A5067114921- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Advanced MRI Techniques and Applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Atomic and Subatomic Physics Research
- Cannabis and Cannabinoid Research
- Cancer, Hypoxia, and Metabolism
- Cardiac Imaging and Diagnostics
- Mechanical Behavior of Composites
- Forensic Toxicology and Drug Analysis
- Advanced Theoretical and Applied Studies in Material Sciences and Geometry
- Lanthanide and Transition Metal Complexes
- Advanced Neuroimaging Techniques and Applications
- Neuroscience of respiration and sleep
- Radiation Detection and Scintillator Technologies
- Prenatal Substance Exposure Effects
- Radiomics and Machine Learning in Medical Imaging
- Crystal structures of chemical compounds
- Medical Imaging and Pathology Studies
- Boron Compounds in Chemistry
- Receptor Mechanisms and Signaling
- Virus-based gene therapy research
- Chemical Synthesis and Analysis
- Parkinson's Disease Mechanisms and Treatments
Lawson Health Research Institute
2020-2024
Western University
2020-2024
Purdue University West Lafayette
2021-2024
St Joseph's Health Care
2022-2024
Health Canada
2024
University of Toronto
2010-2022
London Health Sciences Centre
2022
Ontario Shores Centre for Mental Health Sciences
2022
Western University of Health Sciences
2022
Manufacturing Institute
2021
Fatty acid amide hydrolase (FAAH) plays a key role in regulating the tone of endocannabinoid system. Radiotracers are required to image and quantify FAAH activity vivo. We have synthesized series potent inhibitors encompassing two classes N-alkyl-O-arylcarbamates radiolabeled eight them with carbon-11. The [11C-carbonyl]-radiotracers were evaluated vitro ex vivo rats as potential imaging agents for positron emission tomography (PET). Both sets [11C]O-arylcarbamates showed good excellent...
Technetium tricarbonyl chemistry has been a subject of interest in radiopharmaceutical development over the past decade. Despite extensive work done on developing chelates for Tc(I), rigorous investigation impact changing donor groups and labeling conditions radiochemical yields and/or distribution lacking. This information is crucially important if these platforms are going to be used develop molecular imaging probes. Previous studies coordination {M(CO)3}+ core have established alkylamine,...
Fatty acid amide hydrolase (FAAH), the enzyme responsible for terminating signaling by endocannabinoid anandamide, plays an important role in system, and FAAH inhibitors are attractive drugs pain, addiction, neurological disorders. The synthesis, radiosynthesis, evaluation, vitro ex vivo rat, of (18)F-radiotracer designed to image using positron emission tomography (PET) is described. Fluorine-18 labelled 3-(4,5-dihydrooxazol-2-yl)phenyl (5-fluoropentyl)carbamate, [(18)F]5, was synthesized...
Abstract Addition of thiosemicarbazide, 4‐allylthiosemicarbazide, and 4‐phenylthiosemicarbazide to (formylphenyl)boronic acids affords a series thiosemicarbazones containing boronic acids. 2‐formylphenylboronic acid the thiosemicarbazides gave corresponding cyclic 2,3,1‐benzodiazaborines. All new compounds have been investigated for potential antifungal activity.
Every year billions of dollars are spent on research grants to produce new knowledge in universities. However, as may also affect other funding, the effects financial resources production remain unclear. To uncover how production, we study spending itself. Utilizing legal constraints university from an endowment develop instrumental variables approach. Our approach instruments for with time‐series variation stock prices interacted cross‐sectional initial market values universities United...
Major depressive disorder (MDD) is a debilitating mental illness that has been linked to increases in markers of inflammation, as well changes brain functional and structural connectivity, particularly between the insula subgenual anterior cingulate cortex (sgACC). In this study, we directly related inflammation dysconnectivity treatment-resistant MDD by concurrently measuring following: microglial activity with [18F]N-2-(fluoroethoxyl)benzyl-N-(4phenoxypyridin-3-yl)acetamide ([18F]FEPPA)...
Stem cell-based therapies have demonstrated significant potential in clinical applications for many debilitating diseases. The ability to non-invasively and dynamically track the location viability of stem cells post administration could provide important information on individual patient response and/or side effects. Multi-modal cell tracking provides complementary that can offset limitations a single imaging modality yield more comprehensive picture fate. In this study, mesenchymal (MSCs)...
Clinical diagnosis of frontotemporal dementia (FTD) remains a challenge due to the overlap symptoms among FTD subtypes and with other psychiatric disorders. Perfusion imaging by arterial spin labeling (ASL) is promising non-invasive alternative established PET techniques; however, its sensitivity parameters can hinder ability detect perfusion abnormalities. This study evaluated similarity regional hypoperfusion patterns detected ASL relative gold standard for perfusion, radiolabeled water...
The gold standard for imaging the cerebral metabolic rate of oxygen (CMRO<sub>2</sub>) is PET; however, it an invasive and complex procedure that also requires correction recirculating <sup>15</sup>O-H<sub>2</sub>O blood-borne activity. We propose a noninvasive reference-based hybrid PET/MRI method uses functional MRI techniques to calibrate <sup>15</sup>O-O<sub>2</sub> PET data. Here, oxidative metabolism (PMROx) was validated in animal model by comparison PET-alone measurements....
Duchenne muscular dystrophy (DMD) is a neuromuscular disorder caused by dystrophin loss-notably within muscles and the central neurons system. DMD presents as cognitive weakness, progressive skeletal cardiac muscle degeneration until pre-mature death from or respiratory failure. Innovative therapies have improved life expectancy; however, this accompanied increased late-onset heart failure emergent degeneration. Thus, better assessment of dystrophic brain pathophysiology needed. Chronic...
Abstract Chimeric antigen receptor (CAR) cell therapies utilize CARs to redirect immune cells towards cancer expressing specific antigens like human epidermal growth factor 2 (HER2). Despite their potential, CAR T exhibit variable response rates and adverse effects in some patients. Non-invasive molecular imaging can aid predicting patient outcomes by tracking infused post-administration. CAR-T are typically autologous, increasing manufacturing complexity costs. An alternative approach...
In molecular imaging with dynamic PET, the binding and dissociation of a targeted tracer is characterized by kinetics modeling which requires arterial concentration to be measured accurately. Once in body radiolabeled parent may subjected hydrolysis, demethylation/dealkylation other biochemical processes, resulting production accumulation different metabolites blood can labeled same PET radionuclide as parent. Since these radio-metabolites cannot distinguished scanning from tracer, their...