A5076446986- Salivary Gland Disorders and Functions
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Immune Cell Function and Interaction
- dental development and anomalies
- Ocular Surface and Contact Lens
- Single-cell and spatial transcriptomics
- Inflammasome and immune disorders
- Diabetes and associated disorders
- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
Kyushu University
2022-2024
Abstract Sjögren’s syndrome is a chronic autoimmune disorder whose pathogenesis poorly understood and that lacks effective therapies. Detailed quantitative spatial analyses of tissues affected by were undertaken, including the quantitation frequency selected cell–cell interactions in disease milieu. Quantitative CD4 + T cell subsets CD8 cells labial salivary glands from untreated patients with primary revealed activated cytotoxic (CD8 CTLs) most prominent these infiltrates. An accumulation...
Cancer immunotherapy targeting CD8+ T cells has made remarkable progress, even for oral squamous cell carcinoma (OSCC), a heterogeneous epithelial tumor without substantial increase in the overall survival rate over past decade. However, therapeutic effects remain limited due to therapy resistance. Thus, more comprehensive understanding of roles CD4+ and B is crucial robust development cancer immunotherapy. In this study, we examined immune responses effector functions cells, infiltrating...
Radiolucent lesions of the mandible, including ameloblastoma, odontogenic keratocyst (OKC), dentigerous cyst (DC) and simple bone (SBC), are frequently encountered in clinical practice. However, they vary type occasionally appearance. Each lesion needs a different treatment approach; therefore, accurate diagnosis is crucial before treatment. radiographic findings, computed tomography (CT), often similar. This study aimed to compare CT findings 41 ameloblastomas, 74 OKCs, 87 DCs, 13 SBCs...
Sjögren's disease (SjD) is an autoimmune marked by lymphocytic infiltration of salivary and lacrimal glands, leading to glandular dysfunction, where CD4-positive helper T (Th) cells their cytokines are crucial in the pathogenesis. Recent studies have demonstrated that Toll-like receptors (TLRs), particularly those recognizing immune complexes containing DNA RNA, contribute Th cell activation various diseases. This study explores expression function these TLRs SjD.
Appropriate differential diagnosis between odontogenic keratocysts (OKCs) and ameloblastomas before treatment is crucial, but the radiographic findings, including computed tomography (CT), are often similar. This study, therefore, aimed to compare CT findings of OKCs in mandible. Forty-one OKC 28 ameloblastoma patients were radiologically evaluated by using initial images focusing on features such as long/short diameters, values, appearance cortex, locularity, scalloped margins, sclerotic...
Abstract Sjögren’s syndrome is a chronic autoimmune disorder whose pathogenesis poorly understood and that lacks effective therapies. Detailed quantitative spatial analyses of tissues affected by were undertaken, including the quantitation frequency selected cell-cell interactions in disease milieu. Quantitative CD4 + T cell subsets CD8 cells labial salivary glands from untreated patients with primary revealed activated cytotoxic (CD8 CTLs) most prominent these infiltrates. An accumulation...