A5003911693- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Organoboron and organosilicon chemistry
- Fungal Plant Pathogen Control
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- Metal complexes synthesis and properties
- Synthesis and biological activity
- Organometallic Compounds Synthesis and Characterization
- Chemical Synthesis and Analysis
- Crystal structures of chemical compounds
- Crystallography and molecular interactions
- Boron Compounds in Chemistry
- Organometallic Complex Synthesis and Catalysis
- Advanced Synthetic Organic Chemistry
- Coordination Chemistry and Organometallics
- Synthesis and Reactivity of Heterocycles
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Activity
- Chemical synthesis and alkaloids
- Synthetic Organic Chemistry Methods
- Environmental, Ecological, and Cultural Studies
- Medical Device Sterilization and Disinfection
- Insect Pest Control Strategies
- Earth Systems and Cosmic Evolution
Mount Allison University
2008-2020
Novel N2B heterocycles (1–5) are formed from the reaction of ethylenediamine derivatives with 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (2-HC(O)C6H4Bpin; pin = 1,2-O2C2Me4). X-ray diffraction studies have been carried out on four examples and show that reactions selective in giving isomer where least substituted amine coordinates to Lewis-acidic boron atom. Reaction 2-HC(O)C6H4Bpin diethylenetriamine gave a heterocycle (6) pendant primary group, which reacts further...
Abstract Addition of thiosemicarbazide, 4‐allylthiosemicarbazide, and 4‐phenylthiosemicarbazide to (formylphenyl)boronic acids affords a series thiosemicarbazones containing boronic acids. 2‐formylphenylboronic acid the thiosemicarbazides gave corresponding cyclic 2,3,1‐benzodiazaborines. All new compounds have been investigated for potential antifungal activity.
Eight new fluoro- and methoxy-substituted benzodiazaborines have been prepared by a simple condensation reaction in high-to-excellent yields. All compounds characterised several physical methods, including X-ray diffraction studies on three examples. were examined for antifungal activities against five species of potentially pathogenic fungi (Aspergillus niger, Aspergillus fumigatus, Rhizoctonia solani, Verticillium albo-atrum, dahliae). While substitution the aromatic group derived from...
Addition of 3-H 2 NC 6 H 4 Bpin (pin = 1,2-O C Me ) to a series aldehydes and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)acetophenone afforded the corresponding benzylideneamines in moderate high yields. Hydroboration these imines with catecholborane (HBcat, cat at room temperature gives, upon aqueous workup, borylamines. An X-ray diffraction study was carried out on imine 1h derived from 9-anthraldehyde Bpin. Crystals of1h were triclinic, 9.6793(4) Å, b 10.7397(4) c 11.5353(4) α...
Abstract Gravity and magnetism are implemented to change the morphology of zinc oxide nanorod sensors during synthesis. The effects gravity can translate into future application these nanorods through cost‐effective, environmentally friendly, easy‐to‐use biosensor technology with quickest available sensing. pave way toward detection both bacteria fungi present on surface high sensitivity. This ability sense microorganisms in a “non‐solution‐based” environment represents key step forward...
The addition of 4-ethyl-3-thiosemicarbazide to benzaldehyde and boronic acid containing derivatives afforded the corresponding thiosemicarbazones (1–3) or benzodiazaborines (4–6) depending on position within ring. All compounds have been characterized fully including an X-ray diffraction study methoxy-containing benzodiazaborine 6. Attempts coordinate 2 3 palladium(II) acetate were unsuccessful; however, non-boron-containing derivative 1 palladium complex 7 whose molecular structure was...
Condensation of salicylaldehyde (2-HOC 6 H 4 C(O)H) with 5-aminosalicylic acid (5-H 2 NC 3 -2-(OH)-CO H) afforded the Schiff base 2-HOC C(H)=NC -2-(OH)-5-CO (a). Similar reactivity 5-bromosalicylaldehyde was also observed to give 5-Br-2-HOC (b). Reaction these salicylaldehydes Pd(II), Cu(II), and Zn(II) salts gave corresponding bis(N-arylsalicylaldiminato)metal complexes (M = Pd (1), Cu (2), Zn (3)). The molecular structure compound a has been confirmed by an X-ray diffraction study....
A series of sulfur compounds has been prepared and tested against two kinds fungi: Aspergillus niger flavus. Results on various sulfone disulfides ester have led to the formulation a proposed mechanism for fungicidal behaviour that permits one anticipate which structures will be antifungal.
From a design principle described in an earlier paper, new series of substituted aryl methyl disulfides have been prepared and tested against Aspergillus niger flavus. Methyl p-nitrophenyl disulfide is more potent (by order magnitude) than the fungitoxic natural product (CH3SCH2S)2. With present rationale hand, one can anticipate which Polycarpamine effective antifungal agent.
A series of thiosulfonates have been prepared and tested against Aspergillus niger flavus. In general, the are moderate antifungal agents—more potent than corresponding inactive disulfides less very active fungitoxic disulfides. Apair show high selectivity, each killing only one kind fungus.
Abstract The addition of formylphenylboronic acid derivatives to thiourea and ethyl acetoacetate proceeds in the presence an additional Lewis catalyst give corresponding 3,4-dihydropyrimidin-2(1H)-(thio)ones (Biginelli products) moderate yield. Compounds were tested for antifungal activity against pure cultures Aspergillus niger, flavus, Candida albicans Saccharomyces cerevisiae but, unfortunately, none showed any appreciable activity.
Abstract We have prepared a series of novel 2,3‐dihydro‐4‐pyridones containing boronate esters using the aza Diels–Alder reaction with Danishefsky's diene and imines derived from formylphenylboronic acids. This can be carried out in moderate to high yields Yb(OTf) 3 as Lewis acid catalyst. Two new boron compounds exhibited antifungal activity (at 100 μg disk −1 ) Amphotericin B control. © 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:56–63, 2009; Published online InterScience (...
Ethanol solutions of the cobalt(ii) halides react with an excess 2-(ortho-anilinyl)-4,4-dimethyl-2-oxazoline (1: i.e. 2-(2′-anilinyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole) to give isolable κ2-N,N′-bonded species 1 in good excellent yields. The complexes CoX2(1-κ2-N,N′)·(H2O) n have been isolated for X = Cl (2: 1/2), Br and I (3 4, respectively; 0); solid-state structures (X-ray) are accordance those suggested by UV-visible spectroscopy conductivity measurements (i.e. non-ionic a...
Previously identified classes of antifungal disulfides are modified by extending alkyl substituents. Although, the principal focus is on f -sulfone disulfides, one nitrophenyl disulfide and a pair -ester were also prepared examined. Optimum fungitoxicity associated with structures which have seven to ten carbon atoms in form unbranched chains and/or phenyl rings.
Recently developed synthetic methodology has been exploited for the preparation of an assortment α,α´-disubstituted disulfides including all three linkage isomeric types α,α´-diester dimethyl disulfides. Two diesters are very powerful antifungal agents against Aspergillus niger and flavus. An α-ester α´-sulfone disulfide is most fungitoxin by this ongoing research effort.