A5060432052- dental development and anomalies
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Hippo pathway signaling and YAP/TAZ
- Neurobiology and Insect Physiology Research
- Oral and Maxillofacial Pathology
- Heat shock proteins research
- Bone and Dental Protein Studies
- Wnt/β-catenin signaling in development and cancer
- Hedgehog Signaling Pathway Studies
- Endodontics and Root Canal Treatments
- Peroxisome Proliferator-Activated Receptors
- DNA and Nucleic Acid Chemistry
- Retinoids in leukemia and cellular processes
- Plant-Microbe Interactions and Immunity
- RNA regulation and disease
- Prostate Cancer Treatment and Research
- RNA Interference and Gene Delivery
- Microbial Inactivation Methods
- Metal complexes synthesis and properties
- Prostate Cancer Diagnosis and Treatment
- Protein Degradation and Inhibitors
- thermodynamics and calorimetric analyses
- Tumors and Oncological Cases
- Renal cell carcinoma treatment
Kyushu University
2016-2025
Åbo Akademi University
2024
University of Turku
2024
Bryan College
2023
Texas A&M University
2017-2023
Kyushu Dental University
2013-2022
Tokyo Women's Medical University
2022
Honda (Japan)
2022
Kyushu Kyoritsu University
2022
Hiroshima University
2017-2021
Abstract Most cancer cells are exposed to altered extracellular environments, such as an increase in matrix (ECM) stiffness and soluble signals consisting of growth factors cytokines. It is therefore conceivable that changes tumor environments affect cell behavior. The Hippo pathway reportedly responds the environment regulates nuclear localization transcription co‐activator, yes‐associated protein (YAP)/transcriptional co‐activator with PDZ‐binding motif (TAZ). Inactivation translocation...
Abstract The lifespan of the tooth is influenced by periodontal ligament (PDL), a specialized connective tissue that connects cementum with socket bone. Generation cell line from PDL progenitor/stem cells would allow development engineering‐based regenerative therapy. However, little known about characteristics because consists heterogeneous population and there are no pure lines. Recently, we succeeded in immortalizing primary human fibroblasts (HPLFs) transfecting them SV40 T‐antigen hTERT...
Abstract Ameloblastoma is an odontogenic neoplasm characterized by slow intraosseous growth with progressive jaw resorption. Recent reports have revealed that ameloblastoma harbours oncogenic BRAF V600E mutation mitogen‐activated protein kinase (MAPK) pathway activation and described cases of harbouring a in which patients were successfully treated inhibitor. Therefore, the MAPK may be involved development ameloblastoma; however, precise mechanism it induces unclear. The expression...
ADP-ribosylation factor-like 4c (ARL4C) is identified as a small GTP-binding protein, which expressed by Wnt and EGF signaling plays an important role in tubulogenesis of cultured cells the ureters. ARL4C little adult tissues, but it highly lung cancer colorectal shown to represent molecular target for therapy based on siRNA experiments. This study revealed that primary hepatocellular carcinoma (HCC) tumors liver metastases, expression associated with poor prognosis these cancers. Chemically...
ADP-ribosylation factor (ARF)-like 4c (ARL4C) expression, induced by a combination of Wnt/β-catenin and EGF/Ras signaling, has been demonstrated to form epithelial morphogenesis. ARL4C overexpression, due signaling alterations, was involved in tumorigenesis. It also reported that expression correlates with DNA hypomethylation the 3'-untranslated region (UTR) gene during lymphogenesis. The current study conducted investigate functions lung tongue cancers. Immunohistochemical analyses tissue...
Growth factor signaling is involved in the development of various organs, but how regulates organ morphogenesis and differentiation a coordinated manner remains to be clarified. Here, we show Wnt controls epithelial morphogenetic changes using salivary gland as model. Experiments genetically manipulated mice cultures revealed that at an early stage (E12-E15) submandibular (SMG) inhibits end bud into proacini by suppressing KIT expression through up-regulation Myb transcription factor,...
ABSTRACT Cellular responses to mechanical stimulation are involved in tissue development and the maintenance of biological functions. Teeth function as receptors for mastication occlusal pressure. During tooth development, germ begins with an invagination epithelium, its morphology matures through dynamic interactions between epithelial cells mesenchymal cells, suggesting that mechanosensors may play important role this process. We analyzed expression Piezo1, a mechanically activated ion...
Male sex drive rhythm (MSDR) in Drosophila is a circadian behavior only observed the social context of male-female pairs. In presence female, males exhibit long periods courtship activity with pronounced rest phase at dusk, although isolated an peak dusk. The molecular mechanisms regulating switch between these patterns are unknown. Here, we genetically manipulate clock different subsets neurons and find that proper oscillation ventral lateral essential for MSDR. These express...
Abstract Odontomas, developmental anomalies of tooth germ, frequently occur in familial adenomatous polyposis patients with activated Wnt/β-catenin signaling. However, roles signaling odontomas or odontogenic cells are unclear. Herein, we investigated β-catenin expression and functions germ development. accumulated nucleus and/or cellular cytoplasm epithelial human odontoma specimens, immunohistochemically. inhibited cell proliferation both line development, while inducing immature bud...