A5101679912- IgG4-Related and Inflammatory Diseases
- Salivary Gland Disorders and Functions
- Cancer Treatment and Pharmacology
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Traditional Chinese Medicine Analysis
- Otitis Media and Relapsing Polychondritis
- Psoriasis: Treatment and Pathogenesis
- Oral Health Pathology and Treatment
- Synthetic Organic Chemistry Methods
- Viral gastroenteritis research and epidemiology
- Lymphatic System and Diseases
- Immune Cell Function and Interaction
- Plant-based Medicinal Research
- Transgenic Plants and Applications
- Chemokine receptors and signaling
- Eosinophilic Disorders and Syndromes
- Pain Mechanisms and Treatments
University of Tsukuba
2018-2021
Kyushu University
2014-2020
Kyushu Dental University
2020
IgG4-related disease (IgG4-RD) is a unique inflammatory disorder in which Th2 cytokines promote IgG4 production. In addition, recent studies have implicated the Toll-like receptor (TLR) pathway. This study was undertaken to examine expression of TLRs salivary glands (SGs) from patients with IgG4-RD.SGs 15 IgG4-RD, Sjögren's syndrome (SS), 10 chronic sialadenitis, and healthy controls were examined histologically. TLR family gene (TLR-1 through TLR-10) analyzed by DNA microarray submandibular...
Abstract Oxaliplatin, a chemotherapy medication, causes severe peripheral neuropathy. Although oxaliplatin-induced neuropathy is dose-limiting toxicity, therapeutic strategy against its effects has not been established. We previously reported the involvement of N -methyl-D-aspartate receptors and their intracellular signalling pathway in mechanical allodynia rats. The aim this study was to clarify spinal glutamate transmission allodynia. In vivo microdialysis revealed that baseline...
Abstract Background Our previous studies reveal that CCL18-CCR8 chemokine axis is upregulated in patients of immunoglobulin G4-related disease (IgG4-RD), suggesting the CCL18–CCR8 implicated etiology IgG4-RD, although whether this has a potential as therapeutic target remains unclear. purpose was to clarify pathogenic roles and murine CCL8 (analog human CCL18)–CCR8 by using an animal model IgG4-RD (LAT Y136F knockin mice; LAT mice). Methods We compared infiltration inflammatory cells...
M3 muscarinic acetylcholine receptor (M3R) is one of the autoantigens associated with Sjögren's syndrome (SS) and localized in exocrine glands where disease-specific inflammation occurs. The inflammatory lesion characterized by infiltration CD4+ T cells, including clonally expanded Th17 cells. We undertook this study to identify circulating M3R-specific cells determine functional properties those Using enzyme-linked immunospot assay (ELISpot) method, we identified M3R-reactive peripheral...
Objectives: To determine the protein expression level, expressing cell types, and pathogenic roles of chemokine (C-C motif) ligand 18 (CCL18) its receptor 8 (CCR8) in affected tissues patients with IgG4-related disease (IgG4-RD).Methods: The levels CCL18 labial salivary glands (LSGs) assessed by immunofluorescence (IF) staining were compared among IgG4-RD (n = 3), primary Sjögren's syndrome (pSS; n 4), control subjects 5). macrophages, CD11c+ cells, B plasmacytes LSGs examined double IF...
Journal Article Transgenic rice seeds expressing altered peptide ligands against the M3 muscarinic acetylcholine receptor suppress experimental sialadenitis-like Sjögren's syndrome Get access Hanae Kudo, Kudo Department of Internal Medicine, Faculty University Tsukuba, Ibaraki, Japan; Search for other works by this author on: Oxford Academic Google Scholar Hiroto Tsuboi, Tsuboi Hiromitsu Asashima, Asashima Hiroyuki Takahashi, Takahashi Yuko Ono, Ono Saori Abe, Abe Fumika Honda, Honda Yuya...
Abstract Objective We reported previously that T‐cell‐specific RORγt‐transgenic mice under human CD2 promoter (RORγt‐Tg mice) developed severe spontaneous Sjögren's syndrome (SS)‐like sialadenitis, induced by RORγt‐overexpressing CD4 + T cells and reduced regulatory cells. The purpose of this study was to clarify the effectiveness mechanisms action A213, a RORγt antagonist, in RORγt‐Tg with SS‐like sialadenitis. Methods Six‐week‐old were administered orally A213 or phosphate‐buffered saline...
Oxaliplatin (L‐OHP) is a key drug in the treatment of colorectal cancer, but it causes acute and chronic neuropathies patients. We reported that NMDA receptors spinal cord involved mechanical allodynia induced by L‐OHP (4 mg/kg, i.p., twice week). In this study, we investigated involvement glutamate L‐OHP‐induced more closely. The was reversed not only receptor antagonist MK‐801 also an AMPA NBQX. vivo microdialysis, formalin‐induced nociception (5% formalin, 50µL, s.c.) sustainably...
Abstract Background Our previous studies reveal that CCL18-CCR8 chemokine axis is upregulated in patients of immunoglobulin G4-related disease (IgG4-RD), suggest the CCL18–CCR8 implicated etiology IgG4-RD. Although, whether this has a potential as therapeutic target remains unclear. purpose was to clarify pathogenic roles and murine CCL8 (analogue human CCL18)–CCR8 by using an animal model IgG4-RD (LAT Y136F knockin mice; LAT mice). Methods We compared infiltration inflammatory cells...