A5038762107- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Posttraumatic Stress Disorder Research
- Diet and metabolism studies
- Lipoproteins and Cardiovascular Health
- Anesthesia and Neurotoxicity Research
- Neuroendocrine regulation and behavior
- Traumatic Brain Injury Research
- Neural dynamics and brain function
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Health Systems, Economic Evaluations, Quality of Life
- Diet, Metabolism, and Disease
- Neurogenesis and neuroplasticity mechanisms
- Resilience and Mental Health
- Computational Drug Discovery Methods
- Metabolism, Diabetes, and Cancer
- Cholinesterase and Neurodegenerative Diseases
- Neural Networks and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Music Perception
University of South Florida
2015-2024
University of Illinois Urbana-Champaign
2021
Yellowstone Ecological Research Center
2020
James A. Haley Veterans' Hospital
2000-2016
United States Department of Veterans Affairs
1989-2015
Westchester Medical Center
2014
New York Medical College
2014
Rehabilitation Research and Development Service
2012-2013
AdventHealth Tampa
2003-2013
Center for Clinical Research (United States)
2013
Studies have shown that peripheral levels of corticosterone correlate with the magnitudes two well-described physiological models memory, long-term potentiation (LTP) and primed burst (PB) potentiation. In present experiments, authors investigated effects experimenter-controlled manipulations on magnitude hippocampal PB in urethane-anesthetized rats. Primed is a long-lasting (at least 30 minutes) increase amplitude CA1 population spike EPSP slope response to physiologically patterned...
This series of studies investigated the effects predator exposure on working memory in rats trained radial arm water maze (RAWM). The RAWM is a modified Morris that contains four or six swim paths (arms) radiating out an open central area, with hidden platform located at end one arms. was same each trial within day and different across days. Each learned location during acquisition trials, then were removed from for 30-min delay period. During period, placed either their home cage (nonstress...
Previously, we showed that blueberry (BB) supplementation reversed the deleterious effects of aging on motor behavior and neuronal signaling in senescent rodents. We now report BB-fed (from 4 months age) APP + PS1 transgenic mice no deficits Y-maze performance (at 12 with alterations amyloid beta burden. It appeared protective mechanisms are derived from BB-induced enhancement memory-associated (e.g. extracellular signal-regulated kinase) neutral sphingomyelin-specific phospholipase C...
Stress blocks hippocampal primed-burst potentiation, a low threshold form of long-term thereby suggesting that stress should also impair hippocampal-dependent memory. Therefore, the effects on working (hippocampal-dependent) and reference (hippocampal-independent) memory were evaluated. Rats foraged for food in seven arms 14-arm radial maze. After they ate four baited arms, placed an unfamiliar environment (stress) 4-hr delay. At end delay returned to maze locate 3 remaining arms. impaired...
This study evaluated the effects of acute psychological stress (cat exposure) in adult male rats on electrophysiological plasticity subsequently assessed hippocampus vitro. Two physiological models memory were studied CA1 each recording session: (1) primed burst potentiation (PBP), a low-threshold form produced by total five physiologically patterned pulses; and (2) long-term (LTP), suprathreshold train 100 pulses. Three groups studied: undisturbed their home cage (home cage); placed chamber...
We have studied the influence of predator stress (30 min cat exposure) on long-term (24 h) spatial memory and density spines in basilar dendrites CA1 neurons. Predator occurred either immediately before water maze training (Stress Pre-Training) or 24 h test Pre-Retrieval). The Control (nonstress) group exhibited excellent a robust increase stubby, but not mushroom, shaped spines. Stress Pre-Training had impaired did exhibit any changes spine density. Pre-Retrieval was also performance, this...
The long-term consequences of traumatic brain injury (TBI), specifically the detrimental effects inflammation on neurogenic niches, are not very well understood. In present in vivo study, we examined prolonged pathological outcomes experimental TBI different parts rat with special emphasis and neurogenesis. Sixty days after moderate controlled cortical impact injury, adult Sprague-Dawley male rats were euthanized tissues harvested. Antibodies against activated microglial marker, OX6, cell...
We have studied the effects of an acute predator stress experience on spatial learning and memory in adult male female Sprague-Dawley rats. All rats were trained to learn location a hidden escape platform radial-arm water maze (RAWM), hippocampus-dependent task. In control (non-stress) condition, superior males accuracy consistency their performance tested over multiple days training. exposed cat for 30 min immediately before or after learning, 24-h test. Predator dramatically increased...
High concentrations of pituitary adenylate cyclase-activating polypeptide (PACAP) nerve fibers are present in the central nucleus amygdala (CeA), a brain region implicated control fear-related behavior. This study evaluated PACAPergic modulation fear responses at CeA male Sprague-Dawley rats. PACAP (50–100 pmol) microinfusion via intra-CeA cannulae produced increases immobility and time rats spent withdrawn into corner opposite to electrified probe compared controls shock-probe...