A5101984653- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Vector-borne infectious diseases
- Insect symbiosis and bacterial influences
- Gut microbiota and health
- Cephalopods and Marine Biology
- Parasites and Host Interactions
- Antibiotic Resistance in Bacteria
- Plant and Fungal Interactions Research
- Neurobiology and Insect Physiology Research
- Molecular Biology Techniques and Applications
- Extracellular vesicles in disease
- Yersinia bacterium, plague, ectoparasites research
- Aquaculture disease management and microbiota
- Clostridium difficile and Clostridium perfringens research
- Escherichia coli research studies
- Glaucoma and retinal disorders
- Helminth infection and control
- Circular RNAs in diseases
- Reproductive tract infections research
- Dermatological diseases and infestations
- Forest Ecology and Biodiversity Studies
- Parasitic Infections and Diagnostics
- bioluminescence and chemiluminescence research
Chengdu Research Base of Giant Panda Breeding
2008-2025
State Forestry and Grassland Administration
2020-2025
BGI Group (China)
2021
The gut microbiota of the giant panda (Ailuropoda melanoleuca), a global symbol conservation, are believed to be involved in host's dietary switch fibrous bamboo diet. However, their exact roles still largely unknown.In this study, we first comprehensively analyzed large number metagenomes pandas (n = 322), including 98 sequenced study with deep sequencing (Illumina) and third-generation (nanopore). We reconstructed 408 metagenome-assembled genomes (MAGs), 148 which (36.27%) were near...
In this study, we have successfully constructed a comprehensive database of metagenome-assembled genomes (MAGs) pertaining to the gut microbiota giant panda. Through our analysis, identified significant reservoirs antibiotic resistance genes (ARGs), namely
A female giant panda presented with a large, hard mass on the right cheek, which was investigated at Dujiangyan Base of China Conservation and Research Center for Giant Panda computed tomography (CT) scans biopsy oral mass, as well venous blood sampling. Hematological tests revealed elevated levels tumor marker CA724, along infectious disease, anemia, hepatic damage, renal failure. Imaging studies identified soft tissue in cheek area. Macroscopic pathological changes, histopathological...
Giant pandas ( Ailuropoda melanoleuca ) belong to the order Carnivora, but they mainly feed on bamboo, and their unique dietary adaptability has always been focus of research. Recent research indicates that plant-derived microRNAs (miRNAs) can be delivered animal organisms via exosomes exert cross-kingdom regulatory effects gene expression. To explore role miRNAs in adaptation giant pandas, we collected peripheral blood samples from three groups pandas: juvenile females, adult males—and...
Escherichia coli (E. coli) plays an important ecological role, and is a useful bioindicator to recognize the evolution of resistance in human, animal environment. Recently, extended-spectrum β-lactamases (ESBL) producing E.coli has posed threat public health. Generally, captive healthy giant pandas are not exposed antibiotics; however, they still acquire antimicrobial resistant bacteria. In order understand whether there exchange genes within ecosystems pandas, this study explored...
Giant pandas have a high incidence of tooth wear, loss, and fracture since their diet is specifically bamboo. Dental implantation common treatment for loss in humans while rarely reported wild animals. To explore the applicability dental giant pandas, this study measured mandible parameters panda, from an adult skeletal specimen. The bone block model was developed using computer-aided design 3D mechanical drawing software. Implants different radius thread types third premolar (PM3) were...
Vision plays a crucial role in the survival of animals, and visual system has particularly selectively evolved response to environment, ecological niche, species habitats vertebrate species. To date, horizontal streak retinal ganglion cell (RGC) distribution pattern is observed across mammal Here, we report that giant panda's vertically oriented streak, combined with current evidence animal's forward-placed eyes, ocular structure, neural topographic patterns, presents emergence well-adapted...
Gene differential expression studies can serve to explore and understand the laws characteristics of animal life activities, difference in gene between different tissues has been well demonstrated studied. However, for world-famous rare protected species giant panda (Ailuropoda melanoleuca), only transcriptome blood spleen reported separately. Here, order differences panda, profiles heart, liver, spleen, lung, kidney from five captive pandas were constructed with Illumina HiSeq 2500...
The blood-sucking tick Haemaphysalis hystricis is a common ectoparasite of the giant panda and represents significant threat to both wild captive populations. Herein, complete mitogenome H. was sequenced using Illumina sequencing technology. sequence 14,715 bp in size encoded 37 genes including 13 protein-coding genes, 22 transfer RNAs, two ribosomal RNAs. Phylogeny revealed that isolates hystricis, regardless host origins locations, grouped together had closer relationship with longicornis...
Helminth diseases have long been a threat to the health of humans and animals. Roundworms are important organisms for studying parasitic mechanisms, disease transmission prevention. The study parasites in giant panda is importance understanding how roundworms adapt host. Here, we report high-quality chromosome-scale genome Baylisascaris schroederi with size 253.60 Mb 19,262 predicted protein-coding genes. We found that gene families related epidermal chitin synthesis environmental...
The tick Haemaphysalis flava (Acari, Ixodidae) is an obligatory blood-feeding ectoparasite of the giant panda and also a vector for transmission pathogenic microorganisms. In this study, complete mitochondrial genome was sequenced through Illumina sequencing technology. 14,699 bp in length encoded 37 genes including 13 protein-coding genes, 22 transfer RNAs two ribosomal RNAs. Phylogeny revealed that three isolates H. flava, regardless host origins locations, clustered together formed...
Giant panda (Ailuropoda melanoleuca) is an endangered mammalian species. Exploring immune and metabolic changes that occur in giant pandas with age important for their protection. In this study, we systematically investigated the physiological biochemical indicators blood, as well transcriptome, methylation profiles of young, adult, old pandas. The white blood cell (WBC), neutrophil (NEU) counts hemoglobin (HGB) concentrations increased significantly (young to adult), some related glucose...
Haemaphysalis longicornis (Ixodida: Ixodidae) is a common blood-feeding ectoparasite of the giant panda and poses significant health burden to wild captive populations. In present study, complete mitogenome tick H. was sequenced using Illumina sequencing technology. The entire 14,706 bp in length encoded 37 genes including 13 protein-coding genes, 22 transfer RNAs two ribosomal RNAs. Phylogeny showed that four isolates longicornis, regardless host origins or locations, clustered together had...
Proper feeding and nutrition are vital for maintaining the health of giant pandas (GPs), yet impact dietary changes gut microbiota on their nutrient utilization remains unclear. To address these uncertainties, we investigated intake apparent digestibility, as well composition across different age groups pandas: sub-adults (SGPs), adults (AGPs), geriatrics (GGPs). Our findings revealed notable shifts in patterns from SGPs to GGPs. As they aged, significantly more bamboo shoots less were...
In recent years, several giant pandas have suffered from testicular tumor, which has seriously affected panda health. However, the pathogenesis of tumor in is still unclear. Studies shown that miRNAs are involved occurrence and development a variety cancers. effect on been little studied. Therefore, this study explored through miRNA mRNA sequencing, screened out diagnostic markers tumor. Combined with phenotypic symptoms pathological section results, three were diagnosed divided into group,...
A low reproductive rate coupled with human activities has endangered the giant panda, a species endemic to southwest China. Although pandas feed almost exclusively on bamboo, they retain carnivorous traits and suffer from diseases. Additionally, their immune system is susceptible aging, resulting in reduced ability respond This study aimed determine genes pathways expressed differentially age blood tissues. The different groups of were identified by RNA-seq. elderly had many compared young...
Baylisascaris schroederi is one of the main health risks threatening both wild and captive giant pandas. The administration anthelmintics a common method to effectively control B. infection, but there notable risk anthelmintic resistance (AR) after long-term, constant use anthelmintics. Four anthelmintics-pyrantel pamoate (PYR), mebendazole (MBZ), albendazole (ABZ), ivermectin (IVM)-were each administered separately at intervals 2 months 22 enrolled fecal egg count reduction (FECR)...
Helminth diseases have long been a threat to the health of humans and animals. Roundworms are important organisms for studying parasitic mechanisms, disease transmission prevention. The study parasites in living fossil giant panda is great significance understanding adaptation mechanism roundworms host. Here, we report high-quality chromosome-scale genome Baylisascaris schroederi with size 262 Mb 19,291 predicted protein-coding genes. We found significant expansion genes related epidermal...