A5039274074- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Cancer Mechanisms and Therapy
- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Plant and Biological Electrophysiology Studies
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- T-cell and B-cell Immunology
- Chromatin Remodeling and Cancer
- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Axon Guidance and Neuronal Signaling
- Growth Hormone and Insulin-like Growth Factors
- Mechanisms of cancer metastasis
- Muscle metabolism and nutrition
- American History and Culture
- RNA modifications and cancer
- Genetics, Aging, and Longevity in Model Organisms
- Asthma and respiratory diseases
- Exercise and Physiological Responses
- Mormonism, Religion, and History
- Cytomegalovirus and herpesvirus research
- Veterinary Equine Medical Research
University of Virginia
2019-2023
Purdue University West Lafayette
2021-2022
University of Florida
2021
Janelia Research Campus
2020
Howard Hughes Medical Institute
2020
Abstract The neural circuits responsible for behavior remain largely unknown. Previous efforts have reconstructed the complete of small animals, with hundreds neurons, and selected larger animals. Here we (the FlyEM project at Janelia collaborators Google) summarize new methods present circuitry a large fraction brain much more complex animal, fruit fly Drosophila melanogaster . Improved include procedures to prepare, image, align, segment, find synapses, proofread such data sets; that...
Abstract The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction brain fruit fly Drosophila melanogaster. Improved include procedures to prepare, image, align, segment, find synapses in, proofread such data sets. define cell types, refine computational compartments, provide an exhaustive atlas examples many them novel. detailed consisting neurons their chemical most central brain. make public simplify...
Human rhinoviruses cause the common cold and exacerbate chronic respiratory diseases. Although infection elicits neutralizing antibodies, these do not persist or cross-protect across multiple rhinovirus strains. To analyze rhinovirus-specific B cell responses in humans, we developed techniques using intact RV-A16 RV-A39 for high-throughput high-dimensional single-cell analysis, with parallel assessment of antibody isotypes an experimental model. Our approach identified T-bet+ cells binding...
Abstract WNT signaling represents an attractive target for cancer therapy due to its widespread oncogenic role. However, the molecular players involved in and impact of their perturbation remain unknown numerous recalcitrant cancers. Here, we characterize pathway activity small cell lung (SCLC) determine functional role using genetically engineered mouse models. β-Catenin, a master mediator canonical signaling, was dispensable SCLC development, transcriptional program largely silenced during...
Abstract Small cell lung cancer (SCLC) is aggressive with limited therapeutic options. Despite recent advances in targeted therapies and immunotherapies, therapy resistance a recurring issue, which might be partly due to tumor plasticity, change fate. Nonetheless, the mechanisms underlying plasticity immune evasion SCLC remain elusive. CRACD, capping protein inhibitor that promotes actin polymerization, frequently inactivated SCLC. Cracd knockout (KO) transforms preneoplastic cells into...
<div>Abstract<p>WNT signaling represents an attractive target for cancer therapy due to its widespread oncogenic role. However, the molecular players involved in WNT and impact of their perturbation remain unknown numerous recalcitrant cancers. Here, we characterize pathway activity small cell lung (SCLC) determine functional role using genetically engineered mouse models. β-Catenin, a master mediator canonical signaling, was dispensable SCLC development, transcriptional program...
Supplementary Data from WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents Therapeutically Actionable Vulnerability in Small Cell Lung Cancer
Supplementary Data from WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents Therapeutically Actionable Vulnerability in Small Cell Lung Cancer
Supplementary Data from WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents Therapeutically Actionable Vulnerability in Small Cell Lung Cancer
Supplementary Data from WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents Therapeutically Actionable Vulnerability in Small Cell Lung Cancer
Supplementary Data from WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents Therapeutically Actionable Vulnerability in Small Cell Lung Cancer
Supplementary Data from WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents Therapeutically Actionable Vulnerability in Small Cell Lung Cancer
Supplementary Figure from WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents Therapeutically Actionable Vulnerability in Small Cell Lung Cancer
Supplementary Data from WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents Therapeutically Actionable Vulnerability in Small Cell Lung Cancer
Supplementary Data from WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents Therapeutically Actionable Vulnerability in Small Cell Lung Cancer
Supplementary Data from WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents Therapeutically Actionable Vulnerability in Small Cell Lung Cancer
Supplementary Data from WNT5A–RHOA Signaling Is a Driver of Tumorigenesis and Represents Therapeutically Actionable Vulnerability in Small Cell Lung Cancer