A5004313268- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neurobiology and Insect Physiology Research
- Visual perception and processing mechanisms
- Animal Behavior and Reproduction
- Insect and Arachnid Ecology and Behavior
- Memory and Neural Mechanisms
- Plant Molecular Biology Research
- Physiological and biochemical adaptations
- Attention Deficit Hyperactivity Disorder
- Circadian rhythm and melatonin
University of Oxford
2020-2024
Norwegian University of Science and Technology
2024
Wellcome Centre for Integrative Neuroimaging
2023
Different types of Drosophila dopaminergic neurons (DANs) reinforce memories unique valence and provide state-dependent motivational control [1]. Prior studies suggest that the compartment architecture mushroom body (MB) is relevant resolution for distinct DAN functions [2, 3]. Here we used a recent electron microscope volume fly brain [4] to reconstruct fine anatomy individual DANs within three MB compartments. We find 20 γ5 compartment, at least some which reward teaching signals, can be...
The claustrum is thought to be one of the most highly interconnected forebrain structures but its organizing principles have yet fully explored at level single neurons. Here, we investigated identity, connectivity, and activity identified neurons understand how structure's unique convergence input divergence output support binding information streams. We found that in communicate with each other across efferent projection-defined modules which were differentially innervated by sensory...
Resource-seeking behaviours are ordinarily constrained by physiological needs and threats of danger, the loss these controls is associated with pathological reward seeking1. Although dysfunction dopaminergic valuation system brain known to contribute towards unconstrained seeking2,3, underlying reasons for this behaviour unclear. Here we describe neural mechanisms that produce seeking despite adverse consequences in Drosophila melanogaster. Odours paired optogenetic activation a defined...
The claustrum is thought to be one of the most highly interconnected forebrain structures but its organizing principles have yet fully explored at level single neurons. Here, we investigated identity, connectivity, and activity identified neurons understand how structure’s unique convergence input divergence output support binding information streams. We found that in communicate with each other across efferent projection-defined modules which were differentially innervated by sensory...
The claustrum is thought to be one of the most highly interconnected forebrain structures but its organizing principles have yet fully explored at level single neurons. Here, we investigated identity, connectivity, and activity identified neurons understand how structure’s unique convergence input divergence output support binding information streams. We found that in communicate with each other across efferent projection-defined modules which were differentially innervated by sensory...
Summary Different types of Drosophila dopaminergic neurons (DANs) reinforce memories unique valence and provide state-dependent motivational control [1]. Prior studies suggest that the compartment architecture mushroom body (MB) is relevant resolution for distinct DAN functions [2, 3]. Here we used a recent electron microscope volume fly brain [4] to reconstruct fine anatomy individual DANs within three MB compartments. We find 20 γ5 compartment, at least some which reward teaching signals,...
The claustrum is thought to be one of the most highly interconnected forebrain structures but its organizing principles have yet fully explored at level single neurons. Here, we investigated identity, connectivity, and activity identified neurons understand how structure’s unique convergence input divergence output support binding information streams. We found that in communicate with each other across efferent projection-defined modules which were differentially innervated by sensory...
Abstract Using short-term memory (STM) requires that animals can distinguish memories of recent experience from those learned previously. In Drosophila the neuromodulator octopamine (OA) specifically affects STM through adrenergic-like receptors within neurons in Mushroom Body (MB) network. However, why OA preferentially impacts remains unclear. A fly brain connectome reveals two OA-VPM3 provide most input to MB Artificial activation during olfactory learning enhances and divert odor...