A5021586374- Cancer-related molecular mechanisms research
- Protein Structure and Dynamics
- Medicinal Plant Pharmacodynamics Research
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- Genomics and Phylogenetic Studies
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- Machine Learning in Bioinformatics
- Colorectal Cancer Screening and Detection
- Computational Drug Discovery Methods
- Cancer-related gene regulation
- Radiomics and Machine Learning in Medical Imaging
- Antimicrobial Peptides and Activities
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- melanin and skin pigmentation
- S100 Proteins and Annexins
- Renal and related cancers
- Cancer Research and Treatments
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Tryptophan and brain disorders
Chengdu University
2025
Inner Mongolia People's Hospital
2017-2024
Institute of Medicinal Plant Development
2016-2024
Shanghai Children's Hospital
2012-2024
Shanghai Jiao Tong University
2013-2024
Sichuan University
2020
Sichuan Agricultural University
2019
Inner Mongolia University
2010-2012
Ministry of Education of the People's Republic of China
2012
University of Illinois Chicago
2005-2011
Objectives We aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis. Design performed 16S rRNA gene analysis mucosal samples from 81 cases including superficial gastritis (SG), atrophic (AG), intestinal metaplasia (IM) and cancer (GC) Xi’an, China, determine microbiome dysbiosis across GC. validated results in 126 Inner Mongolia, China. Results observed significant mucosa IM GC subjects, enrichment 21 depletion 10 bacterial taxa compared SG...
Background and AimsArtificial intelligence (AI)–assisted colonoscopy improves polyp detection characterization in colonoscopy. However, data from large-scale multicenter randomized controlled trials (RCT) an asymptomatic population are lacking.MethodsThis RCT aimed to compare AI-assisted with conventional for adenoma population. Asymptomatic subjects 45–75 years of age undergoing colorectal cancer screening by direct or fecal immunochemical test were recruited 6 referral centers Hong Kong,...
Carnobacterium maltaromaticum was found to be specifically depleted in female patients with colorectal cancer (CRC). Administration of C. reduces intestinal tumor formation two murine CRC models a female-specific manner. Estrogen increases the attachment and colonization via increasing colonic expression SLC3A2 that binds DD-CPase this bacterium. Metabolomic transcriptomic profiling unveils increased gut abundance vitamin D-related metabolites mucosal activation D receptor (VDR) signaling...
Musk, secreted by the musk gland of adult male musk-secreting mammals, holds significant pharmaceutical and cosmetic potential. However, understanding molecular mechanisms secretion remains limited, largely due to lack comprehensive multiomics analyses available platforms for relevant species, such as muskrat (Ondatra zibethicus Linnaeus) Chinese forest deer (Moschus berezovskii Flerov). We generated chromosome-level genome assemblies 2 species Flerov), along with 168 transcriptomes from...
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. It more prevalent in men than women. Related to this, recent genetic studies have revealed a causal role for androgen receptor (AR) hepatocarcinogenesis, but underlying molecular mechanism remains unclear. Here, we used genome-wide location and functional analyses identify critical mediator of AR signaling — cell cycle–related kinase (CCRK) that drives hepatocarcinogenesis via pathway dependent on β-catenin T factor...
Abstract Male musk deer secrete from the gland located between their naval and genitals. Unmated male forest generate a greater amount of than mated males, potentially allowing them to attract number females. In this study, we used gas chromatography mass spectrometry (GC/MS) explore chemical composition pods captive unmated sexually mature Chinese next-generation sequencing intensively survey bacterial communities within them. Analysis showed that males have more muscone cholesterol....
<h3>Objective</h3> Using genome-wide promoter methylation assay, B cell CLL/lymphoma 6 member <i>(BCL6B)</i> was found to be preferentially methylated in cancer. A study undertaken examine the epigenetic regulation, biological function and clinical significance of <i>BCL6B</i> gastric cancer (GC). <h3>Methods</h3> evaluated by combined bisulfite restriction analysis sequencing. The functions BCL6B were determined viability, colony formation, flow cytometry vivo tumorigenicity assays....
Abstract The paired box 5 ( PAX5 ) is a member of PAX transcription factors family involved in the regulation embryonic development. However, role carcinogenesis largely unclear. We identified that human cancer by methylation-sensitive representational difference analysis. examined biological functions and related molecular mechanisms hepatocellular carcinoma (HCC). Promoter methylation was evaluated methylation-specific polymerase chain reaction (PCR) bisulfite genomic sequencing (BGS)....
RING finger protein 135 has an important role in the occurrence of many cancers; however its regulation and function RNF135 hepatocellular carcinoma remains unknown. The promoter methylation status mRNA expression was evaluated by methylation-specific PCR, semi-quantitative RT-PCR, real-time quantitative PCR HCC tissues cell lines, further analyzed from Cancer Genome Atlas database. Wound healing assay, transwell migration, viability, colony formation assay were performed to investigate...
Background The Chinese forest musk deer, a solitary ungulate renowned for its secretion, is under extinction threat despite extensive use in traditional medicine and perfumery. demand significantly outstrips natural supply. Purpose This study aimed to explore the differences peptide profiles between cultured gland cells develop sustainable alternatives production aid conservation of deer. Materials Methods Musk samples from deer were collected analyzed using EASY-nLC 1000 system. Peptide...
Proteinases play critical roles in both intra and extracellular processes by binding cleaving their protein substrates. The cleavage can either be non-specific as part of degradation during catabolism or highly specific proteolytic cascades signal transduction events. Identification these targets is extremely challenging. Current computational approaches for predicting sites are very limited since they mainly represent the amino acid sequences patterns frequency matrices. In this work, we...
Animal gut microbiota begins to colonize after birth and is functionally indispensable for maintaining the health of host. It has been reported that gender age influence composition intestinal microbiome. However, effects on microorganism forest musk deer (FMD) remain unclear. The aim this study was establish relationship between structure fecal male female with age. Here, Illumina Miseq 300PE sequencing platform targeting 16S rRNA V3–V4 hypervariable region applied define FMD two groups,...
Forest musk deer is the most important animal for natural production, and composition changes periodically during secretion, accompanied by variation in com-position of deer-symbiotic bacteria. GC-MS 16S rRNA sequencing were conducted this study, dynamic to correlated chemical microbiota across secretion periods (prime period, vigorous period late period) investigated integrating its serum testosterone level different mating states. Results showed that level, changed with annual cycle...
AIM:To improve the outcome of orthotopic transplantation in a mouse model, we used an absorbable gelatin sponge (AGS) nude mice to establish implantation tumor model.
β654-thalassemia is a prominent Chinese subtype of b-thalassemia, representing 17% all cases β-thalassemia in China. The molecular mechanism underlying this involves the IVS-2-654 C→T mutation leading to aberrant β-globin RNA splicing. This results an additional 73-nucleotide exon between exons 2 and 3 leads severe thalassemia syndrome. Herein, we explored CRISPR/Cas9 genome editing approach eliminate 73- nucleotide by targeting both cryptic acceptor splice site at IVS-2-579 order correct...
BACKGROUND Schizophrenia is a psychiatric disorder characterized by chronic or recurrent symptoms. Lurasidone was licensed in China 2019 for the treatment of adult schizophrenia adults with maximum dose 80 mg/d. However, post-market surveillance (PMS) an adequate sample size required further validation drug’s safety profile and effectiveness. AIM To conduct PMS real-world clinical settings evaluate effectiveness lurasidone Chinese population. METHODS A prospective, multicenter, open-label,...
Abstract Motivation: Protein-lipid interactions play a central role in cellular signaling and membrane trafficking at the core of these are domains specialized lipid binding targeting. Considering importance domains, we have created MeTaDoR, comprehensive resource dedicated to targeting (MTDs). Result: MeTaDoR begins with brief introduction about all important MTDs including their subcellular localization structural features. Sequences known then provided two formats: standard Prosite format...
Annotation of the functional sites on surface a protein has been subject many studies. In this regard, search for attributes and features characterizing these is prime consequence. Here, we present an implementation kernel-based machine learning protocol identifying residues DNA-binding form interface with DNA. Sequence structural including solvent accessibility, local composition, net charge electrostatic potentials are examined. These then fed into Support Vector Machines (SVM) to predict...
Musk, secreted by adult male forest musk deer, is a kind of precious Chinese traditional medicine for treating cardiovascular, cerebrovascular and neurogenic diseases. However, lack knowledge on biosynthetic mechanism limited deer population have seriously hindered the development industry. Fortunately, given that muskrat has similar constituents pharmacological action with musk, an ideal model animal exploring mechanism. To explore in current study, transcriptomic analysis liver, kidney...
Forest musk deer (Moschus berezovskii, FMD) is an endangered artiodactyl species, male FMD produce musk.We have sequenced the whole genome of FMD, completed genomic assembly and annotation, performed bioinformatic analyses.Our results showed that microsatellites (SSRs) displayed nonrandomly distribution in regions, SSR abundances were much higher intronic intergenic regions compared to other regions.Tri-and hexanucleotide perfect (P) SSRs predominated coding (CDSs), whereas, tetra-and...
Mesoderm, derived from a new layer between epiblast and hypoblast during gastrulation, can differentiate into various tissues, including muscles, bones, kidneys, blood, the urogenital system. However, systematic elucidation of mesoderm characteristics specific markers remains challenge. This study aims to screen identify candidate genes important for development.Cells originating three germ layers were obtained by laser capture microdissection, followed microcellular RNA sequencing....
Muskrat musk is considered to be a potential substitute for traditional musk. However, little known about the similarity between muskrat and musk, whether it related age. In this study, (MR1, MR2, MR3) were from 1, 2, 3-year-old muskrats, respectively, white (WM) brown (BM) picked male forest deer. The results indicated that had higher WM than BM. Further research showed RM3 highest matched degree with WM. By significantly different metabolite analysis, we found 52 metabolites continue...