A5091258721- Pulmonary Hypertension Research and Treatments
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Innovations in Medical Education
- COVID-19 and Mental Health
- Emergency and Acute Care Studies
- Intensive Care Unit Cognitive Disorders
- Family and Patient Care in Intensive Care Units
- Migration, Health and Trauma
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Simulation-Based Education in Healthcare
- Cardiovascular and exercise physiology
- Cancer Immunotherapy and Biomarkers
- Advanced MRI Techniques and Applications
- Airway Management and Intubation Techniques
- Vascular Anomalies and Treatments
- Interpreting and Communication in Healthcare
- SARS-CoV-2 and COVID-19 Research
- Cardiac Health and Mental Health
- COVID-19 and healthcare impacts
- Cardiac Arrest and Resuscitation
- Health, Nursing, Elderly Care
- Congenital Heart Disease Studies
- Cardiac tumors and thrombi
Massachusetts General Hospital
2015-2024
Harvard University
2013-2024
Pulmonary and Critical Care Associates
2019-2023
Lemuel Shattuck Hospital
2021
Universidade Federal de São Paulo
2018
Medical University of Graz
2018
Brown University
2018
Ludwig Boltzmann Institute for Lung Vascular Research
2018
Boston Children's Hospital
2018
VA Boston Healthcare System
2018
TGF-β–independent oxidative modification of NEDD9 at Cys 18 promotes vascular fibrosis and the pathobiology pulmonary arterial hypertension.
Dyspnea and exercise intolerance are commonly reported post-acute sequelae of SARS-CoV-2 infection (PASC), but routine diagnostic testing is often normal. Cardiopulmonary (CPET) offers comprehensive assessment dyspnea to characterize pulmonary PASC.We performed a retrospective cohort study CPET on patients reporting and/or following confirmed Covid-19 between August 1, 2020 March 2021, compared them age- sex-matched with unexplained referred for at the same center in pre-Covid-19...
Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for disease 2019 (COVID-19), may experience lasting sequelae following phase of their index infection.1 The post-acute SARS-CoV-2 infection (PASC) can manifest as a wide-ranging constellation disabling symptoms. These symptoms are sometimes referred to being part long COVID, COVID-19 syndrome, long-haul chronic or other terms, but purposes this report, term PASC will be used....
Rationale: The leading cause of death in coronavirus disease 2019 (COVID-19) is severe pneumonia, with many patients developing acute respiratory distress syndrome (ARDS) and diffuse alveolar damage (DAD). Whether DAD fatal COVID-19 distinct from other causes remains unknown. Objective: To compare lung parenchymal vascular alterations between pneumonia DAD-causing etiologies using a multidimensional approach. Methods: This autopsy cohort consisted consecutive (n = 20) failure histologic 21;...
Rationale: Current methods assessing clinical risk because of exercise intolerance in patients with cardiopulmonary disease rely on a small subset traditional variables. Alternative strategies incorporating the spectrum factors underlying prognosis at-risk may be useful clinically, but are lacking. Objective: Use unbiased analyses to identify variables that correspond intolerance. Methods and Results: Data from 738 consecutive referred for invasive testing at single center (2011–2015) were...
Compared to healthy volunteers, participants with post-acute sequelae of SARS-CoV-2 infection (PASC) demonstrated increased plasma levels the prothrombotic protein NEDD9, which associated inversely indices pulmonary vascular function. This suggests persistent dysfunction may play a role in pathobiology PASC.
Objectives Ultrasonography is of growing importance within internal medicine (IM), but the optimal method training doctors to use it uncertain. In this study, authors provide first objective comparison two approaches IM residents in ultrasonography. Methods randomised trial, a simulation-based ultrasound curriculum was implemented during intern orientation at tertiary care teaching hospital. All 72 incoming interns attended lecture and were given access online modules. Interns then randomly...
Rationale: Data on the molecular mechanisms that regulate platelet-pulmonary endothelial adhesion under conditions of hypoxia are lacking, but may have important therapeutic implications. Objectives: To identify a hypoxia-sensitive, modifiable mediator artery cell and thrombotic remodeling. Methods: Network medicine was used to profile protein-protein interactions in hypoxia-treated human pulmonary cells. from liquid chromatography-mass spectrometry microscale thermophoresis informed...
BackgroundPost-COVID-19 clinics were implemented to improve postacute care for patients with COVID-19, including survivors of critical illness, many whom experience post-intensive syndrome (PICS). Whether changed over the course pandemic and if inequities in utilization exist remain unclear.Research QuestionAmong COVID-19 what patterns postdischarge during different waves, are there outpatient utilization?Study Design MethodsIn this retrospective cohort study, we describe sociodemographics,...
Residency training is charged with improving resident teaching skills. Utilizing simulation in teacher has unique advantages such as providing a controlled learning environment and opportunities for deliberate practice.We assessed the impact of simulation-based resident-as-teacher (RaT) program.A RaT program was embedded an existing 8-case curriculum 52 internal medicine (IM) interns. Residents participated workshop, then served facilitators received feedback from faculty.Residents' feed...
Abstract The pathobiology of in situ pulmonary thrombosis acute respiratory distress syndrome (ARDS) due to severe coronavirus‐2 (SARS‐CoV‐2) infection is incompletely characterized. In human artery endothelial cells (HPAECs), hypoxia increases neural precursor cell expressed, developmentally downregulated 9 (NEDD9) and induces expression a prothrombotic NEDD9 peptide (N9 P ) on the extracellular plasma membrane surface. We hypothesized that SARS‐CoV‐2–ARDS pathophenotype involves increased...
Severe acute respiratory syndrome coronavirus 2, the virus responsible for COVID-19, has placed unprecedented strain on healthcare system in United States and worldwide. The resultant surge of patients with COVID-19 presented hospitals unique challenges respect to infrastructure, supply chain disruptions, capacity, staffing, triage. Intensive care unit (ICU) teams have increased their often unfamiliar geographically distant locations, ensure critically ill requiring prolonged mechanical...
Code status orders impact clinical outcomes as well patients' and surrogates' experiences. This is the first multicenter cohort examining code of ICU patients with COVID-19 reported to date.This a retrospective study including adult who tested positive for SARS-CoV-2 were admitted at three hospitals in Massachusetts from March 11, 2020 - May 31, 2020. We examined differences multiple timepoints performed multivariable regression analysis identify variables associated admission.Among 459...
Abstract Background Stimulant use has increased across the US, with concomitant opioid and methamphetamine doubling between 2011 2017. Shifting patterns of polysubstance have led to rising psychostimulant-involved deaths. While it is known that individuals who require greater access treatment, there still little about treatment among are already engaged in outpatient substance treatment. Objectives To characterize care-engaged guide harm reduction strategies. Methods Retrospective cohort...