A5102742802- Analytical Chemistry and Chromatography
- China's Socioeconomic Reforms and Governance
- Teacher Education and Leadership Studies
- Global Education and Multiculturalism
- Metal-Organic Frameworks: Synthesis and Applications
- Chemical Synthesis and Characterization
- Educator Training and Historical Pedagogy
- Education and Critical Thinking Development
- Innovative Education and Learning Practices
- Higher Education Governance and Development
- Lung Cancer Diagnosis and Treatment
- Educational and Psychological Assessments
- Urbanization and City Planning
- Educational Assessment and Improvement
- Polyoxometalates: Synthesis and Applications
- Esophageal Cancer Research and Treatment
- Urban Planning and Governance
- Advanced Chemical Sensor Technologies
- Urban and Rural Development Challenges
- Reflective Practices in Education
- Natural product bioactivities and synthesis
- Crystal Structures and Properties
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- China's Ethnic Minorities and Relations
- RNA modifications and cancer
Taian City Central Hospital
2008-2024
Xiangya Hospital Central South University
2023-2024
Central South University
2023-2024
Peking University
1998-2023
Binzhou University
2010-2023
Binzhou Medical University
2010-2023
Anhui Agricultural University
2023
Beijing Haidian Hospital
2022
Huaqiao University
2021
Chinese Academy of Sciences
2001-2019
PURPOSE This multicenter, randomized, phase III clinical trial (Northern Radiation Oncology Group of China-002) focused on patients with oligo-organ metastatic non–small cell lung cancer (NSCLC) who have epidermal growth factor receptor ( EGFR ) mutations. We aimed to investigate whether first-line concurrent thoracic radiotherapy (TRT) and EGFR-tyrosine kinase inhibitors (TKIs), compared TKIs alone, could achieve better survival. MATERIALS AND METHODS The in the TKI plus TRT group received...
Concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, optimal radiotherapy regimen, particularly in terms of total dose and planned range irradiation field, remains unclear. This phase III clinical trial aimed to compare survival benefits between different radiation doses target fields.
Purpose The purpose of this paper is to examine the cultural roots Chinese lesson study (LS) so as account for its persistence in education history well importance teacher professional development and student learning. Design/methodology/approach overarching research question is: “How can be theorized from a perspective?” sub-questions include: “What features do teachers demonstrate their LS activities? How traditional resources utilized explaining existence these features?” Based on close...
Purpose Although CLS has been implemented in China for over a century, it is barely known to educators internationally. The purpose of this paper synthesize the salient characteristics Chinese lesson study (CLS), introduce major themes special issue, and invite dialogues about theories practices CLS. Design/methodology/approach authors editorial conducted an extensive literature review on CLS, analyzed contents methods existing research categorically, compared with other models LS globally,...
This article examines structural social-psychological and ecological factors affecting the direction types of changes occuring in Chinese family concludes that multiple demographic socioeconomic influences families adaptive responses are creating conditions China for traditional household arrangement to survive while generating new variants organization. The 1-child population policy general modernization exert strong effects on extended structure but robust nature kinship system a...
Previous research concerning teacher practical knowledge has revealed its epistemological foundations, content structure and methodology, but little examines ethical dimension. Based on a four-year project in China, this study probes the dimension of an experienced teacher’s knowledge, explicated dilemmatic teachable moment. Narrative inquiry is used as both method representational form to reveal decisions actions nested macro–meso–micro spaces. It found that embedded complicated web...
Abstract MicroRNAs play an important role in the migration and invasion of tumors, lower expression microRNA-1 (miR-1) has been proven a variety malignant including esophageal squamous cell carcinoma (ESCC). In this study, we found that miR-1 levels tumor tissues preoperative serum from patients were than those non-tumorous healthy volunteers. plasma was closely related to invasion, lymph node metastasis TNM staging. Additionally, positively correlated. inhibited proliferation, invasion....
Abstract Background Previous studies have documented the therapeutic value of computed tomography (CT)‐guided percutaneous microwave ablation (MWA) for early‐stage non‐small cell lung cancer (NSCLC). However, few focused on patients aged 80 years and older. This retrospective study aimed to evaluate safety clinical outcomes CT‐guided MWA in older with peripheral NSCLC. Methods A analysis 63 cT1a‐2bN0M0 NSCLC who underwent was performed between January 2008 2018 at 11 hospitals Shandong...
This article investigates the role played by state in production and management of urban space vis–à–vis global agents change. proliferation new towns special economic zones as restructuring strategies rapidly developing countries like China India are receiving much attention from scholarly community, documenting interrogating transitions centralized planning to more participatory often privatized modes decentralized planning. seeks tease out kinds relationships between other development...
Breast cancer (BC) is the leading cause of cancer‑associated mortality among women worldwide, with a poor 5‑year survival rate, particularly patients metastatic BC. Previous studies have indicated that dysregulation microRNAs (miRNAs/miRs) associated carcinogenesis and metastasis. Thus, investigating underlying molecular mechanisms by which miRNAs mediate their effects may aid in improvement BC treatment. In present study, reverse transcription‑quantitative polymerase chain reaction analyses...
Abstract The adult heart retains a limited ability to regenerate in response injury. Although exercise can reduce cardiac ischaemia/reperfusion (I/R) injury, the relative contribution of cell proliferation including newly formed cardiomyocytes remains unclear. A 4‐week swimming murine model was utilized induce physiological growth. Simultaneously, antineoplastic agent 5‐fluorouracil (5‐FU), which acts during S phase cycle, given mice via intraperitoneal injections. Using EdU and Ki‐67...
Candida africana , an emerging yeast pathogen, is closely related to albicans and most commonly involved in vulvovaginal candidiasis (VVC). However, its prevalence candidal balanoposthitis still unclear. In this study, the of C. both VVC a sexually transmitted diseases (STD) clinic Shanghai, China, was analyzed, molecular characterization susceptible profiles isolates were investigated. As results, only isolated 5 out 79 (6.3%) cases rather than with candidiasis. Among them, 4 share same...
This randomized, multicenter, phase II clinical trial was performed to compare the safety and efficacy of concurrent chemoradiotherapy using S-1 (CCRT) with radiotherapy alone (RT) for elderly patients locally advanced esophageal squamous cell carcinoma (ESCC). All eligible were randomly assigned CCRT group or RT at a 1:1 ratio. The received 50.4 Gy 59.4 alone. primary endpoints toxicity overall response rate (ORR), secondary survival (OS) progression-free (PFS). In total, 157 ESCC recruited...
DNA damage response (DDR) and the centrosome cycle are 2 of most critical cellular processes affecting genome stability in animal cells. Yet cross-talks between DDR poorly understood. Here we showed that deficiency breast cancer 1, early onset gene (BRCA1) induces amplification non-stressed cells as previously reported while attenuating damage-induced (DDICA) experiencing prolonged genotoxic stress. Mechanistically, function BRCA1 promoting DDICA is through binding recruiting polo-like...
Abstract As countries worldwide aim to reform their education systems and improve teaching learning, lesson study (LS), which originated in East Asia, has recently attracted great attention. In order for international educators policy makers better understand the history state of art LS this article introduces three typical models Japan, Mainland China Hong Kong. First, they are described with regard distinct features, historical origin development, goals objectives, mechanisms...
Abstract An excellent pre-column fluorescent derivatization reagent N-acetylhydrazine acridone for the quantitative determination of malondialdehyde was synthesized. Malondialdehyde derivatized at 80 °C 30 min in presence trichloroacetic acid. The separation derivative performed on an Agilent ZORBAX SB-C18 column conjunction with gradient elution. excitation and emission wavelengths were 370 nm 420 nm, respectively. developed method demonstrated good linear relationship range 0.02 pmol to...
RABEX-5, a guanine-nucleotide exchange factor (GEF) for RAB-5, is implicated in tumorigenesis and the development of certain human cancers. Here, we report that RABEX-5 promotes tumor growth metastatic ability gastric cancer cells both vitro vivo. Expression significantly higher tissues associated with size lymph node metastasis. In addition, targeted silencing reduced cell proliferation colony formation via induction G0/G1 phase arrest, stimulated apoptosis. Knockdown also inhibited wound...
Gastric cancer is the fourth most common type of and second leading cause cancer-related death in world. Since patients are often diagnosed at a late stage, very few effective therapies left arsenal. FGF19, as hormone, has been reported to promote tumor growth various types cancer; however, its function gastric remains unknown. In current study, we showed that FGF19 overexpressed associated with depth invasion, lymph node metastasis, TNM stage. addition, vitro experiments demonstrated able...
Objective This study aims to explore the common genetic basis between respiratory diseases and identify shared molecular biological mechanisms. Methods genome-wide pleiotropic association uses multiple statistical methods systematically analyse five (asthma, chronic obstructive pulmonary disease, idiopathic fibrosis, lung cancer snoring) using largest publicly available genome wide studies summary statistics. The missions of this are evaluate global local correlations, loci, elucidate...