A5100718157- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Calcium signaling and nucleotide metabolism
- Gut microbiota and health
- Ginseng Biological Effects and Applications
- interferon and immune responses
- Pancreatic function and diabetes
- Gastrointestinal motility and disorders
- Metabolomics and Mass Spectrometry Studies
- Tissue Engineering and Regenerative Medicine
- Neurogenesis and neuroplasticity mechanisms
- Congenital heart defects research
- Immune responses and vaccinations
- Hair Growth and Disorders
- Photodynamic Therapy Research Studies
- Congenital gastrointestinal and neural anomalies
- Moringa oleifera research and applications
- Natural Antidiabetic Agents Studies
- Reconstructive Surgery and Microvascular Techniques
- Retinoids in leukemia and cellular processes
- Helicobacter pylori-related gastroenterology studies
- Breast Implant and Reconstruction
- Advanced Photocatalysis Techniques
- Lymphatic Disorders and Treatments
- Photoacoustic and Ultrasonic Imaging
Shanxi University
2025
Nanjing Agricultural University
2025
Shanxi University of Traditional Chinese Medicine
2025
Shenyang Pharmaceutical University
2021-2025
The University of Texas Southwestern Medical Center
2024
Northwest A&F University
2024
University of Macau
2019-2023
Huaibei Normal University
2023
Institute of Food Science and Technology
2022
Chinese Academy of Agricultural Sciences
2022
Pyruvate is a key metabolite in glycolysis and the tricarboxylic acid (TCA) cycle. Exogenous pyruvate modulates metabolism, provides cellular protection, essential for maintenance of human preimplantation embryos embryonic stem cells (hESCs). However, little known about how contributes to cell-fate determination during epiblast stage. In this study, we used hESCs as model demonstrate that elevated exogenous shifts metabolic balance toward oxidative phosphorylation both differentiation...
Hepatic fibrosis (HF) is a typical consequence in the development of multiple chronic liver diseases, which intimately related to composition and metabolic status gut microbiota. A myriad evidence has indicated that traditional Chinese medicine can treat HF by regulating Yinchen Wuling powder (YCWLP) famous prescription, been used relieve diseases for thousands years. YCWLP demonstrated protective function on HF, but its effect alterations microbiota still unclear, explicit therapeutic...
In order to improve the flavor and taste of Camembert cheese, use Monascus as an adjunct starter for production Camembert-type cheese was studied investigate its effect on proteolysis, lipolysis, volatile compounds during ripening 40 days. The without used a control. results showed that proteolytic lipolytic activities increased certain extent. addition promoted primary secondary due release some proteases by Monascus. Aspartic, Threonine, Glutamic, Glycine, Methione, Isoleucine,...
ABSTRACT Sangge Jiangzhi pill, as a traditional Chinese medicine compound preparation, can be used to treat hyperlipidemia. However, the specific material basis and mechanism of action pill are not clear. In this study, gut microbiota host metabolism were investigated using 16S rRNA sequencing metabolomics techniques. The changes in body weight, organ index, serum biochemical levels, liver pathology demonstrated that reduced weight attenuated fat accumulation hyperlipidemic rats. results...
Ethnopharmacological relevanceAs a classic formula, Ermiao San (EMS) characterized by its less medicinal flavor and strong potency had been proven to be effective safe in the treatment of rheumatoid arthritis (RA) during clinical experience our previous research.Aim studyThe therapeutic characteristics multi-component multi-target traditional Chinese medicine prompted us further investigated compounds EMS, evaluated potential mechanisms treating RA.Materials methodsFirstly,...
Abstract Background Vitamin B3 (nicotinamide) plays important roles in metabolism as well SIRT and PARP pathways. It is also recently reported a novel kinase inhibitor with multiple targets. Nicotinamide promotes pancreatic cell differentiation from human embryonic stem cells (hESCs). However, its molecular mechanism still unclear. In order to understand the involved fate determination, we analyzed downstream pathways of nicotinamide derivation NKX6.1 + progenitors hESCs. Methods We applied...
Abstract Mesenchymal stem/Stromal cells (MSCs) have great therapeutic potentials, and they been isolated from various tissues organs including definitive endoderm (DE) organs, such as the lung, liver intestine. MSCs induced human pluripotent stem (hPSCs) through multiple embryonic lineages, mesoderm, neural crest, extraembryonic cells. However, it remains unclear whether hPSCs could give rise to in vitro endodermal lineage. Here, we report that hPSC-derived, SOX17 + progenitors can further...
Phosphors with a longer excitation wavelength exhibit higher energy conversion efficiency. Herein, quantum cutting KGd(CO3)2:Tb3+ phosphors excited by middle-wave ultraviolet were synthesized via hydrothermal method. All the KGd(CO3)2:xTb3+ remain in monoclinic structures large Tb3+ doping range. In KGd(CO3)2 host, 6D3/2 and 6I17/2 of Gd3+ employed for sensitizing levels. The state electrons could easily transfer from to high There are three efficient bands cutting. wavelengths 244, 273, 283...
Anthocyanins are a kind of glycoside derivatives with C6-C3-C6 as the skeleton widely existing in various fruits and vegetables. In addition to giving food its bright color, anthocyanins have variety biological health effects on human body. this paper, structure, distribution, content research progress their metabolites intestinal microbiological regulation recent years were reviewed order provide theoretical basis for further development nutritive healthy rich anthocyanins.
Abstract Constipation and stercoral ulcer are risk factors associated with Hirschsprung's disease (HD); long‐term follow‐up is, thus, essential. In postoperative HD Down syndrome (DS) intellectual disability, vigilant is required to avoid severe constipation because DS predisposes the patients caregivers cannot easily understand symptoms.
Abstract This is the first case report comparing endoscopic images of primary intestinal lymphangiectasia (PIL) over 10 years. Regular examination essential in PIL because findings do not correlate well with clinical manifestations.
Uremic Clearance Granule (UCG) is a traditional Chinese medicines (TCMs) that has been recognized as potentially effective treatment for diabetic nephropathy (DN). However, the chemical composition and hypoglycemic ingredients of UCG remain unclear. In this experiment, magnetic ligand fishing protocol combined with HPLC coupled Fourier transform ion cyclotron resonance mass spectrometry (HPLC-FT-ICR-MS) technology was developed to screen identify α-Glucosidase inhibitors from UCG. First,...
Epidermal stem cells control homeostasis and regeneration of skin hair. In the hair follicle (HF) bulge mammals, populations slow-cycling regenerate HF during cyclical rounds anagen (growth), telogen (quiescence), catagen (regression). Multipotent epidermal are also present in above area, contributing to formation maintenance sebaceous gland upper middle portions HF. Here, we report that transcription factor Krox20 is enriched an cell population located upper/ Expression analyses lineage...
Objective To observe the clinical effect and economic utility of self-designedvestlike dressing device in patients with breast cancer after operation.Methods Sixty who met inclusion criteria were randomly divided into self-made vestlike group (the observation group) self-adhesive elastic bandage control group),each 30 cases.The quantity postoperative drainage,the time intubation,the rate subcutaneous hydrops flap necrosis,the degree discomfort compared between two groups.Results The...
Objective To explore the value of applying helicobacter pylori typing in diagnosis and treatment children with recurrent abdominal pain (RAP). Methods 140 RAP highly suspicious gastritis were selected as an experimental group, 140 taking physical examination at same time a control group. 13C-UBT performed both groups, their H.pylori positive rates represented P1 P2. The (+) group took serotyping detection (type Ⅰ, type Ⅱ, middle type), gastroscopy time; according to degree gastric...
Danyikangtai powder has a definite therapeutic effect on pancreatitis. However, the internal mechanism is unclear. The purpose of this experiment to quickly identify blood components danyikangtai and evaluate its efficacy. 25 were identified by comparing with same mass spectrometry information from in vivo vitro samples. AR42J cells pancreatitis model treated drug-containing plasma, drug efficacy was evaluated investigating amylase release rate. This study provides scientific reference for...