Denise M. Hynes

ORCID: 0000-0002-6436-7157
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About
Contact & Profiles
Research Areas
  • Primary Care and Health Outcomes
  • Healthcare Policy and Management
  • Health Systems, Economic Evaluations, Quality of Life
  • COVID-19 Clinical Research Studies
  • COVID-19 and Mental Health
  • Chronic Disease Management Strategies
  • Long-Term Effects of COVID-19
  • Dialysis and Renal Disease Management
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 and healthcare impacts
  • Patient Satisfaction in Healthcare
  • Global Health Care Issues
  • Economic and Financial Impacts of Cancer
  • Health disparities and outcomes
  • Emergency and Acute Care Studies
  • Vaccine Coverage and Hesitancy
  • Erythropoietin and Anemia Treatment
  • Geriatric Care and Nursing Homes
  • Global Cancer Incidence and Screening
  • Electronic Health Records Systems
  • Health Policy Implementation Science
  • Medical Coding and Health Information
  • Cardiac, Anesthesia and Surgical Outcomes
  • Intensive Care Unit Cognitive Disorders
  • Hernia repair and management

VA Portland Health Care System
2018-2025

Oregon Health & Science University
2022-2025

Oregon State University
2018-2025

Portland VA Medical Center
2018-2025

Seton Hall University
2025

Health Services Research & Development
2000-2024

United States Department of Veterans Affairs
2004-2024

Duke University
2005-2024

VA Palo Alto Health Care System
2024

University of Michigan–Ann Arbor
2024

One of the national mortality databases in U.S. is Beneficiary Identification and Record Locator Subsystem (BIRLS) Death File that contains death dates those who have received any benefits from Department Veterans Affairs (VA). The completeness this database was shown to vary widely cohort previous studies. Three other sources are available VA can complement BIRLS File. objective study evaluate accuracy four examine whether these be combined into a with improved accuracy.A random sample...

10.1186/1478-7954-4-2 article EN cc-by Population Health Metrics 2006-04-10

We examined the impact of access to care characteristics on health use patterns among those veterans dually eligible for Medicare and Veterans Affairs (VA) services.We used a retrospective, cross-sectional design identify who were VA in calendar year 1999. analyzed national utilization claims data. descriptive multivariable generalized ordered logit analyses examine how patient, geographic, environmental factors affect percent reliance inpatient outpatient services.Of 1.47 million our study...

10.1097/01.mlr.0000244657.90074.b7 article EN Medical Care 2007-02-15

Some persons infected with SARS-CoV-2 experience symptoms or impairments many months after acute infection.To determine the rates, clinical setting, and factors associated documented receipt of COVID-19-related care 3 more infection.This retrospective cohort study used data from US Department Veterans Affairs health system. Participants included a positive test between February 1, 2020, April 30, 2021, who were still alive infection did not have evidence reinfection. Data analysis was...

10.1001/jamanetworkopen.2022.24359 article EN cc-by-nc-nd JAMA Network Open 2022-07-29

ABSTRACT Background Information about the effectiveness of oral antivirals in preventing short- and long-term COVID-19-related outcomes during Omicron surge is limited. We sought to determine nirmatrelvir-ritonavir molnupiravir for outpatient treatment COVID-19. Methods conducted three retrospective target trial emulation studies comparing matched patient cohorts who received versus no treatment, Veterans Health Administration (VHA). Participants were VHA care at risk severe COVID-19 tested...

10.1101/2022.12.05.22283134 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2022-12-06

Importance There is increasing recognition of the long-term health effects SARS-CoV-2 infection (sometimes called long COVID ). However, little yet known about clinical diagnosis and management within systems. Objective To describe dominant themes pertaining to in electronic records (EHRs) patients with a diagnostic code for this condition ( International Statistical Classification Diseases Related Health Problems, Tenth Revision [ ICD-10 ] U09.9). Design, Setting, Participants This...

10.1001/jamanetworkopen.2022.40332 article EN cc-by-nc-nd JAMA Network Open 2022-11-03
Theodore J. Iwashyna Sarah Seelye Theodore S. Z. Berkowitz John Pura Amy S. B. Bohnert and 95 more C. Barrett Bowling Edward J. Boyko Denise M. Hynes George N. Ioannou Matthew L. Maciejewski Ann M. O’Hare Elizabeth M. Viglianti James Womer Hallie C. Prescott Valerie A. Smith Andrew J. Admon Kathleen M. Akgün Stacy Anderson Mihaela Aslan David H. Au Lisa I. Backus Kristina L. Bajema Aaron Baraff Lisa Batten Theodore S. Z. Berkowitz Taylor Bernstein Kristin Berry Wyatt Joseph Bogdan Hayden B. Bosworth Nathan A. Boucher Nicholas Burwick Aissa Cabrales Jennifer Cano Wen Lin Chai Jason I. Chen Kei‐Hoi Cheung Kristina Crothers Jeffrey R. Curtis Marie Davis Emily Del Monico Aram Dobalian Jacob A. Doll Jason A. Dominitz McKenna C. Eastment Vincent S. Fan Jacqueline M. Ferguson Breanna Floyd Alexandra Fox Matthew Bidwell Goetz Diana J. Govier Pamela Green Susan N. Hastings Katie Hauschildt Eric J. Hawkins Paul L. Hebert Mark Helfand Alex Hickok Dana Horowitz Catherine L. Hough Elaine Hu Kevin S Ikuta Barbara Jones Makoto Jones Lee Kamphuis Brystana G. Kaufman Sara J. Knight Anna Korpak Peggy Korpela Kyle Kumbier Kenneth M. Langa Ryan J. Laundry Stacy Lavin Yuli Li Jennifer Linquist Holly McCready Martha Michel Amy Miles Jessie Milne Max Monahan Daniel Alexandre Morelli Pradeep Mutalik Jennifer C. Naylor Meike Neiderhausen Summer Newell Shannon M. Nugent Michael Ong Thomas F. Osborne Matthew Peterson Alexander C. Peterson Nallakkandi Rajeevan Ashok Reddy Marylena Rouse Mazhgan Rowneki Som Saha Sameer D. Saini Javeed A. Shah Troy A. Shahoumian Aasma Shaukat Megan Shepherd‐Banigan Whitney Showalter

Importance Despite growing evidence of persistent problems after acute COVID-19, how long the excess mortality risk associated with COVID-19 persists is unknown. Objective To measure time course differential among Veterans who had a first-documented infection by separately assessing from later matched groups infected and uninfected individuals survived were uncensored at start each period. Design, Settings, Participants This retrospective cohort study used prospectively collected health...

10.1001/jamainternmed.2023.3587 article EN cc-by JAMA Internal Medicine 2023-08-21

Care coordination is crucial to avoid potential risks of care fragmentation in people with complex needs. While there are many empirical and conceptual approaches measuring improving coordination, use theory limited by its complexity the wide variability available frameworks. We systematically identified categorized existing theoretical frameworks new ways make theory-to-practice link more accessible. To identify relevant frameworks, we searched MEDLINE®, Cochrane, CINAHL, PsycINFO, SocINDEX...

10.1007/s11606-019-04966-z article EN cc-by-nc-sa Journal of General Internal Medicine 2019-05-01

Little is known about real-world COVID-19 vaccine effectiveness (VE) in racially and ethnically diverse, elderly populations with high comorbidity burden.To determine the of messenger RNA vaccines.Target trial emulation study comparing newly vaccinated persons matched unvaccinated controls.U.S. Department Veterans Affairs health care system.Among receiving system (n = 5 766 638), those who received at least 1 dose Moderna or Pfizer-BioNTech from 11 December 2020 to 25 March 2021 2 099 871)...

10.7326/m21-3256 article EN Annals of Internal Medicine 2021-12-20

The effectiveness of a third mRNA COVID-19 vaccine dose (booster dose) against the Omicron (B.1.1.529) variant is uncertain, especially in older, high-risk populations.To determine booster (VE) SARS-CoV-2 infection, hospitalization, and death era by type, primary time since vaccination, age, comorbidity burden.Retrospective matched cohort study designed to emulate target trial vaccination versus no booster, conducted from 1 December 2021 31 March 2022.U.S. Department Veterans Affairs health...

10.7326/m22-1856 article EN Annals of Internal Medicine 2022-10-10

Inferior outcomes after kidney transplantation among African Americans are poorly understood. It was hypothesized that unequal access to medical care transplant recipients might contribute worse posttransplantation and racial disparities in would be less pronounced patients who receive health within versus outside the Department of Veterans Affairs (VA), because eligible veterans VA entitled universal care, including coverage prescription drugs. A study cohort 79,361 were undergoing their...

10.1681/asn.2004040333 article EN Journal of the American Society of Nephrology 2004-11-25

Patient race in the Department of Veterans Affairs (VA) information system was previously recorded based on an administrative or clinical employee's observation. Since 2003, VA started to collect self-reported compliance with a new federal guideline. We investigated implications this transition for using race/ethnicity data multi-year trends and other healthcare systems that make transition.All unique users services 2004 were compared their prior observer-recorded from 1997-2002 (N =...

10.1186/1478-7954-4-7 article EN cc-by Population Health Metrics 2006-07-06

A Department of Veterans Affairs Cooperative Study randomized high-risk patients with medically refractory myocardial ischemia, a group largely excluded from previous trials, to urgent revascularization either percutaneous coronary intervention (PCI) or artery bypass grafting (CABG). The present study examined the cost-effectiveness PCI versus CABG for these patients.Of 454 at 16 medical centers, 445 were available economic analysis (218 and 227 patients). Total costs assessed 3 5 years...

10.1161/circulationaha.105.570838 article EN Circulation 2006-09-12

The distributions of medical costs are often skewed to the right because small numbers patients use large amounts health care resources. Using data from a study colon cancer costs, we show, by example, impact and magnitude outliers influential observations on compared effects statistical costing methods for addressing disproportionate influence observations. We used retrospective cohort 3,842 elderly veterans with who were enrolled in from, both Department Veterans Affairs Medicare...

10.1186/2193-1801-2-614 article EN SpringerPlus 2013-11-18

Objective: To examine care system choices for Veterans dually-eligible VA and Medicare FFS following changes in eligibility policy, which expanded availability of

10.5600/mmrr.002.03.a06 article EN Medicare & Medicaid Research Review 2012-01-01

The Chicago Area Patient-Centered Outcomes Research Network (CAPriCORN) represents an unprecedented collaboration across diverse healthcare institutions including private, county, and state hospitals health systems, a consortium of Federally Qualified Health Centers, two Department Veterans Affairs hospitals. CAPriCORN builds on the strengths our to develop cross-cutting infrastructure for sustainable patient-centered comparative effectiveness research in Chicago. Unique aspects include with...

10.1136/amiajnl-2014-002827 article EN cc-by-nc Journal of the American Medical Informatics Association 2014-05-13

Importance Several pharmacotherapies have been authorized to treat nonhospitalized persons with symptomatic COVID-19. Longitudinal information on the use of these therapies is needed. Objective To analyze trends and factors associated prescription outpatient COVID-19 within Veterans Health Administration (VHA). Design, Setting, Participants This cohort study evaluated veterans in VHA care who tested positive for SARS-CoV-2 from January 2022 through 2023 using linked Community Care Medicare...

10.1001/jamanetworkopen.2023.31249 article EN cc-by-nc-nd JAMA Network Open 2023-08-31

Monovalent COVID-19 vaccines targeting the XBB.1.5 Omicron variant were introduced in September 2023. In absence of randomized controlled trials demonstrating their efficacy, information on real-world vaccine effectiveness (VE) is needed. To determine VE and extent to which it declines over time. Target trial emulation. U.S. Veterans Health Administration. Eligible recipients matched 1:1 unvaccinated persons 7 sequential biweekly with enrollment from 2 October 2023 through 3 January 2024....

10.7326/annals-24-01015 article EN Annals of Internal Medicine 2025-02-04
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