A5073295974- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Cancer, Lipids, and Metabolism
- Nutrition, Genetics, and Disease
- Inflammatory Biomarkers in Disease Prognosis
- Thyroid Cancer Diagnosis and Treatment
- Iron Metabolism and Disorders
- Heavy metals in environment
- Renal function and acid-base balance
- Radioactivity and Radon Measurements
- Clusterin in disease pathology
- BRCA gene mutations in cancer
- Biomarkers in Disease Mechanisms
- Effects and risks of endocrine disrupting chemicals
- Epigenetics and DNA Methylation
- Anesthesia and Neurotoxicity Research
- Mercury impact and mitigation studies
- Birth, Development, and Health
- Air Quality and Health Impacts
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Thyroid Disorders and Treatments
- Health, Environment, Cognitive Aging
- Pharmacological Effects of Medicinal Plants
- Genetics, Aging, and Longevity in Model Organisms
Guangxi Medical University
2020-2024
Guangxi University of Science and Technology
2022-2024
Shaoxing People's Hospital
2024
University of Science and Technology
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Abstract Context Various risk factors have been associated with the of thyroid cancer in observational studies. However, causality is not clear given susceptibility confounding and reverse causation. Objective A 2-sample Mendelian randomization approach was used to estimate effect potential on risk. Methods Genetic instruments proxy 55 were identified by genome-wide association studies (GWAS). Associations these genetic variants estimated GWAS FinnGen Study (989 cases 217 803 controls)....
Abstract Metal elements are present in the human body, and their levels blood have important impacts on health. In this study, 2488 Chinese individuals were included a genome-wide association study of 21 serum metal levels, with approximately 179,000 East Asian bidirectional two-sample Mendelian randomization (MR) analysis, 628,000 Europeans MR analysis. We identified two single nucleotide polymorphisms (SNPs) rs35691438 rs671 that significantly associated copper (SCLs). The analysis...
Importance Genetic and lifestyle factors are related to thyroid cancer (TC). Whether a healthy is associated with TC could attenuate the influence of genetic variants in remains equivocal. Objectives To examine associations between genetics incident whether adherence modifies association TC. Design, Setting, Participants A prospective cohort study using UK Biobank data recruited 502 505 participants aged 40 69 years March 13, 2006, October 1, 2010. total 307 803 European descent were at...
Background: Exposure to heavy metals has been reported be associated with multiple diseases. However, direct associations and potential mechanisms of physical disability remain unclear. Objectives: We aimed quantify further explore the DNA methylation on genome scale. Methods: A cross-sectional study 4,391 older adults was conducted activities daily living (ADL) were identified using a 14-item scale questionnaire including basic instrumental assess presence (yes or no) rated dependence. Odds...
The causality between circulating proteins and thyroid cancer (TC) remains unclear. We employed five large-scale proteomic genome-wide association studies (GWASs) with up to 100,000 participants a TC meta-GWAS (n
The objective of this study was to explore changes in miRNA133 levels as a basis for clinical diagnostic markers patients with acute myocardial infarction (AMI). A total 100 chest pain patient cases admitted hospital from June 2021 December 2022 were used. involved the selection 50 patients: 25 unstable undetermined heart and healthy subjects included control group non-AMI patients. Meanwhile, AMI designated experimental group. Changes patients’ plasma analyzed expression using quantitative...
Magnesium is integral to many physiological processes, whereas variations in its levels, even within the normal range, can have critical implications for health. To explore broad clinical effects of varying serum magnesium we performed a two-sample Mendelian randomization and phenome-wide association study (MR-PheWAS) UK Biobank cohort. In total, MR-PheWAS analysis implicated causal role levels five disease groups six outcomes. addition, our indicated gender-specific nine groups/outcomes MR...
Abstract Few studies are available on associations between metal mixture exposures and disrupted thyroid hormone homeostasis. Here we aimed to explore the cross-sectional relationship of blood cells metals with Among 328 workers from manganese exposed healthy cohort (MEWHC), detected function parameters: stimulating (TSH), total triiodothyronine (TT3), free (FT3), tetraiodothyronine (TT4), (FT4) as well calculated sum activity peripheral deiodinases (G D ) thyroid's secretory capacity T )....
<title>Abstract</title> To investigate cross-sectional association between blood metal mixture and myocardial enzyme profile based on an occupational population. We determined creatine kinase (CK) kinase-MB (CK-MB), lactate dehydrogenase (LD), α‐hydroxybutyrate (α‐HBD) aspartate transaminase (AST) among participants from the manganese-exposed workers healthy cohort (n = 544). Levels of 22 metals in cells were using inductively coupled plasma mass spectrometry. Least absolute shrinkage...