A5065049507- Vasculitis and related conditions
- Innovations in Medical Education
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Otitis Media and Relapsing Polychondritis
- Healthcare Systems and Technology
- Diversity and Career in Medicine
- Clinical Reasoning and Diagnostic Skills
- Rheumatoid Arthritis Research and Therapies
- Simulation-Based Education in Healthcare
- Patient-Provider Communication in Healthcare
- Sarcoidosis and Beryllium Toxicity Research
- Inflammatory Myopathies and Dermatomyositis
- Interprofessional Education and Collaboration
- Heparin-Induced Thrombocytopenia and Thrombosis
- Emergency and Acute Care Studies
- Renal Diseases and Glomerulopathies
- IgG4-Related and Inflammatory Diseases
- Patient Satisfaction in Healthcare
- Radiology practices and education
- Systemic Sclerosis and Related Diseases
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Musculoskeletal Disorders and Rehabilitation
- Urticaria and Related Conditions
- Osteoarthritis Treatment and Mechanisms
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Emory University
2021-2024
American College of Rheumatology
2021-2024
Durham VA Medical Center
2021-2024
University of North Carolina at Chapel Hill
2021-2024
Convergence
2024
AID Atlanta
2023-2024
Rheumatology Consultants
2023
eLearning Studios (United Kingdom)
2023
The interleukin-6 pathway is up-regulated in giant cell arteritis (GCA), Takayasu (TA), and polymyalgia rheumatica (PMR). We retrospectively assessed the outcomes of 10 patients with relapsing/refractory GCA, TA, or PMR treated tocilizumab (TCZ).Patients GCA (n = 7), TA 2), 1) received TCZ. Seven subjects had failed at least 1 second-line agent. evaluated were symptoms disease activity, inflammatory markers, ability to taper glucocorticoids, cross-sectional imaging when indicated...
Objective To evaluate whether the classification of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) according to ANCA type (anti-proteinase 3 (PR3) or anti-myeloperoxidase (MPO) antibodies) predicts treatment response. Methods Treatment responses were assessed among enrolled in Rituximab ANCA-associated Vasculitis trial both AAV diagnosis (granulomatosis polyangiitis (GPA)/microscopic (MPA)) and (PR3-AAV/MPO-AAV). Complete remission (CR) was defined as...
To develop a Glucocorticoid Toxicity Index (GTI) to assess glucocorticoid (GC)-related morbidity and GC-sparing ability of other therapies.Nineteen experts on GC use outcome measures from 11 subspecialties participated. Ten were the USA; nine Canada, Europe or Australia. Group consensus methods multicriteria decision analysis (MCDA) used. A Composite GTI Specific List comprise overall GTI. The reflects toxicity likely change during clinical trial. toxicities occur commonly, vary with...
Objective To evaluate the reasons that complete remission is not achieved or maintained with original treatment in some patients antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) treated rituximab (RTX) cyclophosphamide/azathioprine (CYC/AZA). Methods The Rituximab AAV trial was a randomized, double‐blind, placebo‐controlled comparing rate of induction among RTX (n = 99) and CYC followed by AZA 98). Glucocorticoids were tapered over period 5 months. primary outcome...
Objective To examine the relationship of antineutrophil cytoplasmic antibody (ANCA) type and ANCA‐associated vasculitis (AAV) diagnosis with demographic features, disease manifestations, clinical outcomes. We focused on patients who account for differences between ANCA classifications: anti‐myeloperoxidase (MPO)–ANCA–positive ANCA‐negative granulomatosis polyangiitis (Wegener's) (GPA). Methods performed a pooled analysis Wegener's Granulomatosis Etanercept Trial Rituximab in ANCA‐Associated...
Disease relapses are frequent in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). This study was undertaken to evaluate outcomes patients with AAV who re-treated rituximab (RTX) and prednisone for severe disease relapses.
As the U.S. health care system changes and technology alters how doctors work learn, medical schools their faculty are compelled to modify curricula teaching methods. In this article, educational leaders key describe Pathways curriculum was conceived, designed, implemented at Harvard Medical School. Faculty were committed principle that educators should focus on students learn ability apply what they in evaluation of patients. Using best evidence from cognitive sciences about adult learning,...
Methods for assessing residents as teachers are limited, and it can be difficult to discern optimal curricula training educators. A guideline may a tool assess resident-as-teacher programs help enhance culture of teaching learning.We developed consensus academic medical centers' environments.Faculty representing 8 specialties from 5 hospitals created through an iterative expert development process. To local practices, the was administered online survey program directors 47 residency at...
Nonsevere relapses are more common than severe in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), but their clinical course and treatment outcomes remain largely unexamined. We undertook this study to analyze the of patients with nonsevere Rituximab ANCA-Associated Vasculitis (RAVE) trial who were treated prednisone according a prespecified protocol.RAVE was randomized, double-blind, placebo-controlled comparing rituximab (RTX) cyclophosphamide (CYC) followed by...
Objectives The subspecialty consultation represents a potentially powerful opportunity for resident learning, but barriers may limit the educational exchanges between fellows (subspecialty registrars) and residents (house officers). We conducted focus group study of internal medicine (IM) to determine against factors facilitating resident–fellow teaching interactions on wards, identify opportunities maximising learning. Methods four groups IM (n = 18) 16) at two academic medical centres in...
Granulomatosis with polyangiitis (Wegener's) (GPA) is a type of antineutrophil cytoplasmic antibody-associated vasculitis that often entails severe end-organ damage and treatment-related complications frequently lead to hospitalization death. Nationwide trends in hospitalizations in-hospital mortality over the past 2 decades are unknown were evaluated this study.Using National Inpatient Sample, largest all-payer inpatient database US, discharge diagnosis GPA (formerly Wegener's...
Distinct clinical presentations of interstitial lung disease (ILD) with the myositis-specific antibodies, including anti-synthetase are well-recognized. However, association between ILD and myositis-associated anti-Ro52, is less established. Our objectives were to compare presenting phenotypes patients anti-Ro52 alone versus in combination autoantibodies identify predictors progression or death.We performed a retrospective cohort study 73 adults positive antibody. We report features,...
Fellows are expected to educate trainees, peers, and patients, during long after fellowship. However, there has been relatively little emphasis on the acquisition of teaching skills in fellowship programs. Challenges by fellows subspecialty training include demanding clinical duties, their limited knowledge base field, brief contact time with learners consultative roles, and, for new fellows, personal unfamiliarity hospital culture. Fellows' can be improved formal curricula addressing...
CD5+ B cells have been conceptualized as a possible surrogate for Breg cells. The aim of the present study was to determine utility biomarkers in antineutrophil cytoplasmic antibody-associated vasculitis (AAV).The absolute and relative numbers (percentages) (explanatory variables) were measured longitudinally during 18 months 197 patients randomized receive either rituximab (RTX) or cyclophosphamide (CYC) followed by azathioprine (AZA) treatment AAV (Rituximab ANCA-Associated Vasculitis...
ABSTRACT Background Subspecialty consultation in inpatient care is increasing. Teaching by subspecialty fellows a setting may be an important source of work-based learning for students and residents. However, teaching evaluation learners this context challenging due to personal systems-based barriers. Objective We developed evaluated framework designed overcome barriers improve fellow skills during consultation. Methods The PARTNER (Partner with resident, Assess the learner, Reinforce...
Enhancing rheumatology fellows' teaching skills in the setting of inpatient consultation may have a broad positive impact. Such efforts improve clinical and overall patient care. Most importantly, effective resident-fellow interactions not only increase residents' knowledge but influence their career choice. However, number barriers to interaction been identified, including skills. We developed Fellow As Clinical Teacher (FACT) curriculum order enhance during consultation.The FACT was...