A5100442019- Protein Degradation and Inhibitors
- Retinal Imaging and Analysis
- Ubiquitin and proteasome pathways
- Retinal Diseases and Treatments
- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
- Glaucoma and retinal disorders
- Click Chemistry and Applications
- Lipid Membrane Structure and Behavior
- Optical Coherence Tomography Applications
- CRISPR and Genetic Engineering
- Cell death mechanisms and regulation
- Multiple Myeloma Research and Treatments
- Cancer therapeutics and mechanisms
- Retinal and Optic Conditions
- Metal complexes synthesis and properties
- Chemical Synthesis and Analysis
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Research Studies
- Ocular Diseases and Behçet’s Syndrome
- Drug Transport and Resistance Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Gut microbiota and health
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
Binzhou University
2022-2025
Binzhou Medical University
2022-2025
Shihezi University
2025
Center for Excellence in Molecular Cell Science
2025
University of Chinese Academy of Sciences
2025
Shandong University of Technology
2024
Shandong First Medical University
2019-2024
Shandong University
2015-2024
Shandong Provincial Institute of Dermatology and Venereology
2020-2024
Central South University
2016-2024
The binding interactions of simvastatin (SIM), pravastatin (PRA), fluvastatin (FLU), and pitavastatin (PIT) with bovine serum albumin (BSA) were investigated for determining the affinity four statins BSA through multiple spectroscopic molecular docking methods. experimental results showed that SIM, PRA, FLU, PIT quenched intrinsic fluorescence a static quenching process stable stains–BSA complexes constants in order 104 M−1 at 298 K formed intermolecular nonbond interaction. values ΔH0, ΔS0...
Abstract Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers, and it requires novel treatment approaches effective drugs. In present study, we found that with plumbagin, a natural compound, reduced proliferation survival KYSE150 KYSE450 ESCC lines in dose-dependent manner vitro. The drug also effectively inhibited viability primary cells from fresh biopsy specimens. Furthermore, plumbagin-induced mitotic arrest massive apoptosis cells. Notably, significantly suppressed...
The E2F family of transcription factors play a crucial role in the development various cancers. However, members lack targetable binding pockets and are typically considered "undruggable". Unlike canonical small-molecule therapeutics, molecular glues mediate new E3 ligase-protein interactions to induce selective proteasomal degradation, which represents an attractive option overcome these limitations.Human proteome microarray was utilized identify natural product-derived glue for targeting...
A highly efficient one-pot transamidation of primary amides has been developed under transition-metal free conditions, generating a variety including hindered in good yield (up to 86%) catalyzed by CsF.
A variety of myricetin derivatives bearing ferulic acid amide scaffolds were designed and synthesized.
LU·MH regulates lipid metabolism signaling pathways and intestinal flora to alleviate disorders of high-fat diet mice.
PURPOSE This multicenter, randomized, phase III clinical trial (Northern Radiation Oncology Group of China-002) focused on patients with oligo-organ metastatic non–small cell lung cancer (NSCLC) who have epidermal growth factor receptor ( EGFR ) mutations. We aimed to investigate whether first-line concurrent thoracic radiotherapy (TRT) and EGFR-tyrosine kinase inhibitors (TKIs), compared TKIs alone, could achieve better survival. MATERIALS AND METHODS The in the TKI plus TRT group received...
JAK2/STAT3/MYC axis is dysregulated in nearly 70 % of human cancers, but targeting this pathway therapeutically remains a big challenge cancer therapy. In study, genes associated with JAK2, STAT3, and MYC were analyzed, potential target selected. Leucine-rich PPR motif-containing protein (LRPPRC) whose function regulation are not fully understood, emerged as one top 3 terms RNA epigenetic modification. Here, we demonstrate LRPPRC may be an independent prognostic indicator besides MYC....
Immune checkpoint blockades (ICBs) are promising, however they do not fit all types of tumor, such as those lack tumor antigens. Induction potent anti-tumor T cell immunity is critical for cancer therapy. In this study, we investigated the efficacy immunotherapy via immunogenic death (ICD) dying cells in mouse models lung metastasis and tumorigenesis. ICD was induced by short exposure to lethal dose chemotherapeutic drug doxorubicin (Dox), which initiated an irreversible program cells. We...
This study aimed to investigate the effects of adding Qiamagu polysaccharides feed on growth performance, immunity and gut health yellow-feathered broilers. A total 240 healthy, day-old, male broiler chickens with similar body weights were randomly divided into four groups, each six replicates 10 per replicate. The groups consisted a control group (CON) three treatment groups: TP1 (250 mg/kg), TP2 (500 TP3 (1000 mg/kg) polysaccharide in diet, feeding period 64 days. average daily weight gain...
Hepatic fibrosis (HF) is a typical consequence in the development of multiple chronic liver diseases, which intimately related to composition and metabolic status gut microbiota. A myriad evidence has indicated that traditional Chinese medicine can treat HF by regulating Yinchen Wuling powder (YCWLP) famous prescription, been used relieve diseases for thousands years. YCWLP demonstrated protective function on HF, but its effect alterations microbiota still unclear, explicit therapeutic...
Abstract: The purpose of this study was to prepare Brucea javanica oil cationic nanoemulsions (BJO-CN) with BJO as drug well phase and chitosan inducer, explore the practical suitability using for oral delivery mixed oil, test its bioavailability antitumor effect. BJO-CN prepared by solution stirring method then characterized physicochemically. obtained had a spherical morphology positive zeta potential 18.9 mV an average particle size 42.36 nm, showing high colloidal stability. loading...
Histone deacetylases (HDACs) are promising therapeutic targets for the treatment of cancer, diabetes and other human diseases. HDAC inhibitors, as a new class potential agents, have attracted great deal interest both research clinical applications. Increasing efforts been focused on discovery inhibitors some approved use in cancer therapy. However, most including clinically do not selectively inhibit deacetylase activity I II isforms, many suffer from metabolic instability. This study aims...