A5030723830- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Lung Cancer Research Studies
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Cardiac tumors and thrombi
- Neuroendocrine Tumor Research Advances
- Soft tissue tumor case studies
- Long-Term Effects of COVID-19
- Bone Tumor Diagnosis and Treatments
- PARP inhibition in cancer therapy
- Transplantation: Methods and Outcomes
- Tuberous Sclerosis Complex Research
- Tumors and Oncological Cases
- PI3K/AKT/mTOR signaling in cancer
- COVID-19 Clinical Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medical Imaging and Pathology Studies
- Lymphoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Vasculitis and related conditions
- Neuroblastoma Research and Treatments
Mayo Clinic
2021-2025
Mayo Clinic in Arizona
2021-2024
WinnMed
2024
Brigham and Women's Hospital
2020-2023
Boston Children's Hospital
2022
Massachusetts General Hospital
2021
Yale University
2016-2020
Harvard University
2020
Yale New Haven Health System
2018
Sidney Kimmel Comprehensive Cancer Center
2016
Molecular mechanisms of acquired resistance to MET tyrosine kinase inhibitors (TKI) are poorly understood. We aimed characterize the genomic type I and II TKIs their impact on sequential TKI therapy outcomes in patients with metastatic exon 14-mutant NSCLC.Genomic alterations occurring at time progression were studied using plasma tissue next-generation sequencing (NGS).A total 20 had or available for analysis a TKI. Genomic known suspected be detected 15 (75%). On-target resistance,...
Abstract Background In recent years, the fibroblast growth factor receptor (FGFR) pathway has been proven to be an important therapeutic target in bladder cancer. FGFR‐targeted therapies are effective for patients with FGFR mutation, which can discovered through genetic sequencing. However, sequencing is not commonly performed at diagnosis, whereas a histologic assessment of tumor is. We aim computationally extract imaging biomarkers from existing diagnostic slides order predict alterations...
Studies of lungs in patients with COVID-19 have focused on early findings.To systematically study histopathologic and imaging features presence SARS-CoV-2 RNA lung tissue from later stages COVID-19.Autopsies, explants, surgical biopsies, transbronchial cryobiopsies, needle biopsies whose onset symptoms/confirmed diagnosis was more than 28 days before the procedure were studied. Available images reviewed. Reverse transcription droplet digital polymerase chain reaction for performed tissue.Of...
Primary pulmonary myxoid sarcoma (PPMS) and thoracic angiomatoid fibrous histiocytoma (AFH) are rare neoplasms with EWSR1 fusions overlapping morphology. Both tumor types often show epithelial membrane antigen expression, but AFH characteristically co-expresses desmin. We encountered a case of PPMS the unexpected finding patchy, strong anaplastic lymphoma kinase (ALK) (previously reported in AFH) synaptophysin expression. evaluated cohort systematic morphologic comparison surveyed for...
ABSTRACT We report a case of primary cutaneous spindle cell sarcoma (SCS) with FN1 :: FGFR1 fusion. The tumor lacked the typical histologic and immunohistochemical features associated other ‐rearranged neoplasms, such as phosphaturic mesenchymal tumors (PMT) calcified chondroid neoplasms (CCMN). Unlike PMTs, which often feature cartilaginous matrix are tumor‐induced osteomalacia (TIO), present these characteristics did not show FGF23 mRNA expression. Immunohistochemically, cells showed...
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder with variable genetic etiologies. Here, we focused on understanding the precise molecular pathology of a single clinical variant in DSP, gene encoding desmoplakin. We initially identified potentially novel missense desmoplakin (p.R451G) patient diagnosed biventricular ACM. An extensive single-family ACM cohort was assembled, revealing pattern coinheritance for R451G and phenotype. vitro model system using patient-derived induced...
PARP inhibitors target BRCA mutations and defective homologous recombination repair (HRR) for the treatment of epithelial ovarian cancer (EOC). However, HRR-proficient EOC with remains challenging. The objective this study was to determine whether combination triapine (ribonucleotide reductase inhibitor), cediranib (vascular endothelial growth factor receptor tyrosine kinase inhibitor olaparib synergized against wild-type in xenograft mouse models. In addition, mechanisms by which augmented...
SCLC is an aggressive malignancy with poor outcome. Most patients have disease recurrence despite treatments multiple modalities. Subtyping of has been proposed recently, and novel agents targeting specific subtypes are actively being investigated. In this study, we evaluated the plasticity in paired pre- post-treatment samples. The aim was to understand possible subtype evolution after chemotherapy resistance that could lead alternate targeted therapy strategies.A total 68 samples from 32...
Alterations in c-MET, a tyrosine kinase receptor encoded by the MET gene, have been reported approximately 3% of non-small cell lung cancer (NSCLC) cases and carry important treatment implications. The best studied genetic alterations are exon 14 skipping gene amplification; however, rearrangement has also described, multiple fusion partners reported. Recently, METex14-mutated NSCLC, multitarget inhibitors (TKIs), such as crizotinib cabozantinib, well MET-selective TKIs, tepotinib...
Prognostic stratification of pulmonary carcinoids into “typical” and “atypical” categories requires examination large tissue volume. However, there is a need for tools that provide similar prognostic information on small biopsy samples. Ki-67 OTP immunohistochemistry have shown promising value in studies resected carcinoids, but when using biopsy/cytology specimens unclear. was performed from carcinoid tumors (n=139), labeling index scored via automated image analysis at least 500 cells. 70...
Acral fibrochondromyxoid tumor (AFCMT) is a recently described likely benign mesenchymal neoplasm arising in the distal extremities with distinctive histologic features and recurrent THBS1::ADGRF5 fusion. We studied an additional 37 cases of AFCMT expanded on so-far reported clinicopathologic molecular findings. Tumors occurred 21 females 16 males, ranging age from 17 to 78 years (median age: 47), solely involved hands (24/37, 65%) or feet (13/37, 35%). Histologic examination revealed...
Abstract Objectives Checkpoint inhibitor (CPI)–associated colitis can limit therapy and has resemblance to inflammatory bowel disease (IBD). Studies exploring mechanistic similarities between these colitides are limited, yet therapeutic targets for either disorder could emerge from shared pathophysiology. Methods The morphology content of colonic biopsy specimens anti–CTLA-4 anti–PD-1/PD-L1 antibody-treated patients with CPI were compared initial IBD. Predictors the need infliximab sought in...