A5062326422- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- dental development and anomalies
- Endodontics and Root Canal Treatments
- Bone Metabolism and Diseases
- Bone and Dental Protein Studies
- Dental Trauma and Treatments
- Tissue Engineering and Regenerative Medicine
- Shape Memory Alloy Transformations
- Bone health and treatments
- Cancer-related gene regulation
- TGF-β signaling in diseases
- Bone Tissue Engineering Materials
- Microstructure and Mechanical Properties of Steels
- Protease and Inhibitor Mechanisms
- Oral microbiology and periodontitis research
- Connective tissue disorders research
- Fibroblast Growth Factor Research
- Nerve injury and regeneration
- Dental materials and restorations
- Pluripotent Stem Cells Research
- Cell Adhesion Molecules Research
- Wnt/β-catenin signaling in development and cancer
- Connective Tissue Growth Factor Research
- NF-κB Signaling Pathways
Kyushu University
2016-2025
Kyushu University Hospital
2015-2024
Kyushu Dental University
2008-2024
Ryukoku University
1995-2022
In-Q-Tel
2014-2016
Psychiatric Rehabilitation Association
1994-2016
Fukuoka University
2012
Osaka University
1990-2012
University of Dental Medicine
2012
American Association of Endodontists
2010
The aim of this study was to explore the effects nutritional manipulations on occurrence and progression age-related pathologic lesions in male Fischer 344 rats. following regimens were studied: (a) ad libitum feeding, (b) food restriction initiated at 6 weeks age, (c) months (d) limited a period early life (6 age), (e) protein without caloric restriction. major observed chronic nephropathy, cardiomyopathy, neoplasia. Food age as effective slowing nephropathy cardiomyopathy delaying much...
Paget's disease is characterized by highly localized areas of increased osteoclast (OCL) activity. This suggests that the microenvironment in pagetic lesions osteoclastogenic, or OCL precursors these are hyperresponsive to osteoclastogenic factors (or both). To examine possibilities, we compared RANK ligand (RANKL) mRNA expression a marrow stromal cell line developed from lesion (PSV10) with normal (Saka), and samples affected bones patients marrow. RANKL was PSV10 cells Saka marrow, also...
Abstract The lifespan of the tooth is influenced by periodontal ligament (PDL), a specialized connective tissue that connects cementum with socket bone. Generation cell line from PDL progenitor/stem cells would allow development engineering‐based regenerative therapy. However, little known about characteristics because consists heterogeneous population and there are no pure lines. Recently, we succeeded in immortalizing primary human fibroblasts (HPLFs) transfecting them SV40 T‐antigen hTERT...
In cases of pulp exposure due to deep dental caries or severe traumatic injuries, existing pulp-capping materials have a limited ability reconstruct dentin-pulp complexes and can result in pulpectomy because their low potentials accelerate cell activities, such as migration, proliferation, differentiation. Therefore, the development more effective therapeutic agents has been anticipated for direct capping. Dental tissues are enriched with stem cells (DPSCs). Here, authors investigated...
Wnt5a, a non-canonical Wnt protein, is known to play important roles in several cell functions. However, little about the effects of Wnt5a on osteoblastic differentiation periodontal ligament (PDL) cells. Here, we examined and associated intracellular signaling human PDL stem/progenitor cells (HPDLSCs). We found that suppressed expression bone-related genes (ALP, BSP, Osterix) alizarin red-positive mineralized nodule formation HPDLSCs under osteogenic conditions. Immunohistochemical analysis...
The periodontal ligament, a highly specialized connective tissue situated between the tooth and alveolar bone of socket, has been thought to influence remodeling bone. effects two human ligament fibroblastic cell populations (HPLFs) on osteoclast‐like (OCL) formation function authentic osteoclasts were examined. addition conditioned media (CM) from both HPLF cultures (HPLF‐CMs) mouse marrow culture inhibited OCL in spite presence 10 −8 m 1 α , 25 dihydroxyvitamin D 3 (1 ,25(OH) 2 ). This...
Atypical Odontalgia (AO) is a condition characterized by tooth pain with no apparent cause. Although psychiatric comorbidity seems to be very common, it has rarely been studied. To clarify the influence of on clinical features in patients AO, we retrospectively evaluated their examination records.Clinical and diagnoses 383 AO were investigated reviewing patients' medical records referral letters. Psychiatric categorized according Diagnostic Statistical Manual Mental Disorders, Fifth Edition...
Repair of injured peripheral nerve is thought to play important roles in tissue homeostasis and regeneration. Recent experiments have demonstrated enhanced functional recovery damaged neurons by some types somatic stem cells. It remains unclear, however, if periodontal ligament (PDL) cells possess such functions. We recently developed a multipotent clonal human PDL cell line, termed line 1-17. Here, we investigated the effects this on neurocytic differentiation, migration, survival. This...
Abstract Aim To characterize the microbial composition of persistent periapical lesions root filled teeth using a molecular genetics approach. Methodology Apical lesion samples were collected from 12 patients (23–80 years old) who visited Kyushu University Hospital for apicectomy with associated teeth. DNA was directly extracted each sample and comprehensively analysed clone library analysis 16S r RNA gene. Enterococcus faecalis , Candida albicans specific fimA genotypes Porphyromonas...