A5051058636- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Chronic Kidney Disease and Diabetes
- Potassium and Related Disorders
- Dialysis and Renal Disease Management
- Innovations in Medical Education
- Renal Diseases and Glomerulopathies
- Acute Kidney Injury Research
- Problem and Project Based Learning
- Ion Transport and Channel Regulation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Clinical Reasoning and Diagnostic Skills
- Renal Transplantation Outcomes and Treatments
- Diet and metabolism studies
- Renal and Vascular Pathologies
- Muscle and Compartmental Disorders
- Urinary Tract Infections Management
- Empathy and Medical Education
- Organ Donation and Transplantation
- Hormonal Regulation and Hypertension
- Pregnancy and Medication Impact
- Organ Transplantation Techniques and Outcomes
- Extracellular vesicles in disease
- Evaluation of Teaching Practices
- Academic Publishing and Open Access
Harvard University
2015-2025
Beth Israel Deaconess Medical Center
2016-2025
Massachusetts General Hospital
2022
Jupiter Medical Center
2022
University of Pennsylvania
2021
Potassium disorders are common in patients with kidney disease, particularly tubular and low glomerular filtration rate. A multidisciplinary group of researchers clinicians met October 2018 to identify evidence address controversies potassium management. The issues discussed encompassed our latest understanding the regulation excretion health disease; relationship intake cardiovascular outcomes, increasing showing beneficial associations plant-based diet data suggest a paradigm shift from...
The proximal tubule of the kidney plays a crucial role in renal handling drugs (e.g., diuretics), uremic toxins indoxyl sulfate), environmental mercury, aristolochic acid), metabolites uric dietary compounds, and signaling molecules. This process is dependent on many multispecific transporters solute carrier (SLC) superfamily, including organic anion transporter (OAT) cation (OCT) subfamilies, ATP-binding cassette (ABC) superfamily. We review basic physiology these SLC ABC transporters,...
As the U.S. health care system changes and technology alters how doctors work learn, medical schools their faculty are compelled to modify curricula teaching methods. In this article, educational leaders key describe Pathways curriculum was conceived, designed, implemented at Harvard Medical School. Faculty were committed principle that educators should focus on students learn ability apply what they in evaluation of patients. Using best evidence from cognitive sciences about adult learning,...
Abstract Background Kidney disease (KD) is an important health equity issue with Black, Hispanic, and socioeconomically disadvantaged individuals experiencing a disproportionate burden. Prior to 2021, the commonly used estimated glomerular filtration rate (eGFR) equations incorporated coefficients for Black race that conferred higher GFR estimates compared non-Black of same sex, age, blood creatinine concentration. With recognition does not delineate distinct biological categories, joint...
Abstract Background Acute kidney injury (AKI) is a sudden episode of damage or failure affecting up to 15% hospitalized patients and associated with serious short- long-term complications, mortality, health care costs. Current practices diagnose stage AKI are variable do not factor in our improved understanding the biological analytical variability creatinine. In addition, emergence biomarkers, for example, cystatin C, insulin-like growth binding protein 7, tissue inhibitor...
Large group collaborative teaching approaches are rapidly gaining popularity in undergraduate medical education. The case-based Learning (CBCL) pedagogy was instituted for pre-clerkship at Harvard Medical School 2015 with subsequent implementation other schools. CBCL emphasizes inductive reasoning, integrates basic and clinical sciences, stimulates curiosity, fosters teamwork. Given the ongoing educational evolution, guidance on designing facilitating learning sessions, such as may benefit...
BackgroundWeb-based formative assessment tools have become widely recognized in medical education as valuable resources for self-directed learning.ObjectivesTo explore the educational value of using online quizzes kidney pathology learning our renal pathophysiology course.MethodsStudents were given unrestricted and optional access to quizzes. Performance on quizzed non-quizzed materials those who used ('quizzers') did not use tool ('non-quizzers') was compared. Frequency usage analyzed...
<h3>Importance</h3> Urine sediment microscopy is commonly performed during the evaluation of kidney disease. Interobserver reliability nephrologists' urine examination has not been well studied. <h3>Objective</h3> Assess interobserver examination. <h3>Design, Setting, and Participants</h3> In this diagnostic test study, samples were prospectively collected from a convenience sample adult patients an academic hospital in United States undergoing biopsy July 11, 2018, to March 20, 2019....
Race is a social construct that cannot be measured, can used imprecisely and may contribute to disparities in kidney transplant access for Black patients. At Beth Israel Deaconess Medical Center, we dropped the race coefficient estimated glomerular filtration rate (eGFR) report 2017. We conducted quality improvement project examine impact of this change. Before change, only 26% our patients were listed preemptive compared 70% White Since found steady increase percentage before starting...
Summary Nephrology ranks next to last in career choices among US medical school graduates. The American Society of established a Workforce Committee help address this issue. Surveys students indicate that experiences during kidney pathophysiology courses the preclerkship years may impact their decision consider nephrology. In October 2011, preclinical physiology and course directors at schools were surveyed about teaching methods, curricular content, resources, institutional support for...
Coinfection with hepatitis C (HCV) significantly increases the risk of acute and chronic renal disease in HIV-infected individuals. However, burden kidney injury (AKI) directly attributable to HIV among HCV-infected individuals associated factors are not well understood. Within a prospective cohort, AKI episodes were identified by rise creatinine 0.5 mg/dL. Incidence first events was calculated for HIV/HCV coinfected versus HCV monoinfected subjects, multivariable analyses using Cox...
This case report describes the evaluation of a 52-year-old woman taking thiazide diuretic with hypokalemia (potassium, 2.6 mEq/L) and hypertension (blood pressure, 159/94 mm Hg) presents an algorithm for diagnosis management underlying causes low serum potassium levels.
Abstract Background 17q12 deletion syndrome encompasses a broad constellation of clinical phenotypes, including renal magnesium wasting, maturity-onset diabetes the young (MODY), cysts, genitourinary malformations, and neuropsychiatric illness. Manifestations outside renal, endocrine, nervous systems have not been well described. Case presentation We report 62-year-old male referred to Undiagnosed Diseases Program (UDP) at National Institutes Health (NIH) who presented with persistent...
Introduction With this issue, CJASN begins a new series of review articles designed to reconnect clinical nephrologists and trainees with the fundamentals renal physiology pathophysiology. For many us, our initial interest in nephrology was result fascination fluid electrolyte disturbances intricate underlying pathophysiologic mechanisms. However, modern practice training, several factors reduce familiarity practitioners fellows that initially piqued their interest. Increasingly,...
Diet-related chronic diseases are increasing in prevalence and poised to dominate the future careers of current medical students. While value nutritionally-informed care nutrition-based health interventions is increasingly recognized, nutrition education inconsistently often inadequately included school curricula. One obstacle incorporating into dental curricula density existing coursework, with incorporation new material necessitating removal other material. solution engage students outside...