A5101769974- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Paraoxonase enzyme and polymorphisms
- Pediatric health and respiratory diseases
- Lung Cancer Research Studies
- Apelin-related biomedical research
- Nuclear Receptors and Signaling
- Cancer Immunotherapy and Biomarkers
- Anorectal Disease Treatments and Outcomes
- Advanced Radiotherapy Techniques
- Pelvic floor disorders treatments
- Cytokine Signaling Pathways and Interactions
- Neonatal Respiratory Health Research
- Food Chemistry and Fat Analysis
- Medicinal Plant Pharmacodynamics Research
- Oral health in cancer treatment
- Synthesis and Biological Evaluation
- Cancer-related molecular mechanisms research
- Food composition and properties
- Tissue Engineering and Regenerative Medicine
- Gastrointestinal motility and disorders
- Colorectal and Anal Carcinomas
- NF-κB Signaling Pathways
- Advanced biosensing and bioanalysis techniques
- Reproductive Biology and Fertility
Binzhou University
2015-2024
Binzhou Medical University
2015-2024
Inner Mongolia University of Science and Technology
2022-2024
Baotou Medical College
2022
Tianjin Medical University
2022
Shanxi Medical University
2009-2021
Shaanxi Provincial People's Hospital
2009-2021
Agriculture and Food
2021
Commonwealth Scientific and Industrial Research Organisation
2021
Third Hospital of Hebei Medical University
2019
PURPOSE This multicenter, randomized, phase III clinical trial (Northern Radiation Oncology Group of China-002) focused on patients with oligo-organ metastatic non–small cell lung cancer (NSCLC) who have epidermal growth factor receptor ( EGFR ) mutations. We aimed to investigate whether first-line concurrent thoracic radiotherapy (TRT) and EGFR-tyrosine kinase inhibitors (TKIs), compared TKIs alone, could achieve better survival. MATERIALS AND METHODS The in the TKI plus TRT group received...
Patients with Eastern Cooperative Oncology Group performance status (ECOG PS) 2 probably cannot tolerate chemotherapy or other antitumor therapies. Some studies have reported that immunotherapy combined antiangiogenic therapy is well-tolerated and shows good activity. However, the efficacy of this combination as a later-line in patients ECOG PS unclear. This study evaluated effectiveness safety strategy third- further-line stage IV non-small cell lung cancer (NSCLC) 2.
To retrospectively analyze and compare the outcomes of patients with hepatocellular carcinoma treated either surgical excision or CyberKnife® from September 2006 to August 2011.Local control toxicity were primary endpoints, followed by local progression-free survival, overall survival as secondary endpoints. Response Evaluation Criteria In Solid Tumors evaluation criteria for efficacy; Common Toxicity 3.0 adverse events. Local was calculated using direct method (nonactuarial). The curves...
miR-203 is known to target estrogen receptor α (ERα) in various cancer cell lines, such as MCF-7. However, whether regulates ERα and contributes the onset progression of osteoarthritis (OA) poorly understood. A combined protocol bilateral ovariectomy intra-articular monosodium iodoacetate injection was applied establish a postmenopausal OA model rats. Real-time quantitative polymerase chain reaction used detect mRNAs Western blotting exploited quantify expression levels on protein level....
Neurogenic locus notch homolog protein (Notch) signaling mediates intracellular communication and may regulate cell fate decisions, including proliferation, differentiation, apoptosis. Mesenchymal stem cells (MSCs) possess immunomodulatory properties the potential for use in replacement treatments. The aim of present study was to evaluate therapeutic effects human placenta‑deviated MSCs (hPMSCs) asthma investigate mechanisms Notch mediated by transplanted MSCs. A Sprague‑Dawley rat ovalbumin...
Small quantities of lipids accumulate in the white rice grains. These are grouped into non-starch lipid and starch fractions that affect properties through association with starch. Lysophosphatidylcholine (LPC) lysophosphatidylethanolamine (LPE) two major classes fractions. Using high-oleic grains, we investigated fatty-acid composition flour by LC-MS evaluated its impact on properties. In wild-type grain, nearly 50% fatty acids LPC LPE were palmitic acid (C16:0), over 20% linoleic (C18:2)...
Episil is a bioadhesive barrier-forming liquid gel that can relieve mucositis caused by radiotherapy (RT) and effectively pain. The purpose of this trial to compare the efficacy safety in improving acute radiation dermatitis (ARD) patients with breast cancer. This study included who met criteria for postoperative RT primary end point was grade RD during treatment. A total 102 were study. grouped 2:1 ratio using randomized number table method: 67 received combined conventional skin care (the...
Uterus is an important reproductive organ for embryonic growth and development of viviparous animals. Its normal function regulated by complex endocrine system multiple genes. NRDR a retinoic acid metabolizing enzyme with strong retinol oxidation retinoaldehyde reduction activities. in the has been partially studied. In this study, expression distribution change different physiological states developmental stages mouse uterus will be clarified, so as to provide experimental basis further...
To evaluate the efficacy and safety of combined-modality therapy for elderly patients with locally advanced non-small-cell lung cancer (NSCLC) invading chest wall.We retrospectively enrolled 21 (aged ≥60 years) NSCLC wall. For external beam radiotherapy (EBRT) primary tumor, 40Gy was applied supplemented iodine-125 seed implantation while 60Gy to lymph nodes mediastinum. Follow-up conducted every 3 months postoperatively. The related analytic parameters were change in tumor size, objective...
Abstract Background: Estrogen receptor (ESR1) mutations occur at a high frequency in metastatic breast tumors patients treated with hormonal therapy the setting. We do not know if these are involved metastasis. Experimental design and methods: generated ESR1 Y537S homozygous using CRISPR Casp-9 technology. Treatment synergy was evaluated Compusyn. Athymic mice were used tumor xenograft studies. ChIP-Seq transcriptome analyses performed. Results: mutation knock-in clones lentiviral stable...
Abstract Background Our retrospective study aimed to evaluate the efficacy and safety of combined-modality therapy for tumor invading chest wall locally advanced non-small-cell lung cancer (NSCLC) in elderly. Methods We retrospectively enrolled 21 elderly patients (aged ≥ 60 years) with NSCLC diagnosed as wall. The prescription dose primary adopting external beam radiotherapy (EBRT) was given 40 Gy which supplemented iodine-125 seed implantation, meanwhile lymph nodes mediastinum undergoing...
e16086 Background: Concurrent chemoradiotherapy (CCRT) is the standard therapy for locally advanced unresectable esophageal squamous cell cancer (ESCC)，However, some patients cannot tolerate or are unwilling to CCRT. The aim of this phase II trial was assess efficacy and safety tirelizumab combined with radiotherapy in ESCC. Methods: Key eligibility criteria were as follows: ESCC clinical stage Ⅱ-Ⅳa; aged 18 90 years; CCRT; ECOG performance status 0 1; performed radiotherapy: Involvement...