A5050552736- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Animal Behavior and Reproduction
- Physiological and biochemical adaptations
- Zebrafish Biomedical Research Applications
- Neural dynamics and brain function
- Robotic Locomotion and Control
- Muscle activation and electromyography studies
- Motor Control and Adaptation
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Biomimetic flight and propulsion mechanisms
- Plant and Biological Electrophysiology Studies
- Robotics and Automated Systems
- Conducting polymers and applications
- Advanced Vision and Imaging
- Crustacean biology and ecology
- Gaze Tracking and Assistive Technology
- Invertebrate Immune Response Mechanisms
- Visual perception and processing mechanisms
- Circadian rhythm and melatonin
- Human Pose and Action Recognition
- Fish biology, ecology, and behavior
- Bat Biology and Ecology Studies
- Neuroscience, Education and Cognitive Function
University of Washington
2016-2025
Seattle University
2020
Harvard University
2014-2016
Janelia Research Campus
2011-2014
University of Chicago
2009-2011
Howard Hughes Medical Institute
2011
University of Buenos Aires
2009
University of Montana
2008
Swarthmore College
2006
Quantifying movement is critical for understanding animal behavior. Advances in computer vision now enable markerless tracking from 2D video, but most animals move 3D. Here, we introduce Anipose, an open-source toolkit robust 3D pose estimation. Anipose built on the method DeepLabCut, so users can expand their existing experimental setups to obtain accurate tracking. It consists of four components: (1) a calibration module, (2) filters resolve errors, (3) triangulation module that integrates...
Drosophila melanogaster is an established model for neuroscience research with relevance in biology and medicine. Until recently, on the brain was hindered by lack of a complete uniform nomenclature. Recognizing this, Ito et al., 2014Ito K. Shinomiya M. Armstrong D.J. Boyan G. Hartenstein V. Harzsch S. Heisenberg Homberg U. Jenett A. al.A Systematic Nomenclature Insect Brain.Neuron. 2014; 81: 755-765Abstract Full Text PDF PubMed Scopus (329) Google Scholar produced authoritative nomenclature...
In most complex nervous systems there is a clear anatomical separation between the nerve cord, which contains of final motor outputs necessary for behaviour, and brain. insects, neck connective both physical information bottleneck connecting brain ventral cord (VNC, spinal analogue) comprises diverse populations descending (DN), ascending (AN) sensory neurons, are crucial sensorimotor signalling control. Integrating three separate EM datasets, we now provide complete connectomic description...
To move the body, brain must precisely coordinate patterns of activity among diverse populations motor neurons. Here, we use in vivo calcium imaging, electrophysiology, and behavior to understand how genetically-identified neurons control flexion fruit fly tibia. We find that leg exhibit a coordinated gradient anatomical, physiological, functional properties. Large, fast high force, ballistic movements while small, slow low postural movements. Intermediate fall between these two extremes....
At the cellular level, α-tubulin acetylation alters structure of microtubules to render them mechanically resistant compressive forces. How this biochemical property microtubule relates mechanosensation remains unknown, although prior studies have shown that influences touch perception. Here, we identify major Drosophila acetylase (dTAT) and show it plays key roles in several forms mechanosensation. dTAT is highly expressed larval peripheral nervous system (PNS), but largely dispensable for...
Proprioception, the sense of self-movement and position, is mediated by mechanosensory neurons that detect diverse features body kinematics. Although proprioceptive feedback crucial for accurate motor control, little known about how downstream circuits transform limb sensory information to guide output. Here we investigate neural in Drosophila process from fly leg. We identify three cell types distinct developmental lineages are positioned receive input proprioceptor subtypes encoding tibia...
Animal movement is controlled by motor neurons (MNs), which project out of the central nervous system to activate muscles. MN activity coordinated complex premotor networks that allow individual muscles contribute many different behaviors. Here, we use connectomics analyze wiring logic circuits controlling
A bstract Quantifying movement is critical for understanding animal behavior. Advances in computer vision now enable markerless tracking from 2D video, but most animals live and move 3D. Here, we introduce Anipose, a Python toolkit robust 3D pose estimation. Anipose built on the popular method DeepLabCut, so users can easily expand their existing experimental setups to obtain accurate tracking. It consists of four components: (1) calibration module, (2) filters resolve errors, (3)...
Summary Like the vertebrate spinal cord, insect ventral nerve cord (VNC) mediates limb sensation and motor control. Here, we apply automated tools for electron microscopy volume alignment, neuron segmentation, synapse prediction toward creating a connectome of an adult female Drosophila VNC. To interpret connectome, it is crucial to know its relationship with rest body. We therefore mapped muscle targets leg wing neurons in by comparing their morphology genetic driver lines, dye fills, X-ray...
Abstract Somatosensory neurons provide the nervous system with information about mechanical forces originating inside and outside body. Here, we use connectomics from electron microscopy to reconstruct analyze neural circuits downstream of largest somatosensory organ in Drosophila leg, femoral chordotonal (FeCO). The FeCO has been proposed support both proprioceptive sensing fly’s femur-tibia joint exteroceptive substrate vibrations, but it was unknown which sensory central contribute each...