A5077025313- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neurobiology and Insect Physiology Research
- Sleep and Wakefulness Research
- Advanced Memory and Neural Computing
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital Heart Disease Studies
- Neuroscience of respiration and sleep
- Animal Behavior and Reproduction
- Circadian rhythm and melatonin
- Ion Channels and Receptors
- Macrophage Migration Inhibitory Factor
- Coronary Artery Anomalies
- Apelin-related biomedical research
- Plant Molecular Biology Research
- Cardiac electrophysiology and arrhythmias
- Photoreceptor and optogenetics research
- Developmental Biology and Gene Regulation
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Adenosine and Purinergic Signaling
- Zebrafish Biomedical Research Applications
- MicroRNA in disease regulation
- Congenital heart defects research
Johns Hopkins University
2018-2024
Janelia Research Campus
2024
Helix (United States)
2024
McGill University Health Centre
2014-2022
Montreal General Hospital
2017-2022
State University of New York
2020
McGill University
2018-2020
Johns Hopkins Medicine
2020
Montreal Neurological Institute and Hospital
2018
University of Pittsburgh
2018
The architectures of dendritic trees are crucial for the wiring and function neuronal circuits because they determine coverage receptive territories, as well nature strength sensory or synaptic inputs. Here, we describe a cell-intrinsic pathway sculpting arborization (da) neurons in Drosophila that requires Longitudinals Lacking (Lola), BTB/POZ transcription factor, its control F-actin cytoskeleton through Spire (Spir), an actin nucleation protein. Loss Lola from da reduced overall length...
Long-term synaptic plasticity is widely believed to underlie learning and memory in the brain. Whether primarily expressed pre- or postsynaptically has been subject of considerable debate for many decades. More recently, it generally agreed that locus depends on a number factors, such as developmental stage, induction protocol, synapse type. Since presynaptic expression alters not just gain but also short-term dynamics synapse, whereas postsynaptic only modifies gain, fundamental...
Spontaneous bursts of electrical activity in the developing auditory system arise within cochlea before hearing onset and propagate through future sound-processing circuits brain to promote maturation neurons. Studies isolated cochleae revealed that this intrinsically generated is initiated by ATP release from inner supporting cells (ISCs), resulting activation purinergic autoreceptors, K + efflux, subsequent depolarization hair cells. However, it unknown when emerges or whether different...
How the brain controls need and acquisition of recovery sleep after prolonged wakefulness is an important issue in research. The monoamines serotonin dopamine are key regulators mammals Drosophila . We found that enzyme arylalkylamine N-acetyltransferase 1 (AANAT1) expressed by astrocytes specific subsets neurons adult brain. AANAT1 acetylates inactivates them, we limited accumulation upon deprivation (SD). Loss from astrocytes, but not neurons, caused flies to increase their daytime...
Nuclear factor-kappaB (NF-κB) is activated in neural progenitor cells the developing murine cerebral cortex during neurogenic phase, when it acts to prevent premature neuronal differentiation. Here we show that NF-κB activation continues mouse neocortical neurogenic-to-gliogenic switch. Blockade of endogenous activity gliogenesis leads formation supernumerary committed gliogenic progenitors and glial cell Conversely, forced transition causes delayed commitment decreased astroglial gene...
A plethora of experimental studies have shown that long-term synaptic plasticity can be expressed pre- or postsynaptically depending on a range factors such as developmental stage, synapse type, and activity patterns. The functional consequences this diversity are not clear, although it is understood whereas postsynaptic expression predominantly affects response amplitude, presynaptic alters both amplitude short-term dynamics. In most models neuronal learning, implemented changes in...
Hedgehog (Hh) proteins are secreted molecules essential for tissue development in vertebrates and invertebrates. Hh reception via the 12-pass transmembrane protein Patched (Ptc) elicits intracellular signaling through Smoothened (Smo). binding to Ptc is also proposed sequester ligand, limiting its spatial range of activity. In Drosophila, Interference hedgehog (Ihog) Brother ihog (Boi) two conserved redundant that pathway activation. How Ihog Boi activate response remains unknown; each can...
Sphingolipids have been implicated in mammalian placental development and function, but their regulation the placenta remains unclear. Herein we report that alkaline ceramidase 2 (ACER2) plays a key role sustaining integrity of vasculature by regulating homeostasis sphingolipids mice. The mouse gene (Acer2) is highly expressed between embryonic day (E) 9.5 E12.5. Acer2 deficiency both mother fetus decreases levels sphingolipids, including sphingoid bases (sphingosine dihydrosphingosine)...
Summary Characteristic features of sleep are conserved among species [1], and from humans to insects is influenced by neural circuits involving monoamines such as serotonin dopamine [2]. Glial cells have been increasingly implicated in mechanisms baseline homeostatic regulation mammals flies [3–11], but it remains unknown whether how glia might influence monoaminergic control sleep. Sleep regulated circadian rhythms a drive compensate for prolonged wakefulness, growing evidence suggests that...
Abstract A plethora of experimental studies have shown that long-term plasticity can be expressed pre- or postsynaptically depending on a range factors such as developmental stage, synapse type, and activity patterns. The functional consequences this diversity are unknown. However, in models neuronal learning, synaptic is implemented changes connective weights. Whereas postsynaptic expression predominantly affects response amplitude, presynaptic alters both amplitude short-term dynamics. In...
Abstract A plethora of experimental studies have shown that long-term synaptic plasticity can be expressed pre- or postsynaptically depending on a range factors such as developmental stage, synapse type, and activity patterns. The functional consequences this diversity are not clear, although it is understood whereas postsynaptic expression predominantly affects response amplitude, presynaptic alters both amplitude short-term dynamics. In most models neuronal learning, implemented changes in...
ABSTRACT Spontaneous bursts of electrical activity in the developing auditory system arise within cochlea prior to hearing onset and propagate through future sound processing circuits brain promote maturation neurons. Studies isolated cochleae revealed that this intrinsically generated is initiated by ATP release from inner supporting cells (ISCs), resulting activation purinergic autoreceptors, K + efflux subsequent depolarization hair (IHCs). However, little known about when emerges or...
The architectures of dendritic trees are crucial for the wiring and function neuronal circuits because they determine coverage receptive territories, as well nature strength sensory or synaptic inputs. Here, we describe a cell-intrinsic pathway sculpting arborization (da) neurons in Drosophila that requires Longitudinals Lacking (Lola), BTB/POZ transcription factor, its control F-actin cytoskeleton through Spire (Spir), an actin nucleation protein. Loss Lola from da reduced overall length...
Introduction: Transposition of the great arteries (TGA) is one most common neonatal heart defects with a prevalence 0.2 per 1,000 live births. Although some studies have suggested laterality genes and environmental factors are involved, pathogenesis this outflow defect still unclear. The majority TGA sporadic, arguing for polygenic etiology. Methods: Whole exome sequencing (WES) analysis was conducted on 104 unrelated subjects isolated or complex TGA. Variants in 20 human mouse previously...