A5055767226- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Nutritional Studies and Diet
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Nutrition, Genetics, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Cardiovascular Function and Risk Factors
- Pregnancy and preeclampsia studies
- Muscle metabolism and nutrition
- Esophageal Cancer Research and Treatment
- Digestive system and related health
- Lipoproteins and Cardiovascular Health
- Diabetes Management and Research
- Sirtuins and Resveratrol in Medicine
- Parkinson's Disease Mechanisms and Treatments
- Eating Disorders and Behaviors
- Folate and B Vitamins Research
- Adipose Tissue and Metabolism
- Alcoholism and Thiamine Deficiency
- Nuclear Receptors and Signaling
- Biochemical Acid Research Studies
- Reproductive System and Pregnancy
Harvard University
2019-2025
Massachusetts General Hospital
2022-2023
Beth Israel Deaconess Medical Center
2022
Jupiter Medical Center
2022
University of Oxford
2019-2021
Yale University
2014-2018
Very-low-carbohydrate diets, including ketogenic and carnivore are gaining popularity for the experimental treatment of a wide range disorders, inflammatory bowel disease (IBD).
Changes in low-density lipoprotein cholesterol (LDL-C) among people following a ketogenic diet (KD) are heterogeneous. Prior work has identified an inverse association between body mass index and change LDL-C. However, the cardiovascular disease risk implications of these lipid changes remain unknown. The aim study was to examine plaque progression its predicting factors. One hundred individuals exhibiting KD-induced LDL-C ≥190 mg/dL, high-density ≥60 triglycerides ≤80 mg/dL were followed...
BACKGROUND Increases in low-density lipoprotein cholesterol (LDL-C) can occur on carbohydrate restricted ketogenic diets.Lean metabolically healthy individuals with a low triglyceride-to-high-density ratio appear particularly susceptible, giving rise to the novel "lean mass hyper-responder" (LMHR) phenotype.OBJECTIVES The purpose of study was assess coronary plaque burden LMHR and near-LMHR LDL-C $190 mg/dL (ketogenic diet [KETO]) compared matched controls lower from Miami Heart (MiHeart)...
People commencing a carbohydrate-restricted diet (CRD) experience markedly heterogenous responses in LDL cholesterol, ranging from extreme elevations to reductions.
Despite the overwhelming prevalence of anxiety disorders in modern society, medications and psychotherapy often fail to achieve complete symptom resolution. A complementary approach medicating symptoms is address underlying metabolic pathologies associated with mental illnesses anxiety. This may be achieved through nutritional interventions. In this perspectives piece, we highlight roles microbiome inflammation as influencers We further discuss evidence base for six specific interventions:...
When lean people adopt carbohydrate-restricted diets (CRDs), they may develop a lipid profile consisting of elevated LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) with low triglycerides (TGs). The magnitude this correlates BMI such that those lower exhibit larger increases in both LDL-C HDL-C. inverse association between HDL-C change on CRD contributed to the discovery subset individuals-termed Lean Mass Hyper-Responders (LMHR)-who, despite normal pre-diet LDL-C, as compared non-LMHR...
The global rise in type 2 diabetes (T2D) and obesity necessitates innovative dietary interventions. This study investigates the effects of allulose, a rare sugar shown to reduce blood glucose, rat model diet-induced T2D. Over 12 weeks, we hypothesized that allulose supplementation would improve body weight, insulin sensitivity, glycemic control. Our results showed mitigated adverse high-fat, high-sugar diets, including reduced weight gain improved resistance. group exhibited lower food...
As the prevalence of Alzheimer disease (AD) continues to rise unabated, new models have been put forth improve our understanding this devastating condition. Although individual may their merits, integrated prove more valuable. Indeed, reliable failures monotherapies for AD, and ensuing surrender major drug companies, suggests that an perspective be necessary if we are invent multifaceted treatments could ultimately successful. In review article, discuss Wnt/Glycogen Synthase Kinase 3β...
Abstract Background Interventions that induce ketosis simultaneously lower blood glucose and the explanation for this phenomenon is unknown. Additionally, glucose‐lowering effect of acute greater in people with type 2 diabetes (T2D). On contrary, L‐alanine a gluconeogenic substrate secreted by skeletal muscle at higher levels T2D infusing ketones circulating levels. In study, we sought to determine whether supplementation would attenuate exogenous using ketone ester (KE). Methods This...
Abstract Introduction Ketogenic diets have shown to improve glycaemic control in patients with type 2 diabetes. This study investigated the safety, tolerability, and effects on diabetes of an exogenous ketone monoester (KE) capable inducing fasting‐like elevations serum β‐hydroxybutyrate (βHB) without need for caloric or carbohydrate restriction. Methods Twenty one participants (14 men 7 women, aged 45 ± 11 years) insulin‐independent diabetes, unchanged hypoglycaemic medication previous 6...
Recent research has identified a unique population of ‘Lean Mass Hyper-Responders’ (LMHR) who exhibit increases in LDL cholesterol (LDL-C) response to carbohydrate-restricted diets levels ≥ 200 mg/dL, association with HDL 80 mg/dL and triglycerides ≤ 70 mg/dL. This triad markers occurs primarily lean metabolically healthy subjects, the magnitude increase LDL-C inversely associated body mass index. The lipid energy model been proposed as one explanation for LMHR phenotype posits that there is...
Background Cost, scalability, and durability represent major challenges to the implementation of intensive lifestyle treatments for obesity diabetes. We previously reported pilot data from a 6-month intervention in which self-insured manufacturing company partnered with metabolic health clinic that utilizes therapeutic carbohydrate reduction (TCR), asynchronous monitoring, community-based approach treat employees disease. This manuscript presents weight loss cost-savings deprescription at...
Chromosome segregation errors in human oocytes increase dramatically as women age and premature loss of meiotic cohesion is one factor that contributes to a higher incidence older oocytes. Here we show maintenance during prophase Drosophila requires the NAD + -dependent deacetylase, Sirt1. Knockdown Sirt1 causes arm chromosome errors. We have previously demonstrated when arrest diplotene, significantly. By quantifying acetylation substrate H4K16 on chromosomes, find deacetylase activity...
Preeclampsia (PE) is an idiopathic multisystem disease affecting 5–7% of pregnant women. Placental oxidative stress a characteristic feature PE and occurs when the production reactive oxygen species (ROS) within placenta overwhelms intrinsic anti-oxidant defenses. We hypothesize that excessive DNA damage at fetal-maternal interface coupled with defective damage/repair response causally related to PE. Here we demonstrate γH2AX (a sensitive marker damage) expressed in maternal decidua but not...
Routine exercise is thought to be among the only disease-modifying treatments for Parkinson's disease; however, patients' progressive loss of physical ability limits its application. Therefore, we sought investigate whether a ketone ester drink, which has previously been shown enhance endurance performance in elite athletes, could also improve persons with disease.14 patients, aged 40-80 years, Hoehn and Yahr stage 1-2 disease.A randomized, placebo-controlled, crossover study each...
High-fat, low-carbohydrate ketogenic diets have recently become popular for weight loss as well the treatment of numerous chronic diseases; however, general medical community still expresses concern regarding impact high-fat on serum lipids and cardiovascular risk. Herein we report young man who adopted a diet to effectively treat his inflammatory bowel disease. Incidentally, changes in were noted which would be considered adverse by current standards. A more critical analysis lipid profile...
Background: Anorexia nervosa is a devastating condition that increases risk of death over five-fold and associated with high rate relapse. Considering the growing field metabolic psychiatry, anorexia can be framed as ‘metabolic-psychiatric’ may benefit from treatment health interventions neuromodulatory properties. Ketogenic diets, very low carbohydrate high-fat are one such intervention long history use in epilepsy more recently other systemic, neurological mental conditions.Aim: To...