Tansy Yang
A5018755898- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Animal Behavior and Reproduction
- Plant and Biological Electrophysiology Studies
- Genetics, Aging, and Longevity in Model Organisms
- Neural dynamics and brain function
- Prenatal Substance Exposure Effects
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Invertebrate Immune Response Mechanisms
- Advanced Memory and Neural Computing
- CCD and CMOS Imaging Sensors
- Plant Molecular Biology Research
Janelia Research Campus
2020-2025
Howard Hughes Medical Institute
2020-2025
Helix (United States)
2020
University of Maryland, Baltimore
2016
Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) well positioned for developing and testing such approach due to its conserved architecture, recently completed dense connectome, extensive prior experimental studies of roles learning, memory, activity regulation. Here, we identify new components MB circuit Drosophila, including visual input output neurons (MBONs) with...
Abstract The neural circuits responsible for behavior remain largely unknown. Previous efforts have reconstructed the complete of small animals, with hundreds neurons, and selected larger animals. Here we (the FlyEM project at Janelia collaborators Google) summarize new methods present circuitry a large fraction brain much more complex animal, fruit fly Drosophila melanogaster . Improved include procedures to prepare, image, align, segment, find synapses, proofread such data sets; that...
Abstract Animal behavior is principally expressed through neural control of muscles. Therefore understanding how the brain controls requires mapping neuronal circuits all way to motor neurons. We have previously established technology collect large-volume electron microscopy data sets tissue and fully reconstruct morphology neurons their chemical synaptic connections throughout volume. Using these tools we generated a dense wiring diagram, or connectome, for large portion Drosophila central...
Vision provides animals with detailed information about their surroundings, conveying diverse features such as color, form, and movement across the visual scene. Computing these parallel spatial requires a large network of neurons, that in distant flies humans, regions comprise half brain's volume. These brain often reveal remarkable structure-function relationships, neurons organized along maps shapes directly relate to roles processing. To unravel stunning diversity complex system, careful...
Animal behavior is principally expressed through neural control of muscles. Therefore understanding how the brain controls requires mapping neuronal circuits all way to motor neurons. We have previously established technology collect large-volume electron microscopy data sets tissue and fully reconstruct morphology neurons their chemical synaptic connections throughout volume. Using these tools we generated a dense wiring diagram, or connectome, for large portion Drosophila central brain....
Abstract Vision provides animals with detailed information about their surroundings and conveys diverse features such as colour, form movement across the visual scene. Computing these parallel spatial requires a large network of neurons. Consequently, from flies to humans, regions in brain constitute half its volume. These often have marked structure–function relationships, neurons organized along maps shapes that directly relate roles processing. More than century anatomical studies...
Aggressive social interactions are used to compete for limited resources and regulated by complex sensory cues the organism's internal state. While both sexes exhibit aggression, its neuronal underpinnings understudied in females. Here, we identify a population of sexually dimorphic aIPg neurons adult Drosophila melanogaster central brain whose optogenetic activation increased, genetic inactivation reduced, female aggression. Analysis GAL4 lines identified an unbiased screen increased...
Abstract The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction brain fruit fly Drosophila melanogaster. Improved include procedures to prepare, image, align, segment, find synapses in, proofread such data sets. define cell types, refine computational compartments, provide an exhaustive atlas examples many them novel. detailed consisting neurons their chemical most central brain. make public simplify...
Abstract Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) well positioned for developing and testing such approach due to its conserved architecture, recently completed dense connectome, extensive prior experimental studies of roles learning, memory activity regulation. Here we identify new components MB circuit Drosophila , including visual input output neurons...
Animal behavior is principally expressed through neural control of muscles. Therefore understanding how the brain controls requires mapping neuronal circuits all way to motor neurons. We have previously established technology collect large-volume electron microscopy data sets tissue and fully reconstruct morphology neurons their chemical synaptic connections throughout volume. Using these tools we generated a dense wiring diagram, or connectome, for large portion Drosophila central brain....
Prenatal ethanol exposure can result in social deficits humans and animals, including altered interaction poor communication. Rats exposed to prenatally show reduced play fighting, a combination of prenatal neonatal whisker clipping further reduces fighting compared with alone. In this study, we explored whether expression hedonic ultrasonic vocalizations (USVs) correlated the number playful attacks by ethanol-exposed rats, rats subjected postnatal sensory deprivation or both control...
Choosing a mate is one of the most consequential decisions female will make during her lifetime. This particularly true for species in which females either repeatedly with same partner or infrequently but use sperm from single copulation to fertilize eggs over an extended period time. Drosophila melanogaster uses latter strategy. Here, we characterize neural circuitry that implements mating brain. A fly signals choice by opening vaginal plates allow courting male copulate 1,2 . Vaginal plate...
Abstract Aggressive social interactions are used to compete for limited resources and regulated by complex sensory cues the organism’s internal state. While both sexes exhibit aggression, its neuronal underpinnings understudied in females. Here, we describe a set of connected neurons adult Drosophila melanogaster central brain that drive female aggression. We identified population sexually dimorphic aIPg whose optogenetic activation increased, genetic inactivation reduced, Analysis GAL4...