Marcy B. Bolster
A5059733222- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Rheumatoid Arthritis Research and Therapies
- Innovations in Medical Education
- Musculoskeletal Disorders and Rehabilitation
- Inflammatory Myopathies and Dermatomyositis
- Bone health and osteoporosis research
- Bone health and treatments
- Pulmonary Hypertension Research and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Lupus Erythematosus Research
- Diversity and Career in Medicine
- Clinical Reasoning and Diagnostic Skills
- Pain Mechanisms and Treatments
- Bone and Joint Diseases
- Dermatologic Treatments and Research
- Bone Metabolism and Diseases
- Spondyloarthritis Studies and Treatments
- Eosinophilic Disorders and Syndromes
- Telemedicine and Telehealth Implementation
- Peripheral Neuropathies and Disorders
- Healthcare Systems and Technology
- Interprofessional Education and Collaboration
- Hip and Femur Fractures
- Connective Tissue Growth Factor Research
Massachusetts General Hospital
2016-2025
Harvard University
2015-2025
Brigham and Women's Hospital
2022
Medical University of South Carolina
2007-2021
ENT and Allergy
2021
North Shore Medical Center
2020
Newton Wellesley Hospital
2020
St. Elizabeth's Medical Center
2020
University of California, Los Angeles
2007-2018
University of Michigan–Ann Arbor
2017-2018
We conducted a double-blind, randomized, placebo-controlled trial to determine the effects of oral cyclophosphamide on lung function and health-related symptoms in patients with evidence active alveolitis scleroderma-related interstitial disease.At 13 clinical centers throughout United States, we enrolled 158 scleroderma, restrictive physiology, dyspnea, inflammatory disease examination bronchoalveolar-lavage fluid, thoracic high-resolution computed tomography, or both. Patients received (<...
The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear. We performed a randomized, double-blind, placebo-controlled trial involving confirmed severe acute respiratory syndrome 2 (SARS-CoV-2) infection, hyperinflammatory states, and at least two the following signs: fever (body temperature >38°C), pulmonary infiltrates, or need for supplemental oxygen order to maintain an...
The Scleroderma Lung Study enrolled 158 patients with scleroderma-related interstitial lung disease in a placebo-controlled trial of oral cyclophosphamide (CYC). Although treatment-related benefits pulmonary function, skin scores, and patient-centered outcomes were demonstrated after 1 year therapy, the duration benefit beyond was unclear.A second follow-up performed to determine if these effects persisted stopping treatment.A detailed analysis data obtained over two years study...
Objective To describe the character and composition of 2015 US adult rheumatology workforce, evaluate workforce trends, project supply demand for clinical care 2015–2030. Methods The Workforce Study Rheumatology Specialists in used primary secondary data sources to estimate baseline determine demographic geographic factors relevant modeling. Supply was projected through 2030, utilizing data‐driven estimations regarding proportion full‐time equivalent ( FTE ) academic versus nonacademic...
We provide evidence-based recommendations regarding the treatment of interstitial lung disease (ILD) in adults with systemic autoimmune rheumatic diseases (SARDs).
Objective We provide evidence‐based recommendations regarding screening for interstitial lung disease (ILD) and the monitoring ILD progression in people with systemic autoimmune rheumatic diseases (SARDs), specifically rheumatoid arthritis, sclerosis, idiopathic inflammatory myopathies, mixed connective tissue disease, Sjögren disease. Methods developed clinically relevant population, intervention, comparator, outcomes questions related to patients SARDs. A systematic literature review was...
Objective We provide evidence‐based recommendations regarding the treatment of interstitial lung disease (ILD) in adults with systemic autoimmune rheumatic diseases (SARDs). Methods developed clinically relevant population, intervention, comparator, and outcomes questions. A systematic literature review was then performed, available evidence rated using Grading Recommendations, Assessment, Development, Evaluation methodology. panel clinicians patients reached consensus on direction strength...
Objective To assess cumulative survival rates and identify independent predictors of mortality in patients with incident systemic sclerosis (SSc)–associated pulmonary arterial hypertension (PAH) who had undergone routine screening for PAH at SSc centers the US. Methods The Pulmonary Hypertension Assessment Recognition Outcomes Scleroderma registry is a prospective high risk or definite diagnosed by right‐sided heart catheterization within 6 months enrollment. Only World Health Organization...
Rationale: The presence of inflammatory cells on bronchoalveolar lavage is often used to predict disease activity and the need for therapy in systemic sclerosis–associated interstitial lung disease.Objectives: To evaluate whether cellularity identifies distinct subsets and/or predicts cyclophosphamide responsiveness.Methods: Patients underwent baseline high-resolution computed tomography as part a randomized placebo-controlled trial versus placebo (Scleroderma Lung Study) determine effect...
To assess the reliability and minimal clinically important differences (MCID) for FVC% predicted in Scleroderma Lung Study I II.
Objective We provide evidence‐based recommendations regarding screening for interstitial lung disease (ILD) and the monitoring ILD progression in people with systemic autoimmune rheumatic diseases (SARDs), specifically rheumatoid arthritis, sclerosis, idiopathic inflammatory myopathies, mixed connective tissue disease, Sjögren disease. Methods developed clinically relevant population, intervention, comparator, outcomes questions related to patients SARDs. A systematic literature review was...
Patients with normal (mean pulmonary arterial pressure (mPAP) ≤20 mm Hg) and borderline mean pressures (21-24 are "at risk" of developing hypertension (PH). The objectives this analysis were to examine the baseline characteristics in systemic sclerosis (SSc) mPAP explore long-term outcomes SSc patients versus haemodynamics.PHAROS is a multicentre prospective longitudinal cohort or recently diagnosed resting PH on right heart catheterisation (RHC). Baseline clinical characteristics, function...
Pain sensitization may contribute to pain severity in rheumatoid arthritis (RA), impacting disease activity assessment. We examined whether processing mechanisms were associated with among RA patients active disease.The study included 139 subjects enrolled the Central Rheumatoid Arthritis cohort. Subjects underwent quantitative sensory testing (QST), including assessment of pressure thresholds (PPTs) at multiple sites, conditioned modulation, and temporal summation. was assessed using...
Given the significant advance of virtual care in past year and half, it seems timely to focus on quality frameworks how they have evolved collaboratively across health organizations. Massachusetts General Hospital's (MGH) Center for TeleHealth Mass Brigham's (MGB) Virtual Care Program are committed hosting annual symposia key topics related care. Subject matter experts country, organizations, academic medical centers invited participate. The inaugural MGH/MGB Symposium, which focused...
Objective Patient engagement is critical to clinical practice guideline (CPG) development. This work presents our approach ascertaining patients’ values and preferences inform the American College of Rheumatology guidelines for screening, monitoring, treatment interstitial lung disease (ILD) in people with systemic autoimmune rheumatic diseases (SARDs). Methods We conducted a cross‐sectional qualitative study purposefully sampled Panel using modified content analytic approach. The team...
Abstract Objective. The pathophysiology of pulmonary fibrosis in patients with systemic sclerosis (SSc) is poorly understood, but a number recent studies have demonstrated an inflammatory process involving the lower respiratory tract. objective present study was to determine concentrations several cytokines bronchoalveolar lavage (BAL) fluid SSc and assess whether enhanced expression certain associated presence alveolitis. Methods. BAL performed on (with or without alveolitis) normal control...
Abstract Objective To assess the impact of cyclophosphamide (CYC) on health‐related quality life (HRQOL) patients with scleroderma after 12 months treatment. Methods One hundred fifty‐eight subjects participated in Scleroderma Lung Study, 79 each randomized to CYC and placebo arms. The study evaluated results 3 measures health status: Short Form 36 (SF‐36), Health Assessment Questionnaire (HAQ) disability index (DI), Mahler's dyspnea index, 1 preference‐based measure, SF‐6D. differences...