Alexandre Javier
A5045265975- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Genetics, Aging, and Longevity in Model Organisms
- Color perception and design
- Insect Utilization and Effects
- Olfactory and Sensory Function Studies
- Multisensory perception and integration
- Categorization, perception, and language
- Animal Behavior and Reproduction
- Insect Pheromone Research and Control
- Retinal Development and Disorders
- Physiological and biochemical adaptations
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Plant and Biological Electrophysiology Studies
- COVID-19 Clinical Research Studies
University of Cambridge
2020-2024
University College London
2018-2019
Nervous systems contain sensory neurons, local projection and motor neurons. To understand how these building blocks form whole circuits, we must distil broad classes into neuronal cell types describe their network connectivity. Using an electron micrograph dataset for entire Drosophila melanogaster brain, reconstruct the first complete inventory of olfactory projections connecting antennal lobe, insect analog mammalian bulb, to higher-order brain regions in adult animal brain. We then...
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Abstract The fruit fly Drosophila melanogaster combines surprisingly sophisticated behaviour with a highly tractable nervous system. A large part of the fly’s success as model organism in modern neuroscience stems from concentration collaboratively generated molecular genetic and digital resources. As presented our FlyWire companion paper 1 , this now includes first full brain connectome an adult animal. Here we report systematic hierarchical annotation ∼130,000-neuron including neuronal...
Abstract Animal behavior is principally expressed through neural control of muscles. Therefore understanding how the brain controls requires mapping neuronal circuits all way to motor neurons. We have previously established technology collect large-volume electron microscopy data sets tissue and fully reconstruct morphology neurons their chemical synaptic connections throughout volume. Using these tools we generated a dense wiring diagram, or connectome, for large portion Drosophila central...
Animal behavior is principally expressed through neural control of muscles. Therefore understanding how the brain controls requires mapping neuronal circuits all way to motor neurons. We have previously established technology collect large-volume electron microscopy data sets tissue and fully reconstruct morphology neurons their chemical synaptic connections throughout volume. Using these tools we generated a dense wiring diagram, or connectome, for large portion Drosophila central brain....
In most complex nervous systems there is a clear anatomical separation between the nerve cord, which contains of final motor outputs necessary for behaviour, and brain. insects, neck connective both physical information bottleneck connecting brain ventral cord (VNC, spinal analogue) comprises diverse populations descending (DN), ascending (AN) sensory neurons, are crucial sensorimotor signalling control. Integrating three separate EM datasets, we now provide complete connectomic description...
Abstract Nervous systems contain sensory neurons, local projection neurons and motor neurons. To understand how these building blocks form whole circuits, we must distil broad classes into neuronal cell types describe their network connectivity. Using an electron micrograph dataset for entire Drosophila melanogaster brain, reconstruct the first complete inventory of olfactory projections connecting antennal lobe, insect analogue mammalian bulb, to higher-order brain regions in adult animal...
Abstract The hemibrain connectome provides large scale connectivity and morphology information for the majority of central brain Drosophila melanogaster . Using this data set, we provide a complete description olfactory system, covering all first, second lateral horn-associated third-order neurons. We develop generally applicable strategy to extract flow layered organisation from graphs, mapping input descending interneurons. This identifies range motifs including highly lateralised circuits...
Animal behavior is principally expressed through neural control of muscles. Therefore understanding how the brain controls requires mapping neuronal circuits all way to motor neurons. We have previously established technology collect large-volume electron microscopy data sets tissue and fully reconstruct morphology neurons their chemical synaptic connections throughout volume. Using these tools we generated a dense wiring diagram, or connectome, for large portion Drosophila central brain....
Abstract We used the Land Colour Mondrian experiments in a Bayesian context to test degree which subjects vary categorizing colour of different patches, when each patch is made reflect light identical wavelength‐energy composition. The brain uses ratio‐taking mechanism determine ratio every waveband reflected from surface and its surrounds. Our (Bayesian) hypothesis was that this similar all humans therefore leads constant categorization colours differs little between them. similarly...
In the work reported here, we used Land Color Mondrian experiments to test degree which subjects vary in their perception of color categories. Twenty different ethnic and cultural backgrounds, for all but one whom English was not primary language, viewed 8 patches two displays; each patch, when viewed, made reflect identical ratios long, middle short wave light. Subjects were asked match patch with that Munsell chip coming closest without using language. Overall, there no variability...