A5031401519- dental development and anomalies
- Oral and Maxillofacial Pathology
- Bone and Dental Protein Studies
- Periodontal Regeneration and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Mesenchymal stem cell research
- Hedgehog Signaling Pathway Studies
- Congenital heart defects research
- Orthopedic Surgery and Rehabilitation
- Peripheral Nerve Disorders
- Anatomy and Medical Technology
- Cleft Lip and Palate Research
- Developmental Biology and Gene Regulation
- Connective tissue disorders research
- Sarcoma Diagnosis and Treatment
- Dental Research and COVID-19
- Elbow and Forearm Trauma Treatment
- Medical and Biological Sciences
- Proteoglycans and glycosaminoglycans research
- Artificial Intelligence in Healthcare and Education
- Fibroblast Growth Factor Research
- Temporomandibular Joint Disorders
- Cell Adhesion Molecules Research
- Congenital Ear and Nasal Anomalies
- Dental Trauma and Treatments
Universidad Complutense de Madrid
2010-2024
Universidad San Pablo CEU
2017
King's College London
2006-2014
Guy's Hospital
2008-2009
University of Southern California
1998-2006
Eastman Dental Hospital
1992
Ameloblastoma is a benign but locally infiltrative odontogenic neoplasm. Although ameloblastomas rarely metastasise, recurrences together with radical surgery often result in facial deformity and significant morbidity. Development of non-invasive therapies has been precluded by lack understanding the molecular background ameloblastoma pathogenesis. When addressing role ERBB receptors as potential new targets for ameloblastoma, we discovered EGFR over-expression clinical samples using...
The aim of the study was to characterize molecular relationship between ameloblastoma and keratocystic odontogenic tumor (KCOT) by means a genome-wide expression analysis. Total RNA from 27 fresh samples 15 solid/multicystic intraosseous ameloblastomas 12 sporadic KCOTs hybridized on Affymetrix whole genome arrays. Hierarchical clustering separated into 2 distinct groups. gene set enrichment analysis based 303 dental genes showed similar separation KCOTs. Early epithelial markers PITX2,...
Abstract Ameloblastoma is an odontogenic neoplasm characterized by slow intraosseous growth with progressive jaw resorption. Recent reports have revealed that ameloblastoma harbours oncogenic BRAF V600E mutation mitogen‐activated protein kinase (MAPK) pathway activation and described cases of harbouring a in which patients were successfully treated inhibitor. Therefore, the MAPK may be involved development ameloblastoma; however, precise mechanism it induces unclear. The expression...
Enamel proteins, particularly amelogenin, have been associated with other functions in addition to regulating enamel biomineralization. Extracts of proteins are currently being used regenerate periodontal tissues, and new studies suggest that might chondrogenic osteogenic properties. In this study, we wanted determine the effect, if any, purified recombinant amelogenin ameloblastin on adhesion, proliferation, differentiation ligament cells vitro. Immortomouse-derived (PDL) were grown under...
Dental pulp stem/progenitor cells guarantee tooth homeostasis, repair and regeneration throughout life. The decision between renewal differentiation of these is influenced by physical molecular interactions with stromal extracellular matrix molecules forming the specialized microenvironment dental stem cell niches. Here we study activation putative niches after injury through upregulation Notch signalling pathway. Notch1, Notch2 Notch3 were used as markers cells. Upon injury, Notch1 are...
Recent advances in molecular and developmental genetics have provided tools for understanding evolutionary changes the nature of epithelial-mesenchymal interactions regulating patterned outgrowth tooth primordia. Tissue recombination experiments mice identified oral epithelium as providing instructive information initiation development. Teeth were lost birds more than 80 million years ago, but despite their disappearance, a number gene products requisite tissue needed formation are found...
Ameloblastomas are locally invasive and aggressive odontogenic tumors treated via surgical resection, which results in facial deformity significant morbidity. Few studies have addressed the cellular molecular events of ameloblastoma onset progression, thus hampering development non-invasive therapeutic approaches. Tumorigenesis is driven by a plethora factors, among innervation has been long neglected. Recent findings shown that directly promotes tumor progression. On this basis, we...
Insulin and insulin-like growth factors (IGF-I IGF-II) are considered pleiotropic, acting as both mitogen differentiation factors. Several investigators have demonstrated the expression of insulin, IGFs, their cognate receptors IGF binding proteins during tooth morphogenesis. Previous work done in our laboratory indicated that exogenous insulin IGFs induce accumulation enamel extracellular matrix on mouse mandibular molars cultured a serumless, chemically defined medium. In order to...
Abstract Insulin‐like growth factors (IGF‐I and IGF‐II) play important roles in regulating differentiation of many different organs including teeth. The presence these the developing tooth has been demonstrated. In vitro studies using explants grown IGFs suggest that they promote ameloblast odontoblasts cells. This is achieved by inducing or repressing gene expression associated with Since some genes involved are expressed both cells, to determine effect IGF on odontoblast cell we first need...
The cleft palate presented by transforming growth factor-β3 <i>(Tgf-β</i><sub><i>3</i></sub><i>)</i> null mutant mice is caused altered palatal shelf adhesion, cell proliferation, epithelial-to-mesenchymal transformation and death. expression of epidermal factor (EGF), factor-β1 <i>(Tgf-β</i><sub><i>1</i></sub><i>)</i> muscle segment homeobox-1 <i>(Msx-1)</i> modified in the palates...
The buccinator muscle derives from the mesenchyme of second pharyngeal arch. In adults, it has a quadrilateral shape, occupying deepest part cheek region. Its function is complex, being active during swallowing, chewing, and sucking. To our knowledge, there are no studies that have specifically analyzed relationship fibers neighboring connective tissue in humans, neither development nor adults. Such relationships fundamental to understand its function. Thus, this study relations with...
To date, there have been no studies conducted on the development of interosseous muscles (IO) in human hand. This study aimed to investigate these order clarify their terminal insertions and relationship with metacarpophalangeal joints.
Positive effects on reducing students' stress have been reported across numerous university settings when anatomy preparatory seminars provided. To date, this type of preparation for coping with cadaver dissection has not studied in Spanish universities. The aim study is to evaluate how first-year medical students face the dissecting room and whether previous about death dying reduces generated. We performed an interventional who received classes before practices (Experimental Group, EG) did...
The juxtaoral organ (JOO) was first described in human embryos by (Chievitz, 1885). In adults, it has been the buccotemporal space—located within soft tissue between medial surface of mandible and buccinator muscle—innervated buccal nerve (Zenker, 1953). Histologically, JOO consists parenchyma formed nests non-keratinizing squamous epithelial cells surrounded two layers or strata connective that form stroma—the stratum fibrosum externum (SE) internum (SI). addition, is rich small branches...