A5062176464- Pulmonary Hypertension Research and Treatments
- Platelet Disorders and Treatments
- Genetic and Kidney Cyst Diseases
- Hedgehog Signaling Pathway Studies
- Venous Thromboembolism Diagnosis and Management
- Cardiac tumors and thrombi
- Retinal Diseases and Treatments
- Immune cells in cancer
- Biofuel production and bioconversion
- Angiogenesis and VEGF in Cancer
- Microbial Metabolic Engineering and Bioproduction
- Blood properties and coagulation
- Protist diversity and phylogeny
- Multiple Myeloma Research and Treatments
- Chemokine receptors and signaling
- Fungal and yeast genetics research
- Inflammatory Biomarkers in Disease Prognosis
- Microtubule and mitosis dynamics
University of Colorado Anschutz Medical Campus
2023
Color (United States)
2023
Brigham and Women's Hospital
2017-2019
Harvard University
2017
Dana-Farber Cancer Institute
2017
Boston Children's Hospital
2017
Abstract It is now recognized that compounds released from tumor cells can activate platelets, causing the release of platelet-derived factors into microenvironment. Several these have been shown to directly promote neovascularization and metastasis, yet how feedback between platelet releasate cell affects metastatic phenotype remains largely unstudied. Here, we identify breast secrete high levels interleukin 8 (IL-8, CXCL8) in response releasate, which promotes their invasive capacity....
Objective— Platelets, which are mainly known for their role in hemostasis, now to play a crucial metastasis. Tamoxifen is selective estrogen receptor modulator that widely used the treatment of breast cancer. and its metabolites have been shown directly impact platelet function, suggesting this drug has additional mechanisms action. The purpose study was determine whether tamoxifen exerts antitumor effects through direct inhibition. Approach Results— This found pretreatment with leads...
Rationale: Data on the molecular mechanisms that regulate platelet-pulmonary endothelial adhesion under conditions of hypoxia are lacking, but may have important therapeutic implications. Objectives: To identify a hypoxia-sensitive, modifiable mediator artery cell and thrombotic remodeling. Methods: Network medicine was used to profile protein-protein interactions in hypoxia-treated human pulmonary cells. from liquid chromatography-mass spectrometry microscale thermophoresis informed...
The primary cilium is a critical sensory organelle that built of axonemal microtubules ensheathed by ciliary membrane. In polarized epithelial cells, cilia reside on the apical surface and must extend these directly into extracellular space remain stable structure. However, factors regulating cross-talk between ciliation cell polarization, as well as, microtubule growth stabilization in epithelia are not fully understood. this study, we find TTLL12, previously uncharacterized member Tubulin...
The primary cilium is a critical sensory organelle that built of axonemal microtubules ensheathed by ciliary membrane. In polarized epithelial cells, cilia reside on the apical surface and must extend these directly into extracellular space remain stable structure. However, factors regulating cross-talk between ciliation cell polarization, as well microtubule growth stabilization in epithelia, are not fully understood. this study, we find TTLL12, previously uncharacterized member Tubulin...