A5087249161- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Fatty Acid Research and Health
- Nutritional Studies and Diet
- Dental Anxiety and Anesthesia Techniques
- Diet, Metabolism, and Disease
- Temporomandibular Joint Disorders
- Trigeminal Neuralgia and Treatments
- Eicosanoids and Hypertension Pharmacology
- Musculoskeletal pain and rehabilitation
- Neuroscience and Neuropharmacology Research
- Dental Erosion and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Salivary Gland Disorders and Functions
- Autoimmune Neurological Disorders and Treatments
- Nutrition, Genetics, and Disease
- Pharmaceutical studies and practices
- Liver Disease Diagnosis and Treatment
- Restraint-Related Deaths
- Liver Diseases and Immunity
- Stress Responses and Cortisol
- Cancer Risks and Factors
- Migraine and Headache Studies
- Birth, Development, and Health
- Liver Disease and Transplantation
Nihon University
2017-2024
Sendai Shirayuri Women's College
2016-2024
Honda (Japan)
2018-2024
Tokyo Medical and Dental University
2017-2020
Nara Women's University
2009-2018
Niigata University
2016
To examine predictive factors for abdominal obesity or metabolic syndrome, we investigated the association of plasma fatty acid composition, estimated desaturase activity, and nutrient intakes, with syndrome in Japanese males. Clinical characteristics, composition cholesteryl esters, energy intakes were analyzed 3 groups: (MS, n=24), (OB, n=43), control (n=27). The activities calculated by ratio 16:1n-7/16:0, 18:3n-6/18:2n-6, 20:4n-6/20:3n-6 esters as surrogates measure delta 9, 6, 5...
Atypical Odontalgia (AO) is a condition characterized by tooth pain with no apparent cause. Although psychiatric comorbidity seems to be very common, it has rarely been studied. To clarify the influence of on clinical features in patients AO, we retrospectively evaluated their examination records.Clinical and diagnoses 383 AO were investigated reviewing patients' medical records referral letters. Psychiatric categorized according Diagnostic Statistical Manual Mental Disorders, Fifth Edition...
Abstract Iatrogenic trigeminal nerve injuries remain a common and complex clinical problem. Satellite glial cell ( SGC ) activation, associated phosphorylation of extracellular signal‐regulated kinase ERK ), neuropeptide expression in the ganglion TG are known to be involved neuropathic pain related injury. However, involvement these molecules orofacial mechanisms is still unknown. Phosphorylation 1/2 lingual crush LNC rats was observed s. To evaluate role neuron– interactions under pain,...
Insulin-like growth factor-1 (IGF-1) is upregulated in the injured peripheral nerve bundle and controls nociceptive neuronal excitability associated with injury. Here, we examined involvement of IGF-1 signaling orofacial neuropathic pain following infraorbital injury (IONI) rats. IONI promoted macrophage accumulation ION, as well ipsilateral trigeminal ganglion (TG), induced mechanical allodynia whisker pad skin together enhancement activities subnucleus caudalis spinal nucleus upper...
The P2Y 12 receptor expressed in satellite cells of the trigeminal ganglion is thought to contribute neuropathic pain. functional interaction between neurons and via receptors phosphorylated extracellular signal‐regulated kinase 1/2 ( pERK 1/2) underlying pain tongue was evaluated this study. Expression enhanced 1/2‐immunoreactive encircling after lingual nerve crush. administration crush rats a selective antagonist, MRS 2395, attenuated hypersensitivity mechanical heat stimulation...
Oral cenesthopathy is characterized by foreign body sensations without medical and dental evidence for them. It thought to be a rare disease in psychiatry, but many patients are visiting clinics seeking treatment remove body. Even though the features of oral might different between psychiatric clinic clinic, there has been no clinic-statistical study from dentists. In this study, we report clinico-statistical with dentistry.This retrospective chart review 606 outpatients Tokyo Medical Dental...
Dietary fat is an important determinant in the development and progression of high blood pressure (BP), a major risk factor for cardiovascular diseases mortality. The aim present study was to determine association between plasma phospholipid fatty acids hypertension Japanese men. level linoleic acid (LA) subjects with (systolic BP ≥140 mmHg and/or diastolic ≥90 mmHg) identified be significantly higher than that healthy controls. Following adjustment age, body mass index, physical activity,...
Atypical odontalgia (AO) is a disease characterized by continuous pain affecting the teeth or tooth sockets after extraction in absence of any identifiable cause on clinical radiographic examination. Antidepressants, such as amitriptyline, are reported to be effective treatment AO; however, their efficacy varies depending case. In this article, we report three types AO and discuss its heterogeneity management. first case, 58-year-old woman presented with heavy, splitting four maxillary front...
We evaluated the mechanisms underlying spinal cord stimulation (SCS)-induced analgesic effect on neuropathic pain following spared nerve injury (SNI). On day 3 after SNI, SCS was performed for 6 h by using electrodes paraspinally placed L4-S1 cord. The effects of and intraperitoneal minocycline administration plantar mechanical sensitivity, microglial activation, neuronal excitability in L4 dorsal horn were assessed SNI. somatosensory cortical responses to electrical hind paw SNI examined...
Cytokeratin (CK) 18 M30 antigen has been proposed as a diagnostic marker of nonalcoholic fatty liver disease (NAFLD). We studied serum CK18 level and examined the correlations among biological data, dietary intake, plasma acid composition in middle-aged Japanese males with (NAFLD; n=42) without NAFLD (control; n=35). was diagnosed if subjects showed on abdominal ultrasonography their alcohol consumption <20 g/d. They were also confirmed to have negative serological results for tests...
Abstract Objective This study aimed (1) to investigate the differences in clinical characteristics of patients between 2 groups, those who have atypical odontalgia ( AO ) only and with burning mouth syndrome BMS ), (2) assess influence psychiatric comorbidity factors on patients' experiences. Method Medical records referral forms visiting Psychosomatic Dentistry Clinic Tokyo Dental University 2013 2016 were reviewed. The final sample included groups 355 patients: n = 272) ‐ ; 83)....
Persistent idiopathic facial pain (PIFP) is the unexplained along territory of trigeminal nerve, including nonorganic tooth called atypical odontalgia (AO). Though PIFP debilitating to patients' livelihood and well-being, its pathophysiology remains poorly understood. Although neurovascular compression (NVC) nerve known be associated with neuralgia (TN), relationship between NVC other orofacial pains has not been fully elucidated.In this study, we investigated differences in characteristics...
There has been considerable research which focused on clarifying the origin of pain in patients with atypical odontalgia (AO), also known as "idiopathic toothache", and identifying effective treatment, but there limited success so far. In this study, we assessed outcomes treatment attempted to identify factors that could account for remission AO.
Background: The Tohoku Medical Megabank Project (TMM) was established to realize personalized healthcare and medicine using genomic omics data. This study evaluated the validity reproducibility of food group intakes derived from a self-administered frequency questionnaire (TMM-FFQ) that included response option "constitutionally unable eat/drink it" among community-dwelling Japanese adults.
Abstract Background Phantom bite syndrome (PBS) is characterised by occlusal discomfort without corresponding dental abnormalities. Despite repeated, failed treatments, patients with PBS persist in seeking correction. has been regarded as a mental disorder. However, we have reported that trigger tend to less psychiatric history than those without. Hence, the symptoms of cannot be explained disorder alone, and it unclear if disorders affect sensation. Objective To elucidate pathophysiology...
: The mechanical head-withdrawal threshold (MHWT) was significantly reduced following inferior alveolar nerve transection (IANX) in rats. Nitrate and nitrite synthesis dramatically increased the trigeminal ganglion (TG) at 6 h after IANX. relative number of neuronal nitric oxide synthase (nNOS)-immunoreactive (IR) cells higher IANX rats compared to sham-operated N-propyl-L-arginine (NPLA)-treated On day 3 NPLA administration, MHWT recovered considerably Following L-arginine injection into...
Phantom bite syndrome (PBS) is characterized by an uncomfortable sensation during occlusion without any evident abnormality. A recent case-control study with single-photon emission computed tomography (SPECT) using 99mTc-ethyl cysteinate dimer could not find the specific features of regional cerebral blood flow (rCBF), which might be due to heterogeneity PBS. We analyzed brain images PBS corresponding clinical studying subgroups.This contributes elucidating pathophysiology evaluating...
Recently, web-based dietary assessment tools for the targeted population have been developed and used to estimate intake level in several epidemiological studies. This study aimed examine validity of estimating energy nutrient by 24 h recall (Web24HR), which we Japanese population. Overall, 228 adults aged ≥20 years who agreed participate were included. Web24HR was administered three times per person: twice within 3 weeks once months later. The data on 3-day weighed food records (WFR) at...
The Tohoku Medical Megabank Project has initiated the Birth and Three-Generation Cohort Study (TMM BirThree Study) including genomic omics investigations, conducted a self-administered food frequency questionnaire with response option "constitutionally unable to eat or drink it" for individual items (TMM-FFQ) pregnant women. This study evaluated validity of TMM-FFQ among
Bright light stimulation of the eye activates trigeminal subnucleus caudalis (Vc) neurons in rats. Sensory information is conveyed to Vc via ganglion (TG). Thus, it likely that TG respond photic and are involved hypersensitivity. However, mechanisms underlying this process unclear. Therefore, hypothesis study bright enhances excitability Expressions calcitonin gene-related peptide (CGRP) neuronal nitric oxide synthase (nNOS) were significantly higher from 5 min 12 h after eye....
To establish a new rat model of craniofacial myalgia, and to clarify which central nervous system pathways are activated in the model.Craniofacial represented by myogenous temporomandibular disorder tension-type headache with pericranial tenderness, is more common female patients. The pain thought be type multifactorial several coexisting causes. our knowledge, there no models muscle hyperalgesia caused multiple types stimuli.We injected nerve growth factor into trapezius male rats...