A5040772609- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Prostate Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Sexual function and dysfunction studies
- Chemical Synthesis and Analysis
- Lymphoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Neuropeptides and Animal Physiology
- Neuroendocrine Tumor Research Advances
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urinary Bladder and Prostate Research
- Estrogen and related hormone effects
- Hormonal and reproductive studies
- Cardiac Imaging and Diagnostics
- Enzyme function and inhibition
- Click Chemistry and Applications
- Advanced X-ray and CT Imaging
- Lung Cancer Treatments and Mutations
- Advanced MRI Techniques and Applications
University of British Columbia
2016-2025
Terry Fox Research Institute
2021-2025
BC Cancer Agency
2015-2024
Molecular Oncology (United States)
2019-2024
Western University
2003-2024
SA Technologies (United States)
2024
Centre Hospitalier de Beauvais
2024
Occupational Cancer Research Centre
2020-2023
Cancer Research Institute
2023
Canadian Centre for Applied Research in Cancer Control
2023
From the efforts of a number Canadian institutions and private industry collaborations, direct production 99mTc using medical cyclotrons has recently been advanced from 1970's academic exercise to commercial, economically viable solution for regional production. Using GE PETtrace 880 machines our team established preliminary saturated yields 2.7 GBq/μA, translating approximately 174 GBq after 6 hour irradiation. The is in process assessing accuracy reliability this value with goal optimizing...
Background:The diagnosis of malignant mesothelioma is a challenging medical problem. CT often cannot differentiate between benign diffuse pleural thickening and mesothelioma, while thoracentesis CT-guided biopsies are insensitive. We have assessed the value positron emission tomography (PET) with 2-fluoro-2-deoxy-D-glucose (FDG) in evaluation mesothelioma. Methods: Twenty-eight consecutive patients referred for suspected were evaluated by FDG-PET imaging. Measured attenuation correction was...
Abstract A new zwitterionic organotrifluoroborate is appended to three radiosynthons that afford undergo facile bioconjugation several clinically relevant peptides and one enzyme inhibitor. Molecularly complex bioconjugates are 18 F‐labeled in a single aqueous step rapid time (<15 min) without HPLC purification tracers good yields (>200 mCi, 20–40 %) at high specific activity (≥3 Ci/μmol) >98 % purity. PET imaging shows vivo stability tumor uptake.
A mild and selective photocatalytic C–H 18F-fluorination reaction has been developed that provides direct access to 18F-fluorinated amino acids. The biodistribution uptake of three 18F-labeled leucine analogues via LAT1 mediated transport in several cancer cell lines is reported. Positron emission tomography imaging mice bearing PC3 (prostate) or U87 (glioma) xenografts using 5-[18F]-fluorohomoleucine showed high tumor excellent visualization, highlighting the utility this strategy for rapid...
<sup>18</sup>F-DCFPyL (2-(3-{1-carboxy-5-[(6-<sup>18</sup>F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid), a prostate-specific membrane antigen–targeting radiotracer, has shown promise as prostate cancer imaging radiotracer. We evaluated the safety, sensitivity, and impact on patient management of in setting biochemical recurrence cancer. <b>Methods:</b> Subjects with after radical prostatectomy or curative-intent radiotherapy were included this prospective study. The...
We designed and evaluated a novel albumin-binder-conjugated 177Lu-PSMA-617 derivative, 177Lu-HTK01169, with an extended blood retention time to maximize the radiation dose delivered prostate tumors expressing prostate-specific membrane antigen (PSMA). PSMA-617 HTK01169 that contained N-[4-(p-iodophenyl)butanoyl]-Glu as albumin-binding motif were synthesized using solid-phase approach. Binding affinity PSMA was determined by in vitro competition-binding assay. 177Lu labeling performed acetate...
Tumor heterogeneity limits the efficacy and reliability of monospecific radiopharmaceuticals in prostate cancer diagnosis therapy. To overcome this limitation improve lesion detection sensitivity, we developed evaluated three bispecific radiotracers that can target both prostate-specific membrane antigen (PSMA) fibroblast activation protein (FAP), which are two key proteins overexpressed cancer. Three FAP-targeting ligands with various linker lengths were synthesized through multistep...
Radiotherapy (RT) and surgery are potential treatment options in patients with biochemical recurrence (BCR) following primary prostate cancer treatment. This study examines the value of prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT)-informed RT BCR treated without systemic therapy.This is a post-hoc subgroup analysis prospective clinical trial. Inclusion criteria were: histologically proven at initial curative-intent treatment, after...
OBJECTIVE To test the accuracy of predicting life‐expectancy (LE) among 19 raters, as accurate prediction LE in candidates for definitive therapy localized prostate cancer is crucial, and little known ability clinicians to predict LE. SUBJECTS AND METHODS We randomly selected case‐vignettes 50 patients treated with either radical prostatectomy (RP, 25) or external beam radiotherapy (EBRT, cancer, who survived > 10 years died earlier no evidence disease relapse. The median age at treatment...
Purpose Iodine-123 is a pure gamma emitter and has excellent characteristics for imaging with modern scintillation cameras. The goal of this study was to compare the performance I-123 I-131 as agents whole-body scanning in patients differentiated thyroid cancer undergoing ablation remnants after initial surgery. Methods Fourteen who had undergone near-total thyroidectomy serum thyroid-stimulating hormone levels greater than 40 mU/l underwent diagnostic 5 hours administration 48 56 MBq (1.3...
Phantom studies have shown improved lesion detection performance with time-of-flight (TOF) PET. In this study, we evaluate the benefit of fully 3-dimensional, TOF PET in clinical whole-body oncology using human observers to localize and detect lesions realistic patient anatomic backgrounds. Our hypothesis is that imaging achieve localization for clinically challenging tasks, a bigger impact large patients. <b>Methods:</b> One hundred normal <sup>18</sup>F-FDG uptake were chosen. Spheres...