A5089344463- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Olfactory and Sensory Function Studies
- Physiological and biochemical adaptations
- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Microbial Metabolic Engineering and Bioproduction
- Bioinformatics and Genomic Networks
- Plant and Biological Electrophysiology Studies
- Animal Behavior and Reproduction
- Gene Regulatory Network Analysis
- Plant Molecular Biology Research
MRC Laboratory of Molecular Biology
2020-2024
University of Cambridge
2018-2020
Institute of Neurobiology
2020
MRC Cancer Unit
2018
Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) well positioned for developing and testing such approach due to its conserved architecture, recently completed dense connectome, extensive prior experimental studies of roles learning, memory, activity regulation. Here, we identify new components MB circuit Drosophila, including visual input output neurons (MBONs) with...
Accurately predicting an outcome requires that animals learn supporting and conflicting evidence from sequential experience. In mammals invertebrates, learned fear responses can be suppressed by experiencing predictive cues without punishment, a process called memory extinction. Here, we show extinction of aversive memories in Drosophila specific dopaminergic neurons, which indicate omission punishment is remembered as positive Functional imaging revealed co-existence intracellular calcium...
Abstract The fruit fly Drosophila melanogaster combines surprisingly sophisticated behaviour with a highly tractable nervous system. A large part of the fly’s success as model organism in modern neuroscience stems from concentration collaboratively generated molecular genetic and digital resources. As presented our FlyWire companion paper 1 , this now includes first full brain connectome an adult animal. Here we report systematic hierarchical annotation ∼130,000-neuron including neuronal...
Animals exhibit innate and learned preferences for temperature humidity—conditions critical their survival reproduction. Leveraging a whole-brain electron microscopy volume, we studied the adult Drosophila melanogaster circuitry associated with antennal thermo- hygrosensory neurons. We have identified two new target glomeruli in lobe, addition to five known ones, ventroposterior projection neurons (VP PNs) that relay information higher brain centers, including mushroom body lateral horn,...
Different types of Drosophila dopaminergic neurons (DANs) reinforce memories unique valence and provide state-dependent motivational control [1]. Prior studies suggest that the compartment architecture mushroom body (MB) is relevant resolution for distinct DAN functions [2, 3]. Here we used a recent electron microscope volume fly brain [4] to reconstruct fine anatomy individual DANs within three MB compartments. We find 20 γ5 compartment, at least some which reward teaching signals, can be...
Abstract Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) well positioned for developing and testing such approach due to its conserved architecture, recently completed dense connectome, extensive prior experimental studies of roles learning, memory activity regulation. Here we identify new components MB circuit Drosophila , including visual input output neurons...
SUMMARY Animals exhibit innate and learned preferences for temperature humidity – conditions critical their survival reproduction. Here, we leveraged a whole adult brain electron microscopy volume to study the circuitry associated with antennal thermosensory hygrosensory neurons, which target specific ventroposterior (VP) glomeruli in Drosophila melanogaster lobe. We have identified two new VP glomeruli, addition five known ones, projection neurons (VP PNs) that relay information higher...
We present a library of network motifs for the development complex and realistic biological models using BioModelAnalyzer, demonstrate their wider value by them to construct model cell cycle.
In the Drosophila olfactory system most odorants are encoded in antennal lobe a combinatory way, activating several glomerular circuits. However, of particular ecological role for fly through activation single specialized pathway. Comparative analyses densely reconstructed connectomes one broadly tuned glomerulus (DL5) and narrowly (DA2) gained detailed insight into variations synaptic circuitries glomeruli with different computational tasks. Our approach combined laser-branding interest...
Summary Different types of Drosophila dopaminergic neurons (DANs) reinforce memories unique valence and provide state-dependent motivational control [1]. Prior studies suggest that the compartment architecture mushroom body (MB) is relevant resolution for distinct DAN functions [2, 3]. Here we used a recent electron microscope volume fly brain [4] to reconstruct fine anatomy individual DANs within three MB compartments. We find 20 γ5 compartment, at least some which reward teaching signals,...
ABSTRACT In the Drosophila olfactory system most odorants are encoded in antennal lobe a combinatory way, activating several glomerular circuits. However, of particular ecological role for fly through activation single specialized pathway. Comparative analyses densely reconstructed connectomes one broadly tuned glomerulus (DL5) and narrowly (DA2) gained detailed insight into variations synaptic circuitries glomeruli with different computational tasks. Our approach combined laser-branding...
In the Drosophila olfactory system most odorants are encoded in antennal lobe a combinatory way, activating several glomerular circuits. However, of particular ecological role for fly through activation single specialized pathway. Comparative analyses densely reconstructed connectomes one broadly tuned glomerulus (DL5) and narrowly (DA2) gained detailed insight into variations synaptic circuitries glomeruli with different computational tasks. Our approach combined laser-branding interest...
ABSTRACT In an age where the volume of data regarding biological systems exceeds our ability to analyse it, many researchers are looking towards biology and computational modelling help unravel complexities gene protein regulatory networks. particular, use discrete allows generation signalling networks in absence full quantitative descriptions systems, which necessary for ordinary differential equation (ODE) models. order make such techniques more accessible mainstream researchers, tools as...