A5006524322- COVID-19 Clinical Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Respiratory Support and Mechanisms
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Long-Term Effects of COVID-19
- Gut microbiota and health
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Diet and metabolism studies
- RNA modifications and cancer
- Dietary Effects on Health
- COVID-19 and Mental Health
- Mindfulness and Compassion Interventions
- Immune cells in cancer
- Antimicrobial Peptides and Activities
- Pancreatitis Pathology and Treatment
- Diabetes and associated disorders
- Vitamin C and Antioxidants Research
- Epigenetics and DNA Methylation
- Intraocular Surgery and Lenses
- Heme Oxygenase-1 and Carbon Monoxide
- RNA Research and Splicing
- Circular RNAs in diseases
Xiangya Hospital Central South University
2015-2024
Central South University
2015-2024
Lanzhou University
2024
Bridge University
2023
Eye Center
2020-2023
Jishou University
2023
The First People's Hospital of Changde
2023
Qianjiang Central Hospital
2023
Chongqing University
2023
Hunan Provincial Center for Disease Control and Prevention
2022
Abstract Neutrophil extracellular traps (NETs) facilitate the killing of pathogens. However, excessive NETs formation and poor degradation are associated with exacerbated immune responses tissue injury. In this study, we investigated role in lipopolysaccharide (LPS)-mediated acute lung injury (ALI) assessed use DNase I, for treatment ALI. Additionally, focused on controversial issue whether LPS directly induces release vitro . was detected murine ALI vivo increased markers,...
Alveolar epithelial cell damage is an important determinant of the severity acute lung injury/acute respiratory distress syndrome (ALI/ARDS). However, molecular mechanisms alveolar death during development ALI/ARDS remain unclear. In this study, we explore role miR-29a-3p in and its mechanism. Plasma samples were collected from healthy controls ARDS patients. Mice intratracheally instilled with lipopolysaccharide (LPS) to establish injury. N6-adenosine (m6A) quantification, RNA-binding...
Uncontrollable inflammation is a critical feature of gram-negative bacterial pneumonia-induced acute respiratory distress syndrome (ARDS). Both neutrophils and alveolar macrophages participate in inflammation, but how their interaction augments triggers ARDS unclear. The authors hypothesize that neutrophil extracellular traps (NETs), which are formed during NETosis, partly cause macrophage pyroptosis worsen the severity ARDS. first analysed whether NETs caspase-1 involved clinical cases...
Abstract Intermittent fasting (IF) is a promising paradigm for weight loss which has been shown to modulate the gut microbiota based on 16S rRNA gene amplicon sequencing. Here, 72 Chinese volunteers with wide range of body mass index (BMI) participated in three-week IF program during an average 3.67 kg accompanied improved clinical parameters was observed irrespective initial anthropometric and status. Fecal samples were collected before after intervention subjected shotgun metagenomic De...
The HARMONY study was a randomized, controlled trial examining the efficacy of an 8-week mindfulness-based stress reduction (MBSR) program for blood pressure (BP) lowering among unmedicated stage 1 hypertensive participants.Participants diagnosed with hypertension based on ambulatory BP were randomized to either immediate treatment MBSR 8 weeks or wait-list control. Primary outcome analysis evaluated whether change in awake and 24-hour from baseline week 12 significantly different between 2...
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a manifestation of systemic inflammation in the lungs, but factors that trigger ALI/ARDS are unclear. We hypothesized neutrophil extracellular traps (NETs) contribute to pathogenesis acid aspiration-induced ALI/ARDS.Analysis bronchial aspirates from ARDS patients showed NETs were significantly correlated with degree (r = -0.5846, p 0.0359). bronchoalveolar lavage fluid acid-aspiration mice higher (141.6 ± 23.08) at 3 h after...
Long non-coding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) is oriented in an direction to the protein-coding gene AFAP1 opposite strand. Previous studies showed that lncRNA AFAP1-AS1 was upregulated and acted as oncogene a variety of tumors. However, expression biological functions tongue squamous cell carcinoma (TSCC) are still unknown. The level measured 103 pairs human TSCC tissues corresponding adjacent normal mucous tissues. correlation between...
The role of NOD-like receptor protein 3 (NLRP3)-mediated macrophages pyroptosis in acute lung injury (ALI) is well-established. Quercetin (Que) a natural bioflavonoid compound with anti-inflammatory and antioxidative properties that reportedly inhibits the NLRP3 inflammasome sepsis-induced organ dysfunctions such as ALI. However, mechanism underlying inhibitory effect quercetin on activation remains unclear. In this study, we established an endotoxin-induced ALI mouse model vitro LPS...
ABSTRACT Background The 2019 novel coronavirus disease (COVID-19) emerged in Wuhan, Hubei province, China, and was characterized as pandemic by the World Health Organization. Diabetes mellitus is an established risk factor for poor clinical outcomes, but association of diabetes with prognosis COVID-19 have not been reported yet. Methods In this cohort study, we retrospectively reviewed 258 consecutive hospitalized patients or without at West Court Union Hospital Huazhong University Science...
Early identification of patients with severe coronavirus disease (COVID-19) at an increased risk progression may promote more individualized treatment schemes and optimize the use medical resources. This study is aimed investigating utility C-reactive protein to albumin (CRP/Alb) ratio for early stratification patients.We retrospectively reviewed 557 COVID-19 confirmed outcomes (discharged or deceased) admitted West Court Union Hospital, Wuhan, China, between January 29, 2020 April 8, 2020....
Abstract Background Acute respiratory distress syndrome (ARDS) is a neutrophil-associated disease. Delayed neutrophil apoptosis and increased levels of extracellular traps (NETs) have been described in ARDS. We aimed to investigate the relationship between these phenomena their potential as inflammation drivers. hypothesized that delayed might enhance NET formation Method Our research was carried out three aspects: clinical research, animal experiments, vitro experiments. First, we compared...
The pathogenesis of ventilator-induced lung injury (VILI) is associated with neutrophils. Neutrophils release neutrophil extracellular traps (NETs), which are composed DNA and granular proteins. However, the role NETs in VILI remains incompletely understood. Normal saline deoxyribonuclease (DNase) were used to study VILI. To further determine Toll-like receptor 4 (TLR4) NETosis, we evaluated NET formation TLR4 knockout mice wild-type that mechanically ventilated. Some measures markers...
Cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) near chromosome 9p21 have been associated with both atherosclerosis and artery calcification, but the underlying mechanisms remained largely unknown. Considering that CDKN2A/2B is a frequently reported site for DNA methylation, this study aimed to evaluate whether carotid calcification (CarAC) related methylation levels of in patients ischemic stroke. were measured 322 stroke using peripheral blood leukocytes. Methylation 36 CpG sites...
Elderly patients with coronavirus disease 2019 (COVID-19) are more likely to develop severe or critical pneumonia, a high fatality rate. To date, there is no model predict the severity of COVID-19 in elderly patients. In this study, who maintained non-severe condition and progressed during hospitalization were assigned groups, respectively. Based on admission data these two groups training cohort, albumin (odds ratio [OR] = 0.871, 95% confidence interval [CI]: 0.809 - 0.937, P < 0.001),...
Objective: To identify potential predictors for invasive and non-invasive mechanical ventilation in coronavirus disease 2019 (COVID-19) patients. Methods: This study retrospectively analyzes data of 516 patients with confirmed COVID-19, who were categorized into three groups based on which method was used during the hospitalization period. Results: Among cases 446 did not receive ventilation, 38 received (IMV) 32 (NIMV). The median age included 61 years old (interquartile range, 52–69). A...