M. Sakamoto
A5046560574- Magnetic confinement fusion research
- Fusion materials and technologies
- Superconducting Materials and Applications
- Particle accelerators and beam dynamics
- Ionosphere and magnetosphere dynamics
- Plasma Diagnostics and Applications
- Laser-Plasma Interactions and Diagnostics
- Digital Games and Media
- Innovative Human-Technology Interaction
- Nuclear Materials and Properties
- Solar and Space Plasma Dynamics
- Physics of Superconductivity and Magnetism
- Laser-induced spectroscopy and plasma
- Virtual Reality Applications and Impacts
- Nuclear reactor physics and engineering
- Nuclear Physics and Applications
- Atomic and Molecular Physics
- Gyrotron and Vacuum Electronics Research
- Educational Games and Gamification
- Spacecraft and Cryogenic Technologies
- Atomic and Subatomic Physics Research
- Mobile Crowdsensing and Crowdsourcing
- Augmented Reality Applications
- Persona Design and Applications
- Artificial Intelligence in Games
Japanese Red Cross Nagoya Daiichi Hospital
2025
Kyushu University
2014-2024
University of Tsukuba
2015-2024
Surgical Science (Sweden)
2024
Shibaura Institute of Technology
2022-2024
Kyushu University Hospital
2024
University of Yamanashi
2022-2024
Kyoto University
2021-2023
Plasma (Russia)
2013-2023
Okayama Red Cross General Hospital
2020-2023
Tumor-associated macrophages (TAMs) promote cancer cell proliferation, invasion, and metastasis by producing various mediators. Although preclinical studies demonstrated that TAMs preferentially express CD163 CD204, the TAM subsets in oral squamous carcinoma (OSCC) remain unknown. In this study, we examined expression role of OSCC. Forty-six patients with OSCC were analyzed for biopsy samples immunohistochemistry. We their production immune suppressive molecules (IL-10 PD-L1) peripheral...
Tumor-associated macrophages (TAMs) promote tumor progression and inhibit anti-tumor immune response by producing various mediators preferentially express CD163, CD204, CD206. However, the role of these TAM subsets in oral squamous cell carcinoma (OSCC) remains unclear. Here we investigated expression function OSCC, especially cancer proliferation. Biopsy sample from 44 patients with OSCC were examined for markers EGF immunohistochemistry. production isolated was assessed flow cytometry. We...
As the finalization of a hydrogen experiment towards deuterium phase, exploration best performance plasma was intensively performed in large helical device. High ion and electron temperatures, Ti Te, more than 6 keV were simultaneously achieved by superimposing high-power cyclotron resonance heating onneutral beam injection (NBI) heated plasma. Although flattening temperature profile core region observed during discharges, one could avoid degradation increasing density. Another key parameter...
Zygotic genome activation (ZGA) after fertilization enables the maternal-to-zygotic transition. However, global view of ZGA, particularly at initiation, is incompletely understood. Here, we develop a method to capture and sequence newly synthesized RNA in early mouse embryos, providing transcriptional reprogramming during ZGA. Our data demonstrate that major ZGA gene begins earlier than previously thought. Furthermore, identify set genes activated minor promoters which show enrichment Obox...
IgG4-related disease (IgG4-RD) is a unique inflammatory disorder in which Th2 cytokines promote IgG4 production. In addition, recent studies have implicated the Toll-like receptor (TLR) pathway. This study was undertaken to examine expression of TLRs salivary glands (SGs) from patients with IgG4-RD.SGs 15 IgG4-RD, Sjögren's syndrome (SS), 10 chronic sialadenitis, and healthy controls were examined histologically. TLR family gene (TLR-1 through TLR-10) analyzed by DNA microarray submandibular...
In the first four years of LHD experiment, several encouraging results have emerged, most significant which is that MHD stability and good transport are compatible in inward shifted axis configuration. The observed energy confinement at this optimal configuration consistent with ISS95 scaling an enhancement factor 1.5. over smaller heliotron devices attributed to high edge temperature. We find plasma average beta 3% stable configuration, even though theoretical conditions Mercier modes...
QUEST focuses on the steady state operation of spherical tokamak by controlled PWI and electron Bernstein wave current drive. One main purposes is an achievement long duration discharge with MW-class injected power. As result, should be operated in challenging region heat particle handling. To do handling, high temperature all metal wall up to 623 K closed divertors are planned, which realize steady-state under recycling ratio, R = 1. This a dispensable check DEMO, because pumping avoided as...
Achievement of reactor relevant plasma condition in Helical type magnetic devices and exploration its related physics fusion engineering are the aim Large Device (LHD) project. In recent experiments on LHD, we have achieved ion-temperature 8.1 keV at 1 × 1019 m−3 by optimization wall conditioning using long pulse discharge Ion Cyclotron Heating (ICH). The electron temperature 10 1.6 was also Electron (ECH). For further improvement performance, upgrade (LHD), including deuterium experiment,...
This paper describes the recent progress in divertor simulation research using GAMMA 10/PDX tandem mirror towards development of divertors fusion reactors. During a plasma flow generation experiment end cell 10/PDX, ICRF heating anchor successfully extended particle flux up to 3.3 × 1023 m2 s−1. Superimposing short pulse ECH also attained maximum heat ~30 MW m−2. We have succeeded achieving and characterizing detachment high-temperature plasma, which is equivalent SOL tokamaks, by...
Fully non-inductive second (2nd) harmonic electron cyclotron (EC) plasma current ramp-up was demonstrated with a newlly developed 28 GHz system in the QUEST spherical tokamak. A high of 54 kA non-inductively ramped up and sustained stably for 0.9 s 270 kW wave. higher 66 also achieved slow vertical field. We have significantly than those previously 2nd EC waves. This fully method might be useful future burning devices fusion reactors, particular operations at half magnetic field same heating...
Abstract In recent deuterium experiments on the large helical device (LHD), we succeeded in expanding temperature domain to higher regions for both electron and ion temperatures. Suppression of energetic particle driven resistive interchange mode (EIC) by a moderate increase is key technique extend high LHD plasmas. We found clear isotope effect formation internal transport barrier A new measure hydrogen fraction was developed order investigate behavior mixing state. The revealed that...
[Purpose] To evaluate the validity of measurement sites for assessing blood lactic acid levels following unilateral upper-limb exercises. [Participants and Methods] Blood were measured at fingertips both hands in 40 healthy young men (mean age 20.9 ± 2.5 years). Measurements taken before, immediately after, 90-s intervals exercises involving palmar flexion dorsiflexion non-dominant hand. Exercise load was determined through maximum voluntary contraction testing. [Results] No significant...
The first results of the Dynamic Ergodic Divertor in TEXTOR, when operating m/n=3/1 mode configuration, are presented. deeply penetrating external magnetic field perturbation this configuration increases toroidal plasma rotation. Staying below excitation threshold for m/n=2/1 tearing mode, rotation is always direction current, even if projection rotating opposite direction. observed consistent with a radial electric field, generated by an enhanced electron transport ergodic layers near...
IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition that can affect multiple organs. We previously demonstrated TLR7-transgenic C57BL/6 mice showed elevated serum IgG1 levels and inflammation with fibrosis in the salivary glands (SGs), lungs, pancreas. Moreover, we observed extensive Toll-like receptor 7 (TLR-7)-positive CD163+ M2 macrophage infiltration SGs from IgG4-RD patients. undertook this study to examine fibrotic mechanism via TLR-7 pathway.Gene expression human patients...
Abstract Sjögren’s syndrome is a chronic autoimmune disorder whose pathogenesis poorly understood and that lacks effective therapies. Detailed quantitative spatial analyses of tissues affected by were undertaken, including the quantitation frequency selected cell–cell interactions in disease milieu. Quantitative CD4 + T cell subsets CD8 cells labial salivary glands from untreated patients with primary revealed activated cytotoxic (CD8 CTLs) most prominent these infiltrates. An accumulation...
Experiments aiming at 'day long operation high performance' have been carried out in TRIAM-1M. The record value of the discharge duration was updated to 5 h and 16 min. Steady-state tokamak is studied under localized plasma wall interaction conditions. distributions heat load, particle recycling flux impurity source are investigated understand co-deposition pumping. formation sustainment an internal transport barrier (ITB) enhanced current drive mode has by controlling lower hybrid driven...
KinecDrone enhances our somatic sensation to fly in the sky with Kinect and AR.Drone. A Video stream captured AR.Drone is transmited a user's head mounted display. While user behaves like flying room, he/she can watch scene by Thus, feels that really sky. Also, control his/her natural gestures without losing reality of feeling as if becomes himself/herself. This significantly increases immersive experiences
Abstract Oral lichen planus (OLP) is a chronic inflammatory disease associated with T cell infiltration. The crosstalk between oral epithelium and mucosal cells was considered to be crucial in the pathogenesis of OLP. Here, we selectively extracted normal (NE) lesional (LE) buccal mucosa specimens from three patients OLP by laser capture microdissection due identify pathogenic factors. Cathepsin K (CTSK) identified as one common upregulated genes LE DNA microarray. Immunohistochemically,...
In a circular cross-section plasma bounded by limiter, the H-mode transition is triggered rapid rampdown in current during auxiliary heating, even case when edge electron temperature gradually decreases prior to transition. This result suggests that governed enhancement of magnetic shear near edge, associated with radial modification current-density profile.