A5082012532- Cardiac Health and Mental Health
- Menopause: Health Impacts and Treatments
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Estrogen and related hormone effects
- Coronary Interventions and Diagnostics
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
- Sex and Gender in Healthcare
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- Cardiac Structural Anomalies and Repair
- Smoking Behavior and Cessation
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Global Public Health Policies and Epidemiology
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Hormonal and reproductive studies
- Bone health and osteoporosis research
- Cancer Risks and Factors
- Cardiac Valve Diseases and Treatments
St. Michael's Hospital
2016-2025
University of Toronto
2016-2025
St Michaels Hospital
2009-2025
Burnaby Hospital
2023
St Michael’s Hospital
2021
Toronto Public Health
2012-2019
McMaster University
2019
Regional Medical Center
2018
University of Ottawa
2000-2016
University Health Network
2008-2016
INCE THE EARLY 1990S, STUDIES have reported prevalences of major depression between 17% and 27% in hospitalized patients with coronary artery disease (CAD). 1 Most also demonstrated that has a negative cardiac prognostic impact. 2,3 Only large randomized trial, the Enhancing Recovery Coronary Heart Disease (ENRICHD) study, 4 tried to determine whether treating could improve prognosis CAD patients.Although ENRICHD combination short-term individual cognitive behavior therapy (CBT) selective...
Background— Less than one-third of smokers hospitalized with an acute coronary syndrome (ACS) remain abstinent following discharge. We assessed whether varenicline, begun in-hospital, is efficacious for smoking cessation ACS. Methods and Results— conducted a multi-center, double-blind, randomized, placebo-controlled trial in which ACS were randomized to varenicline or placebo 12 weeks. All patients received low-intensity counseling. The primary end point was point-prevalence abstinence at 24...
Raloxifene, a selective estrogen receptor modulator, reduces risk of invasive breast cancer and osteoporosis, but the effect on for stroke venous thromboembolism in different patient subgroups is not established. The purpose this analysis was to evaluate raloxifene incidence all strokes, deaths, thromboembolic events according participant subgroups.This secondary end point an international, randomized, placebo-controlled clinical trial 10 101 postmenopausal women with or at increased...
The HARMONY study was a randomized, controlled trial examining the efficacy of an 8-week mindfulness-based stress reduction (MBSR) program for blood pressure (BP) lowering among unmedicated stage 1 hypertensive participants.Participants diagnosed with hypertension based on ambulatory BP were randomized to either immediate treatment MBSR 8 weeks or wait-list control. Primary outcome analysis evaluated whether change in awake and 24-hour from baseline week 12 significantly different between 2...
Whether viability imaging can impact long-term patient outcomes is uncertain. The PARR-2 study (Positron Emission Tomography and Recovery Following Revascularization) showed a nonsignificant trend toward improved at 1 year using an F-18-fluorodeoxyglucose positron emission tomography (PET)-assisted strategy in patients with suspected ischemic cardiomyopathy. When adhered to PET recommendations, outcome benefit was observed. Long-term of imaging-assisted management have not previously been...
Studies examining gender-based differences in outcomes of patients experiencing out-of-hospital cardiac arrest have demonstrated that, despite a higher likelihood return spontaneous circulation, women do not survival.Patients successfully resuscitated from enrolled the CCC trial (Trial Continuous or Interrupted Chest Compressions during CPR) were included. Hierarchical multivariable logistic regression models constructed to evaluate association between gender and survival after adjustment...
A multicentre prospective observational study (36 sites in 8 Canadian provinces), imbedded the CODE-MI trial, had clinical laboratories at these test 3 samples (normal, female 99th-percentile, and male 99th-percentile concentrations) monthly for 1 year on 67 instruments, producing 2142 results from 6 distinct troponin assays. Mean differences varied per assay with maximum values being ± 4, 8, 9 ng/L normal, sample, respectively. Using a pragmatic approach, combining all assays, analytic...
To provide updated guidelines for health care providers on the management of menopause in asymptomatic healthy women as well presenting with vasomotor or urogenital symptoms and considerations related to cardiovascular disease, breast cancer, urogynaecology, sexuality.Lifestyle interventions, prescription medications, complementary alternative therapies are presented according their efficacy treatment menopausal symptoms. Counselling therapeutic strategies sexuality concerns peri-...
An analytical benchmark for high-sensitivity cardiac troponin (hs-cTn) assays is to achieve a coefficient of variation (CV) ≤ 10.0 % at the 99th percentile upper reference limit (URL) used diagnosis myocardial infarction. Few prospective multicenter studies have evaluated assay imprecision and none determined precision female URL which lower than male all assays. Human serum plasma matrix samples were constructed yield hs-cTn concentrations near URLs Abbott, Beckman, Roche, Siemens These...
Contemporary methods of cardiovascular risk stratification are frequently inaccurate. Biomarkers such as high-sensitivity troponin I (hsTnI) have the potential to improve stratification. However, uncertainties exist regarding factors that determine hsTnI concentration. Our aim was investigate prevalence elevated in a large, contemporary Canadian cohort and describe effect comorbidities on We report large dataset 41,602 visits which measured routinely ambulatory outpatients. remeasured 28%...
Peripheral artery disease (PAD) is responsible for a significant burden of morbidity and mortality in Canada. Despite the publication recent guidelines outlining diagnosis management PAD, delivery care continues to be fragmented. With growing number medical surgical techniques available, Centres Excellence are natural evolution advancement patients living with PAD. This article outlines current challenges opportunities growth improve PAD
Cardiovascular disease (CVD) is an insidious threat that requires attention. Modifying risk factors can work toward preventing the current CVD epidemic. Elevated low-density lipoprotein cholesterol (LDL-c) a well-established and modifiable factor for cardiovascular, cerebrovascular, peripheral vascular diseases. Despite receiving maximally tolerated doses of statin therapy, many Canadian patients with do not achieve LDL-c targets. Additional lipid-lowering therapies, such as ezetimibe or...
Background and Purpose- Predictors of stroke transient ischemic attack (TIA) in patients with peripheral artery disease (PAD) are poorly understood. The primary aims this analysis were to (1) determine the incidence ischemic/hemorrhagic TIA symptomatic PAD, (2) identify predictors (3) compare rate ticagrelor- clopidogrel-treated patients. Methods- EUCLID (Examining Use Ticagrelor Peripheral Artery Disease) randomized 13 885 PAD receive monotherapy ticagrelor or clopidogrel for prevention...
<h3>BACKGROUND:</h3> Patients who continue to smoke after acute coronary syndrome are at increased risk of reinfarction and death. We previously found use varenicline increase abstinence 24 weeks syndrome; here we report results through 52 weeks. <h3>METHODS:</h3> The EVITA trial was a multicentre, double-blind, randomized, placebo-controlled for smoking cessation in patients admitted hospital with syndrome. Participants were randomly assigned (1:1) receive or placebo 12 weeks, conjunction...
Patients with peripheral artery disease (PAD) are at heightened risk of cardiovascular morbidity and mortality. We sought to evaluate the concomitant coronary (CAD) in patients symptomatic PAD versus without diagnosed CAD, whether ticagrelor was superior clopidogrel reducing that risk. The EUCLID trial randomized 13,885 antithrombotic monotherapy or clopidogrel. CAD defined as prior myocardial infarction (MI), percutaneous intervention (PCI), bypass graft (CABG) surgery. Median follow-up 30...
Twelve species of parasitic helminths, seven trematodes, four nematodes and one acanthocephalan are reported from various hosts. Creptotrema lynchi, a parasite Bufo marinus in Colombia, is described for the first time fish Brazil, parasitizing two different species. A list host species, measurements figures most parasites included with particular reference to tegument Bellumcorpus major recovered new host. The genus Zonocotyloides Padilha, 1978 considered synonym Zonocotyle combination:...