A5078640294- Alzheimer's disease research and treatments
- COVID-19 Clinical Research Studies
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Long-Term Effects of COVID-19
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Infectious Encephalopathies and Encephalitis
- Hematological disorders and diagnostics
- Head and Neck Surgical Oncology
- Inflammatory Myopathies and Dermatomyositis
- Cell Image Analysis Techniques
- Retinal and Optic Conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Histiocytic Disorders and Treatments
- Metabolomics and Mass Spectrometry Studies
- Neurological Complications and Syndromes
- Ocular Diseases and Behçet’s Syndrome
- Polyomavirus and related diseases
- Neurogenesis and neuroplasticity mechanisms
- Ophthalmology and Eye Disorders
- Muscle Physiology and Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Cholinesterase and Neurodegenerative Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
Massachusetts General Hospital
2019-2024
Harvard University
2019-2024
Florida State University
2023
Dade County Medical Examiner Department
2022
Miami Dade College
2022
We evaluated the incidence, distribution, and histopathologic correlates of microvascular brain lesions in patients with severe COVID-19. Sixteen consecutive admitted to intensive care unit COVID-19 undergoing MRI for evaluation coma or neurologic deficits were retrospectively identified. Eleven had punctate susceptibility-weighted imaging (SWI) subcortical deep white matter, eight >10 SWI lesions, four involving corpus callosum. The distribution was similar that seen hypoxic respiratory...
Microvascular lesions are common in patients with severe COVID-19. Radiologic-pathologic correlation one case suggests a combination of microvascular hemorrhagic and ischemic that may reflect an underlying hypoxic mechanism injury, which requires validation larger studies. To determine the incidence, distribution, clinical histopathologic correlates Observational, retrospective cohort study: March to May 2020. Single academic medical center. Consecutive (16) admitted intensive care unit...
Rationale: The leading cause of death in coronavirus disease 2019 (COVID-19) is severe pneumonia, with many patients developing acute respiratory distress syndrome (ARDS) and diffuse alveolar damage (DAD). Whether DAD fatal COVID-19 distinct from other causes remains unknown. Objective: To compare lung parenchymal vascular alterations between pneumonia DAD-causing etiologies using a multidimensional approach. Methods: This autopsy cohort consisted consecutive (n = 20) failure histologic 21;...
Background: Neurofibrillary tangle (NFT) accumulation in the entorhinal cortex (EC) precedes transformation from cognitive controls to mild impairment and Alzheimer’s disease (AD). While tauopathy has been described EC before, order degree which individual subfields within are engulfed by NFTs aging preclinical AD stage is unknown. Objective: We aimed investigate substructures map populations of cortical neurons most vulnerable tau pathology stage. Methods: characterized phosphorylated...
Abstract Phosphorylated tau (p‐tau) pathology correlates strongly with cognitive decline and is a pathological hallmark of Alzheimer's Disease (AD). In recent years, phosphorylated transactive response DNA‐binding protein (pTDP‐43) has emerged as common comorbidity, found in up to 70% all AD cases (Josephs et al., Acta Neuropathol, 131(4), 571–585; Josephs, Whitwell, 127(6), 811–824). Current staging schemes for pTDP‐43 primary age‐related tauopathy (PART) track its progression throughout...
Introduction The hippocampus is integral for learning and memory targeted by multiple diseases. Neuroimaging approaches frequently use hippocampal subfield volumes as a standard measure of neurodegeneration, thus making them an essential biomarker to study. Collectively, histologic parcellation studies contain various disagreements, discrepancies, omissions. present study aimed advance the segmentation field establishing first histology based protocol, applied n = 22 human samples. Methods...
Abstract Hippocampal subregions differ in specialization and vulnerability to cell death. Neuron death hippocampal atrophy have been a marker for the progression of Alzheimer’s disease. Relatively few studies examined neuronal loss human brain using stereology. We characterize an automated high-throughput deep learning pipeline segment pyramidal neurons, generate neuron estimates within subfields, relate our results stereology counts. Based on seven cases 168 partitions, we vet parameters...
Neuroimaging studies have routinely used hippocampal volume as a measure of Alzheimer's disease severity, but changes occur too late in the process for potential therapies to be effective. The entorhinal cortex is one first cortical areas affected by disease; its neurons are especially vulnerable neurofibrillary tangles. Entorhinal atrophy also relates conversion from non-clinical clinical disease. In neuroimaging, human has so far mostly been considered entirety or divided into medial and...
Abstract The hippocampal subfield prosubiculum (ProS), is a conserved neuroanatomic region in mouse, monkey, and human. This area lies between CA1 subiculum (Sub) particularly lacks consensus on its boundaries; reports have varied the description of features location. In this report, we review, refine, evaluate four cytoarchitectural that differentiate ProS from neighboring subfields: (1) small neurons, (2) lightly stained (3) superficial clustered (4) cell sparse zone. was delineated all...
The protein sarcospan (SSPN) is an integral member of the dystrophin-glycoprotein complex (DGC) and has been shown to be important in heart during development response acute stress. In this study, we investigated role SSPN cardiac ischemia-reperfusion (IR) injury SSPN-deficient (SSPN-/-) mice. First, hemodynamic SSPN-/- mice was tested similar SSPN+/+ (wild-type) after isoproterenol injection. Using situ Langendorff perfusion method, hearts were subjected IR found have increased infarct size...
Abstract Investigating interindividual variability is a major field of interest in neuroscience. The entorhinal cortex (EC) essential for memory and affected early the progression Alzheimer's disease (AD). We combined histology ground‐truth data with ultrahigh‐resolution 7T ex vivo MRI to analyze EC 3D. Further, we characterized (1) shape as whole, (2) subfield range midpoints, (3) architectural location tau burden derived from 3D probability maps. Our results indicated that varied but was...
Abstract The hippocampus is heterogeneous in its architecture. It contributes to cognitive processes such as memory and spatial navigation susceptible neurodegenerative disease. Cytoarchitectural features neuron size neuronal collinearity have been used parcellate the hippocampal subregions. Moreover, pyramidal orientation (orientation of one individual neuron) (how neurons align) investigated a measure disease schizophrenia. However, comprehensive quantitative study within subregions has...
We describe a 68-year-old man who presented with progressive weakness in proximal muscles of all four limbs and was found to have autoantibody-negative necrotizing autoimmune myopathy (NAM). His refractory corticosteroids methotrexate, but subsequently demonstrated successful response intravenous immunoglobulin (IVIG). The patient also received rituximab, the timing his recovery favored IVIG as more important factor terms efficacy. Treatment guidelines for seronegative myopathies are...
A 64-year-old woman was admitted with a 6-week history of cognitive impairment, headache, and memory loss. She had hyperreflexia impaired attention memory. MRI showed diffuse subarachnoid hyperintensities leptomeningeal enhancement on FLAIR sequences. diagnostic test performed.
Abstract: A 44-year-old woman presented with 2 painful and self-limited episodes of binocular horizontal diplopia within 1 year that at the beginning were thought to be secondary microvascular insult. Her medical history was significant for Cushing syndrome status post transsphenoidal resection bilateral adrenalectomy 4 years prior, hypertension, diabetes mellitus. Neuro-ophthalmic evaluation left abduction deficit incomitant esotropia consistent abducens nerve palsy. Of note, patient had...
A 60-year-old man presented with ongoing fevers and fatigue, a tongue ulcer, dry scaly nodules on the face hands, migratory arthralgias in wrists, fingers, elbows, shoulders. CT revealed dependent reticular opacities throughout lower lobes of lungs. Hypoxemia developed. diagnostic test was performed.
Encephaloceles are neural tube defects characterized by herniation of meninges, tissue and cerebrospinal fluid, while atretic cephaloceles denote a rudimentary connection to the intracranial space with absence herniated represent an infrequent dermatopathologic diagnosis. Limited reports these entities confound challenge in their histopathologic distinction. Accurate classification is important given associated anomalies neurologic manifestations that impact prognosis.We describe...
Abstract The hippocampus is integral for learning and memory targeted by multiple diseases disorders such as anxiety, depression, epilepsy, Alzheimer’s disease. Neuroimaging approaches frequently use hippocampal or subfield volumes a standard measure of neurodegeneration, thus making it an essential biomarker to study. However, in vivo MRI lacks the resolution needed accurately parcellate subfields, histologic delineations rely on vague outdated features. More so, several discrepancies exist...
Globular Glial Tauopathy (GGT) is a rare form of Frontotemporal Lobar Degeneration (FTLD) consisting 4-repeat tau globular inclusions in astrocytes and oligodendrocytes. We present the pathological findings GGT previously published case 73-year-old woman with behavioral symptoms concerning for right temporal variant frontotemporal dementia initial salient features Geschwind syndrome. Clinically, she lacked motor abnormalities otherwise common cases. Brain MRI showed focal anterior atrophy...
Background: Clinical and radiologic studies investigating Coronavirus disease 2019 (COVID-19) indicate that a possible cause of severe hypoxia is marked ventilation-perfusion (VA/Q) mismatch. Published histopathology reports diffuse alveolar damage (DAD) in fatal COVID-19 indistinguishable from other causes DAD. We compared lung parenchymal vascular alterations between DAD etiologies using multidimensional approach.Methods: This autopsy cohort consisted consecutive patients (n=20) with...