J. Iwashyna Wen Lin Chai Barrett Bowling Matthew L. Maciejewski James Womer Theodore J. Iwashyna Stacy Anderson Taylor Bernstein Aissa Cabrales Katrina Hauschildt Andrew J. Admon Kaitland M. Byrd Jennifer Cano Jeffrey R. Curtis Emily DelMonico Dana Horowitz Lee Kamphius Peggy Korpela Kyle Kumbier Kenneth M. Langa Hallie C. Prescott Marylena Rouse Sameer D. Saini Sarah Seelye Jeremy B. Sussman Natalya Wawrin Max Monahan Amy S. B. Bohnert Elizabeth M. Viglianti Kathleen M. Akgün Mihaela Aslan Kei‐Hoi Cheung Yuli Li Pradeep Mutalik Nallakkandi Rajeevan Lei Yan Livia Anderson Theodore S. Z. Berkowitz Joseph Bogdan Hayden B. Bosworth Nathan A. Boucher Graham Cummin Paul A. Dennis Breana Floyd Susan N. Hastings Brystana G. Kaufman Cassie Meyer Amy Miles Jennifer C. Naylor Megan Shepherd‐Banigan Valerie A. Smith Battista Smith Christopher Woods Aram Dobalian Matthew Bidwell Goetz Kevin S Ikuta Michael Ong Aasma Shaukat Lisa I. Backus Jacqueline M. Ferguson Thomas F. Osborne Troy A. Shahoumian Zachary Veigulis Donna M. Zulman Kristina L. Bajema David Bui Jason I. Chen Diana J. Govier Mark Helfand Alex Hickok Catherine L. Hough Holly McCready Abby Moss Summer Newell Meike Niederhausen Shannon M. Nugent Somnath Saha Christopher G. Slatore Yumie Takata Alan R. Teo Anaïs Tuepker Kelly C. Vranas Kara Winchell Denise M. Hynes Edward J. Boyko

Abstract Geographic variation in hardship, especially health-related was identified prior to and during the pandemic, but we do not know whether this is consistent among Veterans Health Administration (VHA)–enrolled veterans, who reported markedly high rates of financial hardship despite general veteran-specific federal policy efforts aimed at reducing hardship. In a nationwide, regionally stratified sample VHA-enrolled examined prevalence pandemic varied by US Census region. We found...

10.1093/haschl/qxae075 article EN cc-by-nc Health Affairs Scholar 2024-05-30

Physical unclonable function (PUF) is a reliable physical security primitive. The Weak PUF and Strong are two well-known topologies. can be used to authenticate protect intellectual property on FPGA chips. Classic designs, like arbiter PUF, hard implement severely threatened by the machine learning based modeling attacks. In this work, we propose new combining with obfuscation logic. Experiment results 28 nm show that resistance attack good hardware overhead small.

10.1587/elex.16.20190695 article EN IEICE Electronics Express 2019-01-01

Automated fault localization (FL) techniques collect runtime information as input data and then analyze to identify the relationship between program statements failures. They usually take advantages of statistics develop a suspiciousness evaluation methodology (e.g., spectrum-based formulas deep neural network models) by exploring underlying correlation rooted in data. Thus, quality is critical for FL. In actual process development, developers seek generate adequate test cases testing...

10.1109/saner53432.2022.00045 article EN 2022 IEEE International Conference on Software Analysis, Evolution and Reengineering (SANER) 2022-03-01

The Omicron variant is characterized by striking infectivity and antibody evasion. analysis of BA.2 infection risk factors limited among geriatric individuals understanding these would promote improvement in the public health system reduction mortality. Therefore, our research investigated for discriminating severe/critical from mild/moderate patients. Baseline characteristics enrolled patients (aged over 60 years) with infections were analyzed. A logistic regression was conducted to...

10.3389/fmed.2022.1018516 article EN cc-by Frontiers in Medicine 2022-12-19

Abstract Commodity index rolling is treated as a natural experiment and an event study of order flow costs in wide array futures markets conducted. The spread between nearby deferred prices decreases significantly the early growth phases financialization (1991–2011), with spreads reversing back after completed. Spread impacts disappear post‐financialization period (2012–2019). We argue that dramatic increase supply liquidity brought on by transition to electronic trading commodity primarily...

10.1002/aepp.13297 article EN Applied Economic Perspectives and Policy 2022-06-08

In the construction of Shenzhen–Zhongshan Link, a temporary anchorage system, distributed uniformly along pipe wall, has been employed. To assess safety and reliability this combined method utilizing numerical analysis model experiments was applied to study system tension rods. Firstly, an overall caisson segment based on GINA rebound force established analyze stress state entire system. Secondly, comprehensive experiment verification were conducted for single tensioning revealing its...

10.1016/j.jtte.2024.04.002 article EN cc-by-nc-nd Journal of Traffic and Transportation Engineering (English Edition) 2024-07-26
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