A5023504231- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Aquaculture disease management and microbiota
- Amphibian and Reptile Biology
- Identification and Quantification in Food
- Genetic and phenotypic traits in livestock
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- RNA Research and Splicing
- Genetic Mapping and Diversity in Plants and Animals
- RNA modifications and cancer
- Pharmaceutical and Antibiotic Environmental Impacts
- Wildlife Ecology and Conservation
- Circular RNAs in diseases
- Primate Behavior and Ecology
- Antibiotic Resistance in Bacteria
- Epigenetics and DNA Methylation
- Dietary Effects on Health
- Plant Virus Research Studies
- Lung Cancer Research Studies
- Probiotics and Fermented Foods
Sichuan Agricultural University
2016-2025
Ministry of Agriculture and Rural Affairs
2022-2024
Fujian Electric Power Survey & Design Institute
2024
Brandenburg University of Technology Cottbus-Senftenberg
2024
Chengdu University
2022
Southwest Medical University
2015-2021
Sun Yat-sen University
2020-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
National Natural Science Foundation of China
2021
West China Medical Center of Sichuan University
2021
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global health emergency, and its gene mutation evolution further posed uncertainty epidemic risk. Herein, we reported light-up CRISPR-Cas13 transcription amplification method, which enables the detection SARS-CoV-2 mutated variants. Sequence specificity was ensured by both ligation process Cas13a/crRNA recognition, allowing us to identify viral RNA mutation. Light-up aptamer allows sensitive output signals...
Betaine is a natural compound present in commonly consumed foods and may have potential role the regulation of glucose lipids metabolism. However, underlying molecular mechanism its action remains largely unknown. Here, we show that supplementation with betaine contributes to improved high-fat diet (HFD)-induced gut microbiota dysbiosis increases anti-obesity strains such as
Musk, secreted by the musk gland of adult male musk-secreting mammals, holds significant pharmaceutical and cosmetic potential. However, understanding molecular mechanisms secretion remains limited, largely due to lack comprehensive multiomics analyses available platforms for relevant species, such as muskrat (Ondatra zibethicus Linnaeus) Chinese forest deer (Moschus berezovskii Flerov). We generated chromosome-level genome assemblies 2 species Flerov), along with 168 transcriptomes from...
Abstract Rex rabbit is an important small herbivore for fur and meat production. However, little known about the gut microbiota in rex rabbit, especially regarding their relationship with different fecal types growth of hosts. We characterized both hard soft feces from rabbits high low body weight by using Illumina MiSeq platform targeting V4 region 16S rDNA. High possess distinctive feces, but not group. detected overrepresentation several genera such as YS2/Cyanobacteria Bacteroidales...
Abstract A comprehensive transcriptomic survey of pigs can provide a mechanistic understanding tissue specialization processes underlying economically valuable traits and accelerate their use as biomedical model. Here we characterize four transcript types (lncRNAs, TUCPs, miRNAs, circRNAs) protein-coding genes in 31 adult pig tissues two cell lines. We uncover the variability among 47 skeletal muscles, six adipose depots linked to different origins, metabolism, composition, physical...
Captive breeding has been used as an effective approach to protecting endangered animals but its effect on the gut microbiome and conservation status of these species is largely unknown. The giant panda a flagship for wildlife. With integrated efforts including captive breeding, this recently upgraded from "endangered" "vulnerable" (IUCN 2016). Since large proportion (21.8%) their global population still captive, it critical understand how captivity changes pandas such alterations might...
Microbial communities of human gut directly influence health and bear adaptive potential to different geography environment lifestyles. However, knowledge about the influences altitude on microbiota Tibetans is currently limited. In this study, fecal from 208 across six locations were analyzed by MiSeq sequencing; these included Gannan, Gangcha, Tianzhu, Hongyuan, Lhasa Nagqu, with altitudes above sea level ranging 2800 m 4500 Tibetan plateau. Significant differences observed in microbial...
Abstract Folliculogenesis is a complex biological process involving central oocyte and its surrounding somatic cells. Three-dimensional chromatin architecture an important transcription regulator; however, little known about dynamics role in transcriptional regulation of granulosa cells during chicken folliculogenesis. We investigate the transcriptomic over ten follicular stages assess how it influences gene expression at three key stages: prehierarchical small white follicles, first largest...
This study set out to investigate the relationship between gut microbiota composition and host adaptation high altitude conditions. Fecal samples from both low humans pigs were studied using multi-omics methods. 16S ribosomal meta-analysis results showed significant differences in bacterial diversity members of same species, as well different species. Acinetobacter, Pseudomonas, Sphingobacterium three most abundant genera found fecal pigs. The alpha diversities Chinese people be relatively...
Aflatoxin B1 (AFB1) leads to a major risk poultry and its residues in meat products can also pose serious threat human health. In this study, after feeding 165-day-old Roman laying hens for 35 days, the toxic effects of aflatoxin at different concentrations were evaluated. The purpose study was explore mechanism liver toxicosis responses AFB1. We found that highly group exposure resulted fat deposition, increased interstitial space, hepatocyte apoptosis hens. Furthermore, total 164...
The red panda is the only living species of genus Ailurus. Like giant pandas, pandas are also highly specialized to feed mainly on fibrous bamboo. Although several studies have focused gut microbiota in panda, little known about panda. In this study, we characterized fecal from both wild (n = 16) and captive 6) using a pyrosequecing based approach targeting V1-V3 hypervariable regions 16S rRNA gene. Distinct bacterial communities were observed between two groups membership structure. Wild...
Bamboo-eating giant panda (Ailuropoda melanoleuca) is an enigmatic species, which possesses a carnivore-like short and simple gastrointestinal tract (GIT). Despite the remarkable studies on panda, its diet adaptability status continues to be matter of debate. To resolve this puzzle, we investigated functional potential gut microbiome using shotgun metagenomic sequencing fecal samples. We also compared our data with similar from other animal species representing herbivores, carnivores,...
A close relationship between age and gut microbiota exists in invertebrates vertebrates, including humans.Long-living people are a model for studying healthy aging; they also have distinctive structure.The the of long-living aging phenotype remains largely unknown.Herein, feces were transplanted into mice, which then examined agingrelated indices beneficial bacteria.Mice with fecal matter from (L group) had greater α diversity, more probiotic genera (Lactobacillus Bifidobacterium),...
The gut microbiota plays a critical role in the growth, development, nutritional digestion, and overall health of chickens. Furthermore, certain probiotics isolated from poultry intestines have demonstrated potential to enhance immune function production performance To investigate differences among chickens various geographical environments different breeds broiler laying hens, we conducted 16S rRNA sequencing on fecal 140 Chinese native ten Roman layers. In addition, screened examine their...
The independent dietary shift from carnivore to herbivore with over 90% being bamboo in the giant and red pandas is of great interests biologists. Although previous studies have shown convergent evolution at both morphological molecular level, gut microbiota these remains largely unknown. goal this study was determine whether converged due same diet, or diverged. We characterized fecal two species by pyrosequencing 16S V1-V3 hypervariable regions using 454 GS FLX Titanium platform. also...
Abstract The occurrence of an inherent or acquired resistance to temozolomide ( TMZ ) is a major burden for patients suffering from glioma. Recently, studies have demonstrated that micro RNA s play important role in the regulation tumor properties cancers. However, whether miR‐497 contributes glioma chemotherapy not fully understood. In this study, we showed expression was markedly up‐regulated ‐resistant cells; high level associated with phenotype cells. down‐regulation cells enhanced...
While the skin microbiome has been shown to play important roles in health and disease several species, effects of altitude on how high-altitude microbiomes may be associated with states remains largely unknown. Using 16S rRNA marker gene sequencing, we characterized people from two racial groups (the Tibetans Hans) three local pig breeds (Tibetan pig, Rongchang Qingyu pig) at high low altitudes. The microbial communities low-altitude pigs humans were distinct those humans, five bacterial...
During the entire growth process, gut microbiota continues to change and has a certain impact on performance of broilers. Here, we used 16S rRNA gene sequencing explore dynamic changes in fecal bacterial communities functions 120 broilers from 4 16 weeks age. We found that main phyla (
The use of single-cell sequencing technology for transcriptomics studies in pigs is expanding progressively. However, the comprehensive classification cell types across different anatomical tissues and organs pig multiple datasets remains relatively limited. This study employs single-nucleus technologies Bama to identify unique marker genes their corresponding transcriptomic profiles diverse various organs, including subcutaneous fat, visceral psoas major muscle, liver, spleen, lung, kidney....