A5014897253- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Medical Imaging and Pathology Studies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Regulation of Appetite and Obesity
- Cardiovascular Function and Risk Factors
- Particle accelerators and beam dynamics
- Pancreatic function and diabetes
- Crystallography and molecular interactions
- Receptor Mechanisms and Signaling
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Disease and Adiposity
- Superconducting Materials and Applications
- Genetics and Neurodevelopmental Disorders
- Radiation Detection and Scintillator Technologies
- Biochemical Analysis and Sensing Techniques
- Organometallic Complex Synthesis and Catalysis
- Adipose Tissue and Metabolism
- Amino Acid Enzymes and Metabolism
- Epigenetics and DNA Methylation
- Chemical Synthesis and Characterization
- Fluorine in Organic Chemistry
Lawson Health Research Institute
2015-2024
Western University
2010-2024
St Joseph's Health Care
2009-2024
Health Canada
2024
Cedars-Sinai Medical Center
2017-2020
University of California, Los Angeles
2020
Siemens Healthcare (United States)
2020
Fundación Kovacs
2016
BC Cancer Agency
2012
London Health Sciences Centre
2011
From the efforts of a number Canadian institutions and private industry collaborations, direct production 99mTc using medical cyclotrons has recently been advanced from 1970's academic exercise to commercial, economically viable solution for regional production. Using GE PETtrace 880 machines our team established preliminary saturated yields 2.7 GBq/μA, translating approximately 174 GBq after 6 hour irradiation. The is in process assessing accuracy reliability this value with goal optimizing...
<sup>99m</sup>Tc is currently produced by an aging fleet of nuclear reactors, which require enriched uranium and generate waste. We report the development a comprehensive solution to produce in sufficient quantities supply large urban area using single medical cyclotron. <b>Methods:</b> A new target system was designed for production. Target plates made tantalum were coated with layer <sup>100</sup>Mo electrophoretic deposition followed high-temperature sintering. The targets irradiated...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Convenient Method for the Preparation of Fluorous Tin Derivatives Labeling StrategyJason W. McIntee†, Chitra Sundararajan†, Amanda C. Donovan†, Michael S. Kovacs‡, Alfredo Capretta†, and John F. Valliant*†§View Author Information Department Chemistry, McMaster University, Hamilton, Ontario, Canada L8S 4M1, Lawson Health Research Institute, University Western London, Canada, Institute Applied Radiation Sciences (McIARS), 4M1* To whom...
The ghrelin receptor, also known as the growth hormone secretagogue receptor 1a (GHS-R1a), is a G-protein-coupled that differentially expressed in healthy tissue and several cancers, including prostate, testicular, ovarian. Selectively targeting using fluorine-18 tagged entities would allow localization visualization of expressing carcinomas PET imaging. endogenous ligand ghrelin, 28 amino acid peptide with 3.1 nM affinity, has poor vivo stability. Here we report on ghrelin(1–8) analogues...
Molecular imaging with positron emission tomography (PET) is an attractive platform for noninvasive detection and assessment of disease. The development a PET agent targeting the ghrelin receptor (growth hormone secretagogue type 1a or GHS-R1a) has potential to lead higher than normal expression GHS-R1a in diseases such as prostate, breast, ovarian cancer. To enable 18F radiopharmaceuticals, we have designed synthesized three series quinazolinone derivatives, resulting identification two...
Apoptosis is a feature of stroke and Alzheimer's disease (AD), yet there no accepted method to detect or follow apoptosis in the brain vivo. We developed bifunctional tracer [68Ga]Ga-TC3-OGDOTA containing cell-penetrating peptide separated from fluorescent Oregon Green 68Ga-bound labels by caspase-3 recognition DEVD. hypothesized that this design would allow accumulate apoptotic cells. In vitro, Ga-TC3-OGDOTA labeled neurons following exposure camptothecin, oxygen-glucose deprivation,...
We are combining nuclear medicine with molecular biology to establish a sensitive, quantitative, and tomographic method which detect gene expression in pancreatic islet cells vivo. Dual-isotope SPECT can be used image multiple events simultaneously, coregistration of CT images enables visualization reporter the correct anatomic context. have engineered cell lines for imaging SPECT/CT after transplantation under kidney capsule. <b>Methods:</b> INS-1 832/13 αTC1-6 were stably transfected...
Cardiac magnetic resonance imaging with repeat hypercapnia accurately detects myocardial oxygenation changes in a dog model of ischemic heart disease.
Myocardial blood flow (MBF) is the critical determinant of cardiac function. However, its response to increases in partial pressure arterial CO<sub>2</sub> (PaCO<sub>2</sub>), particularly with respect adenosine, not well characterized because challenges gas control and limited availability validated approaches ascertain MBF vivo. <b>Methods:</b> By prospectively independently controlling PaCO<sub>2</sub> combining it <sup>13</sup>N-ammonia PET measurements, we investigated whether a...
Background Despite advances, blood oxygen level-dependent (BOLD) cardiac MRI for myocardial perfusion is limited by inadequate spatial coverage, imaging speed, multiple breath holds, and artifacts, particularly at 3.0 T. Purpose To develop validate a robust, contrast agent-unenhanced, free-breathing three-dimensional (3D) approach reliably examining changes in between rest adenosine stress. Materials Methods A heart rate-independent, 3D T2 mapping technique T that can be completed within the...
Abstract A new fluorine‐containing azadibenzocyclooctyne (ADIBO‐F) was designed using a synthetically accessible pathway. The fluorine‐18 prosthetic group prepared from its toluenesulfonate precursor and isolated in 21–35 % radiochemical yield 30 minutes of synthetic time. ADIBO‐F has been incorporated into azide‐functionalized, cancer‐targeting peptides through strain‐promoted alkyne–azide cycloaddition with high yields purities. final products are novel peptide‐based positron emission...
<ns4:p><ns4:italic>Purpose</ns4:italic>: In diabetes, pancreatic beta cell mass declines significantly prior to onset of fasting hyperglycemia. This decline may be due endoplasmic reticulum (ER) stress, and the system L amino acid transporter LAT1 a biomarker this process. study, we used 5-(2-<ns4:sup>18</ns4:sup>F-fluoroethoxy)-L-tryptophan (<ns4:sup>18</ns4:sup>F-L-FEHTP) target as potential function in diabetes.</ns4:p><ns4:p> <ns4:italic>Procedures:</ns4:italic> Uptake...
<ns4:p><ns4:italic>Purpose</ns4:italic>: In diabetes, pancreatic beta cell mass declines significantly prior to onset of fasting hyperglycemia. This decline may be due endoplasmic reticulum (ER) stress, and the system L amino acid transporter LAT1 a biomarker this process. study, we used 5-(2-<ns4:sup>18</ns4:sup>F-fluoroethoxy)-L-tryptophan (<ns4:sup>18</ns4:sup>F-L-FEHTP) target as potential function in diabetes.</ns4:p><ns4:p> <ns4:italic>Procedures:</ns4:italic> Uptake...
Myocardial viability and quantification of regional myocardial blood flow (MBF) are important for the diagnosis heart disease. Positron emission tomography is current gold standard determining viability, but most positron-emitting perfusion tracers require an on-site cyclotron. Rubidium-82 ((82)Rb) a tracer that produced using generator. This study investigates (82)Rb-measured MBF in canine models stunned infarcted myocardium compared with selected measurements obtained concurrently...
Purpose Previous studies have shown the ability of rubidium-82 (82Rb) positron emission tomography (PET) imaging to quantitatively measure myocardial blood flow (MBF), many which are performed using two-dimensional (2D) imaging. Three-dimensional (3D) provides increased sensitivity and may result in decreased costs owing a reduction required injected activity radiotracer. This study compares 2D 3D 82Rb PET MBF results obtained same session. Methods perfusion was canines on GE Discovery LS...
Background: Early detection of Alzheimer’s disease (AD) pathology is a serious challenge for both diagnosis and clinical trials. The aspartyl protease, Cathepsin D (CatD), overexpressed in AD could be biomarker disease. We have previously designed unique contrast agent (CA) dual-optical magnetic resonance imaging the activity CatD class enzymes. Objective: To compare uptake retention novel, more sensitive, clinically-translatable 68 Ga PET tracer targeting 5XFAD mice non-Tg littermates....